Advances in engineered exosome-loaded hydrogels for bone and cartilage regeneration [0.03%]
工程化外体负载水凝胶在骨和软骨再生中的研究进展
Meenaloshini Gopalakrishnan,Nandhini Jayaprakash
Meenaloshini Gopalakrishnan
Exosome-loaded hydrogels have emerged as a promising strategy for bone and cartilage regeneration by combining the bioactive signaling of exosomes with the structural support of hydrogels. Exosomes, nanosized extracellular vesicles, mediate...
Preparation of Pt-TiS2 nanocomposite based amperometric glucose biosensor [0.03%]
基于Pt-TiS2纳米复合材料的安培型葡萄糖生物传感器的制备
Ulviye Kilimci,Baha Öndeş,Çağdaş Sunna et al.
Ulviye Kilimci et al.
In this study, an amperometric biosensor was developed using a glucose oxidase-functionalized Pt-TiS₂ nanocomposite for the sensitive and accurate detection of glucose. Pt nanoparticles (5-10 nm) were uniformly distributed on layered TiS₂...
Bioinspired hydrogels for infectious and diabetic wound healing: Therapeutic strategies and innovations [0.03%]
仿生水凝胶在感染性和糖尿病伤口愈合中的治疗策略和创新疗法
Sadeed Ahmad,Mishal Fatima,Muhammad Zulqarnain et al.
Sadeed Ahmad et al.
Several challenges in wound healing are addressed using hydrogels. Hydrogel supports new tissue formation and facilitates cell migration as it provides a moist environment at the wound site. Such moist conditions are ideal for faster recove...
Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in oncological therapeutics: Mechanisms of targeted delivery and encapsulation strategies for chemotherapeutics, gene modulators, and phytochemicals [0.03%]
聚DL-乳酸-co-乙醇酸(PLGA)纳米颗粒在肿瘤治疗中的靶向递送机制及化疗药物、基因调节剂和植物化学物质的包封策略
Mythileeswari Lakshmikanthan,Sakthivel Muthu,Kathiravan Krishnan et al.
Mythileeswari Lakshmikanthan et al.
Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) have emerged as a versatile and biodegradable platform for targeted cancer therapy, offering enhanced drug solubility, sustained release profiles, and improved pharmacokinetics. Their ...
Berberine chloride-loaded polymeric lipid hybrid nanoparticles ameliorate cognitive impairment by reducing phosphorylation of tau at threonine 231 [0.03%]
氯化小分子巴布期烷-多聚物脂质杂合纳米粒通过降低tau蛋白苏氨酸231位点的磷酸化改善认知障碍
Farhan Mazahir,Vikrant Rahi,Amit Kumar et al.
Farhan Mazahir et al.
Berberine chloride-loaded polymeric lipid hybrid nanoparticles (BBC-PLPNPs) were developed and surface-functionalized with transferrin (TBBC-PLPNPs) for targeted brain delivery in Alzheimer's disease therapy. The optimized nanoparticles sho...
Dual-targeting zein janus nanoparticles reprogram tumor-associated macrophages for enhanced glioblastoma therapy [0.03%]
双靶向的zein Janus纳米颗粒重新编程肿瘤相关巨噬细胞以增强胶质母细胞瘤治疗效果
Kun Ma,Zicheng Liu,Senchao Chai et al.
Kun Ma et al.
Glioblastoma (GBM) is one of the most malignant and lethal primary brain tumors, and the blood-brain barrier (BBB) poses a significant challenge to its treatment. In this study, disulfiram-loaded Zein Janus nanoparticles (Lf/M2pep@ZEN-DSF) ...
A clinically relevant retrograde intraductal injection (RIDI) for lipid nanoparticles-mediated base editing in the pancreas [0.03%]
一种临床相关的逆向导管内注射(RIDI)，用于胰腺脂质纳米颗粒介导的碱基编辑
Deepak Sahel,Amita Tiyaboonchai,Leslie Wakefield et al.
Deepak Sahel et al.
Gene therapy offers potential curative strategies for many pancreatic diseases, including diabetes and inherited pancreatitis. However, their clinical translation has been hindered by the lack of an effective delivery platform. Lipid nanopa...
Corrigendum to "DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles" [Nanomed Nanotechnol Biol Med 10.1016/j.nano.2016.11.019 [pubmed: 27979747 issn: 1549-9634]] [0.03%]
关于“用于宫颈癌的DNA疫苗；一种新型RALA介导基因传递技术平台（通过聚合物微针）”的勘误([Nanomed Nanotechnol Biol Med 10.1016/j.nano.2016.11.019 [pubmed: 27979747 issn: 1549-9634]])
A A Ali,C M McCrudden,J McCaffrey et al.
A A Ali et al.
Melatonin-loaded MSCs-derived exosomes as therapeutic carriers to alleviate levodopa-induced dyskinesia in Parkinson's disease [0.03%]
褪黑素负载的间充质干细胞来源的外泌体作为多巴诱发不自主运动的治疗载体
Lin Liu
Lin Liu
Parkinson's disease (PD) causes dopaminergic neuron damage in substantia nigra, with levodopa-induced dyskinesia (LID) as a side effect of long-term treatment with levodopa. Exosomes (Exo) from mesenchymal stem cells (MSC) are getting atten...
From carrier to therapeutic agent: The multifunctional roles of ZIFs in synergistic cancer therapy [0.03%]
从载体到治疗剂：ZIF在协同癌症治疗中的多功能作用
Yalong Pan,Guanzhi Huang,Lijun Han et al.
Yalong Pan et al.
The high incidence and complex pathophysiology of cancer limit the efficacy of single therapeutic modalities, creating an urgent demand for integrated treatment strategies with multifunctional capacities. Zeolitic imidazolate frameworks (ZI...