Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females [0.03%]
植物类膳食补充剂对心血管、认知和代谢功能的影响：男性与女性的差异
Scott Carlson,Ning Peng,Jeevan K Prasain et al.
Scott Carlson et al.
Background: The onset of menopause marks a pivotal time in which the incidence of hypertension and of cardiovascular disease (CVD) begins to increase dramatically in women. Before menopause, the incidences of these diseas...
Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertension [0.03%]
性激素在年轻的和年老的雌mRen2.Lewis大鼠中的不同效应：一个雌激素和盐敏感型高血压模型
Mark C Chappell,Brian M Westwood,Liliya M Yamaleyeva
Mark C Chappell
Background: Male-female differences in the expression of hypertension and in end-organ damage are evident in both experimental models and human subjects, with males exhibiting a more rapid onset of cardiovascular disease ...
Xiaoying Qiao,Kristi R McConnell,Raouf A Khalil
Xiaoying Qiao
Background: Sex hormones play a significant role in human physiology. Estrogen may have protective effects in the cardiovascular system, as evidenced by the decreased incidence of cardiovascular disease (CVD) in premenopa...
Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system [0.03%]
遗传和药理学策略确定雌激素受体α和雌激素受体β在心血管系统中的功能
Paula Anahi Arias-Loza,Virginija Jazbutyte,Theo Pelzer
Paula Anahi Arias-Loza
Background: The biological functions of estrogens extend beyond the female and male reproductive tract, affecting the cardiovascular and renal systems. Traditional views on the role of postmenopausal hormone therapy (HT) ...
Sharon Silbiger,Joel Neugarten
Sharon Silbiger
Background: Gender affects the incidence, prevalence, and progression of renal disease. In animal models of the disease, female sex appears to modify the course of progression. Hormonal manipulation by male or female cast...
Need for research on estrogen receptor function: importance for postmenopausal hormone therapy and atherosclerosis [0.03%]
雌激素受体功能研究的必要性及其在绝经后激素替代治疗和动脉粥样硬化防治中的意义研究
Matthias R Meyer,Elvira Haas,Matthias Barton
Matthias R Meyer
Background: Cardiovascular disease is the leading cause of morbidity and mortality in men and women worldwide. Although rare in premenopausal women, its incidence rises sharply after menopause, indicating atheroprotective...
Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin? [0.03%]
妊娠期胎盘缺血所致高血压的发病机制：内皮素起中心作用？
Babbette D LaMarca,Barbara T Alexander,Jeffery S Gilbert et al.
Babbette D LaMarca et al.
Background: Preeclampsia is new-onset hypertension with proteinuria during pregnancy. The initiating event in preeclampsia has been postulated to involve reduced placental perfusion, which leads to widespread dysfunction ...
Daniela Grigore,Norma B Ojeda,Barbara T Alexander
Daniela Grigore
Background: Numerous clinical and experimental studies support the hypothesis that the intrauterine environment is an important determinant of cardiovascular disease and hypertension. ...
Raymond Quigley
Raymond Quigley
Background: Disrupting the enzyme cytochrome P4a14 in mice leads to hypertension, which is more severe in male than in female mice and appears to be due to androgen excess. Androgens are known to increase expression of an...
Pascale H Lane
Pascale H Lane
Background: Sex differences in human and animal models of kidney disease suggest that estrogen receptor (ER)-mediated events may modulate these processes. Genetically altered mice lacking one or both ERs provide a powerfu...