Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model [0.03%]
一种生物活性小分子通过激活PI3K/AKT信号通路促进皮肤烧伤伤口愈合和毛囊再生的临床前评估研究
Tinghui Wu,Yan Man Zhang,Sasirekha Krishnan et al.
Tinghui Wu et al.
Rational: A bioactive small molecule of precision medicine involves targeted therapies. Shikonin, a herbal extract, is an active small molecule that is traditionally used in wound healing for its anti-tumor and anti-inflammatory properties....
Research on Orientation of Basic Fibroblast Growth Factor with Magnetic Nanoparticles (MNPs) on Regeneration and Recovery of Rats' Dampened Skeletal Muscle and Expressed Level of Matrix Metalloproteinase [0.03%]
磁性纳米颗粒（MNP）导向的基础成纤维细胞生长因子对大鼠萎缩骨骼肌再生修复作用及基质金属蛋白酶表达水平影响的研究
Bicheng Jin,Lei Zhang,Xiaowei Wang et al.
Bicheng Jin et al.
The basic fibroblast growth factor (bFGF) has a special role in improving proliferation and differentiation of fiber cells in growth of muscle. The function of bFGF with magnetic nanoparticles (MNPs) on regeneration and recovery of rats' da...
Small Molecule Modifications Significantly Increase the Transfection Efficiency of Low-Molecular Polymer [0.03%]
小分子修饰显著提高低聚小分子的转染效率
Pengfei Cui,Jianhe Ma,Huihui Zhang et al.
Pengfei Cui et al.
Gene vectors with high biocompatibility and transfection efficiency are critical for successful gene therapy. PEI 25K (Polyethyleneimine 25K) is a common polymeric gene vector that has been employed as a positive control material in gene tr...
Icariin Attenuation of Diabetic Kidney Disease Through Inhibition of Endoplasmic Reticulum Stress via G Protein-Coupled Estrogen Receptors [0.03%]
淫羊藿黄酮通过G蛋白偶联雌激素受体抑制内质网应激从而缓解糖尿病肾病
Baolin Su,Dejin Cheng,Gangyi Chen et al.
Baolin Su et al.
Diabetic kidney disease (DKD) is the most common complication of diabetes mellitus and has become the primary cause of End-Stage Renal Disease (ESRD) globally. Icariin (ICA), an effective component extracted from Epimedium, has antiosteopor...
Visualized Genotyping from "Sample to Results" Within 25 Minutes by Coupling Recombinase Polymerase Amplification (RPA) With Allele-Specific Invasive Reaction Assisted Gold Nanoparticle Probes Assembling [0.03%]
通过重组酶聚合酶放大与特异性入侵反应金纳米粒子探针结合实现“样本到结果”的基因型可视化检测（25分钟内完成）
Likun Zhang,Xueping Ma,Danni Liu et al.
Likun Zhang et al.
A simple and rapid genotyping method with less-instrumentation is essential for realizing point-of-care detection of personalized medicine-related gene biomarkers. Herein, we developed a rapid and visualized genotyping method by coupling re...
Gold-Nanoparticle-Conjugated Citrate Inhibits Tumor Necrosis Factor- α Expression via Suppression of Nuclear Factor Kappa B (NF- κ B) Activation in Breast Cancer Cells [0.03%]
柠檬酸修饰的金 nanoparticles通过抑制核因子κB活化来抑制乳腺癌细胞中肿瘤坏死因子α表达
Abdullah S M Aljohani,Ahmed A H Abdellatif,Zafar Rasheed et al.
Abdullah S M Aljohani et al.
One of the leading causes of death worldwide is cancer. Excessive production of tumor necrosis factor (TNF)-α is known to activate nuclear transcription factor (NF)-κB, which plays a lethal role in the onset of multiple disorders includin...
Research on Mechanism of miR-106a Nanoparticles Carrying Dexmedetomidine in Regulating Recovery and Metabolism of Nerve Cells in Hypoxia-Reoxygenation Injury [0.03%]
miR-106a载氯氨酮纳米粒调节缺氧复氧损伤神经元 recovery和代谢的机制研究
Shu Yang,Lei Guo,Duozi Wang et al.
Shu Yang et al.
We studied the mechanism of miR-106a nanoparticles carrying dexmedetomidine (DEX) in regulating the recovery and metabolism of nerve cells in hypoxia-reoxygenation injury. Hippocampus neuron model in hypoxia-reoxygenation injury was prepare...
Randomized Controlled Trial
Journal of biomedical nanotechnology. 2022 Feb 1;18(2):343-351. DOI:10.1166/jbn.2022.3244 2022
Liposome Loaded Ion/Temperature Dual Responsive Gellan Gum Hydrogel as Potential Nasal-To-Brain Delivery System [0.03%]
负载脂质体的离子/温度双响应角叉菜胶凝胶作为鼻递送系统用于治疗阿尔茨海默病的研究
Shuwen Zhou,Xinmeng Zheng,Jun Chen et al.
Shuwen Zhou et al.
Intranasal administration, which can bypass the blood-brain barrier (BBB), is widely recognized as a promising strategy for high-efficiency drug delivery to the brain. Herein, for the purpose of effectively delivering drugs to the brain via...
Expression of Matrix Metalloprotein 13 in Injury Model of Articular Chondrocyte in Rabbits and Analysis of Nano-Drug-Loading System [0.03%]
兔关节软骨细胞损伤模型中基质金属蛋白酶13的表达及纳米载药系统的分析研究
Yicun Yao,Dongping Ye,Peifen Lin et al.
Yicun Yao et al.
This study aimed to analyze the application of a responsive nano-drug-loading system in injury model of articular chondrocyte in rabbits, as well as its effect on expression of matrix metalloprotein 13 (MMP13). The nanoprecipitation method ...
Evaluating Membrane Electrical Properties of SMMC7721 Cells with TiO₂ NPs Applications to Cytotoxicity by Dielectric Spectroscopy [0.03%]
利用介电谱技术评价TiO₂纳米粒子对SMMC-7721细胞膜电性质的影响及细胞毒性研究
Jia Xu,Lichao Cen,Qing Ma
Jia Xu
Titanium dioxide nanoparticles (TiO₂ NPs) represent one of the most frequently applied nanomaterials in numerous areas of daily life. Recent studies show that TiO₂ exposure increases the occupational risk of liver injury and inflammation,...