Targeting Pulmonary Artery Infusion of Nuclear-Targeted Plasmid-Based Short Hairpin RNA (ShRNA) to Hypoxia Inducible Factor-1 α 3 (pshHIF-1 α 3) Nano-Microspheres for Treatment of Implanted Lung Cancer in Rats [0.03%]
肺动脉灌注载核定位短发卡rna（shRNA）质粒纳米微球（pshHIF-1 α 3）治疗移植性肺癌研究
Rui Zhao,Shan Gao,Haiqi He et al.
Rui Zhao et al.
The pshHIF-1α3 stealth nanospheres have been studied if they have the function of arterial targeted drug delivery to provide a new arterial targeted drug delivery method for interventional therapy of lung cancer. The study is also aimed at...
Recent Advances of Human Leukocyte Antigen (HLA) Typing Technology Based on High-Throughput Sequencing [0.03%]
基于高通量测序的人类白细胞抗原(HLA)分型技术新进展
Jin Yang,Hongna Liu,Wenjing Pan et al.
Jin Yang et al.
The major histocompatibility complex (MHC) in humans is a genetic region consisting of cell surface proteins located on the short arm of chromosome 6. This is also known as the human leukocyte antigen (HLA) region. The HLA region consists o...
Enhanced Antibacterial and Osteogenic Properties of Graphene Oxide Loaded with Berberine on Biomedical Titanium [0.03%]
载小檗碱的氧化石墨烯改性生物医用钛的抗菌与成骨性能
Xia-Ying Han,Tong Meng,Jian-Xin Ye et al.
Xia-Ying Han et al.
Internal implants are widely used in most orthopedic surgeries, of which titanium and its alloys are most widely used owing to the excellent corrosiveness resistance, low elastic modulus and good biocompatibility. However, implant failure s...
Coating Silica Layer on Fe₃O₄ Magnetic Nanoparticles and Application in Extracting High Quality Nucleic Acids from Blood Sample [0.03%]
硅包被四氧化三铁磁性纳米颗粒及其在血液样本高质量核酸提取中的应用研究
Zeeshan Ali,Jun Zou,Xiaolong Liu et al.
Zeeshan Ali et al.
The given research revealed that the size of Fe₃O₄ magnetic nanoparticles (MNPs) could be controlled by varying the pre-mixing conditions in the solvothermal method. Scanning electron microscopy (SEM) showed that the size of the MNPs grad...
Dual pH and Temperature-Sensitive Nanogels Loaded with Eugenol for Regulating Central Nervous System [0.03%]
载有丁香酚的双重pH和温度敏感性纳稠胶用于调节中枢神经系统
Yan Li,Jing-Wen Wang,Qiu-Shi Dong et al.
Yan Li et al.
Fragrances have many biological activities such as anti-anxiety, anti-depression, and improving cognitive memory. However, most fragrances are so volatile that the useful lifespan of the fragrances is very short and excessive fragrance conc...
X-Linked Inhibitor of Apoptosis Protein (XIAP)-Loaded Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-233 to Improve Radio Sensitization of Cervical Cancer Cells and Promote Apoptosis [0.03%]
负载miR-233的磁性介孔二氧化硅纳米粒包封X染色体连锁凋亡抑制蛋白（XIAP）改善宫颈癌细胞放射增敏及促凋亡作用
Wen Li,Fang Li,Yang Zhang et al.
Wen Li et al.
This study investigated the impact of magnetic mesoporous silica nanoparticles (MMSN)-encapsulated X-linked inhibitor of apoptosis protein (XIAP) and miR-233 on tumor microenvironment in cervical cancer, to provide targeted treatment and st...
The Treatment of Human Colon Xenografts Tumor in Mice with Platinum Nanosphere-5-Fluorouracil-Bovine Albumin [0.03%]
铂纳米球-氟尿嘧啶-牛血清白蛋白对人结直肠癌异种移植瘤的治疗作用研究
Hui Li,Yi Sun,Li-Li Gao et al.
Hui Li et al.
Because 5-fluorouracil (FLU) has side effects in cancer treatment, the use of FLU in therapeutic activities is limited. To overcome this challenge, the use of nano-platforms for its targeting is f great interest in biomedical fields. For th...
Nanocarrier-Based Tumor-Targeting Drug Delivery Systems for Hepatocellular Carcinoma Treatments: Enhanced Therapeutic Efficacy and Reduced Drug Toxicity [0.03%]
基于纳米载体的肝细胞癌肿瘤靶向药物递送系统：增强治疗功效和降低药物毒性
Tian Tian,Jian Ruan,Jia Zhang et al.
Tian Tian et al.
Hepatocellular carcinoma (HCC), due to the lack of efficient diagnostic methods and short of available treatments, becomes the third main cause of cancer deaths. Novel treatments for HCCs are thus in great need. The fast-growing area of dru...
Nanoparticles Loaded with GSK1059615 Combined with Sorafenib Inhibited Programmed Cell Death 1 Ligand 1 Expression by Negatively Regulating the PI3K/Akt/NF- κ B Pathway, Thereby Reversing the Drug Resistance of Hepatocellular Carcinoma to Sorafenib [0.03%]
载有GSK1059615的纳米颗粒与索拉非尼联用通过抑制PI3K/Akt/NF- κ B信号通路下调PD-L1表达逆转肝癌细胞对索拉非尼耐药性
Shuping Zhou,Yongfang Ma,Ruyue Xu et al.
Shuping Zhou et al.
Activation of the cellular signaling pathways can induce sorafenib-resistant hepatocellular carcinoma (HCCR). In this work, the PI3K/mTOR inhibitor GSK1059615 inhibited the proliferation and invasion of HCCR cells. PLGA-PEG-mal diblock copo...
Circulating Abnormal Extracellular Vesicles: Their Mechanism for Crossing Blood-Brain Barrier, Effects on Central Nervous System and Detection Methods [0.03%]
循环异常外泌体及其穿越血脑屏障机制、对中枢神经系统影响及检测方法研究进展
Boyue Fan,Jiaqi Gu,Jie Wu et al.
Boyue Fan et al.
Central nervous system (CNS) diseases are difficult to treat and harmful. Many CNS diseases are secondary to peripheral diseases, such as tumor brain metastases (BMS), viral infections and inflammation of the brain, and their pathogenic fac...