Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures [0.03%]
基于两性离子肽和β-肽的纳米丝状结构的组装及作为抗原递送载体的研究比较
Laetitia Mwadi Tshibwabwa,Phuong Trang Nguyen,Steve Bourgault
Laetitia Mwadi Tshibwabwa
Synthetic peptide vaccines have a high safety profile, although their low immunogenicity requires the use of potent adjuvants and delivery systems. Self-assembling β-peptides and amphiphilic peptides have been identified as versatile build...
Development and evaluation of choline tagged mesoporous silica nanoparticles for targeted delivery and imaging in prostate cancer [0.03%]
一种用于前列腺癌靶向递送和成像的胆碱标记介孔二氧化硅纳米颗粒的开发与评估
Nikhil Kumar,Pritha Bose,Subodh Kumar et al.
Nikhil Kumar et al.
This study presents MSNCHDT@DTX, mesoporous silica nanoparticles (MSN) functionalized with choline and diethylenetriaminepentaacetic acid (DTPA), designed as a theranostic agent integrating targeting, imaging, and therapy. Docetaxel (DTX) u...
Enhanced paclitaxel oral delivery by astragalus polysaccharide-based nanoplatform for triple-negative breast cancer treatment [0.03%]
黄芪多糖基纳米递药平台增强口服紫杉醇治疗三阴性乳腺癌功效
Wenlong Nie,Zhijun Bi,Yi Shen et al.
Wenlong Nie et al.
Oral delivery of paclitaxel (PTX) is hindered by poor aqueous solubility, low bioavailability, and gastrointestinal toxicity, limiting its clinical breast cancer treatment. Here, we developed a novel oral nanoplatform (APS-PTX NPs) using As...
Midas touch at the nano-bio interface: Size-dependent attenuation of parathyroid hormone signaling by gold nanoparticles [0.03%]
神奇的触指效应在纳米-生物界面：金纳米颗粒通过尺寸依赖性削弱甲状旁腺激素信号转导
Xingchen Zhou,Jin Yan,Wangxiao He et al.
Xingchen Zhou et al.
Peptide hormone signaling is increasingly recognized as a target for nanomaterial-mediated modulation, yet how nanoparticle size governs nano-peptide interfacial interactions remain poorly understood. Here, gold nanoparticles (AuNPs) of con...
Ultrasensitive detection of NSE lung cancer biomarker using label-free electrochemical biosensor based on carbon nanotube and graphene quantum dots nanocomposite [0.03%]
基于碳纳米管和石墨烯量子点纳米复合材料的无标记电化学生物传感器检测NSE肺癌生物标志物的新方法研究
Neha Maurya,Himshikha Malviya,Saurabh Srivastava et al.
Neha Maurya et al.
We introduce a label-free electrochemical biosensor designed for the detection of Neuron-Specific Enolase (NSE), a critical biomarker associated with small cell lung cancer. Elevated NSE levels indicate tumor presence, enabling early diagno...
Chemically mediated modification of bacteriophages: Strategies, functionalities and applications in precision medicine [0.03%]
化学介导的噬菌体修饰：策略、功能及精准医学中的应用
Mishal Hameed,Yueshan Hu,Afrasyab Khan et al.
Mishal Hameed et al.
Bacteriophages are tiny microorganisms with remarkable specificity and versatility, contributes as promising tools in modern biomedicine due to their innate affinity for bacterial hosts. However, in order to effectively utilize their potent...
Multifunctional polydopamine modified nano-hydroxyapatite doped sodium alginate/gelatin dual network hydrogel for bone tissue engineering scaffolds [0.03%]
用于骨组织工程支架的多功能聚多巴胺修饰纳米羟基磷灰石掺杂的 sodium alginate/gelatin 双网络水凝胶
Weijie Dong,Tingshu Su,Xinyun Zhang
Weijie Dong
Hydrogels have the structure and composition of extracellular matrix, but single component hydrogels are often difficult to meet the needs of multi-function. Therefore, in view of the common requirements of anti-infection and promoting bone...
Asy-RPA/PCR combined with One-crRNA-CRISPR/Cas12a for simultaneous detection of multiple Clarithromycin resistance mutations in Helicobacter pylori [0.03%]
基于Asy-RPA/PCR和单导向crRNA的CRISPR/Cas12a技术同时检测幽门螺杆菌克拉霉素耐药多位点变异
Yanghe Liu,Shiyue Chen,Chunlei Zhang et al.
Yanghe Liu et al.
Methods: Genetic testing for Clarithromycin resistance-associated single-nucleotide variations (SNVs) in H. pylori could be applied for formulating individual eradication plan. In this study, we integrated asymmetric reco...
Enhanced tumor immunohistochemical detection using a protein A-fused Pyrococcus furiosus ferritin carrier with drastically reduced antibody amount [0.03%]
一种基于蛋白A融合的Pyrococcus furiosus铁蛋白抗体放大载体的低抗体免疫组化检测方法
Fengjiao Fang,Xiang Xu,Changqian Cao et al.
Fengjiao Fang et al.
Immunohistochemistry (IHC) is a cornerstone technique in tumor pathology. However, the detection of low-abundance antigens often requires high antibody input, increasing cost and limiting analytical efficiency. Here, we developed a novel fe...
Osimertinib delivery using 660 nm-activated polymeric nano-photosensitizer carriers for combined photodynamic and EGFR-targeted therapy of non-small cell lung cancer [0.03%]
用于非小细胞肺癌光动力和EGFR靶向治疗的聚合物纳米光敏载体介导奥希替尼输送及660nm激活研究
Fanjun Zeng,Yucheng Huang,Danfeng Peng et al.
Fanjun Zeng et al.
Osimertinib (Osi), an EGFR tyrosine kinase inhibitor (TKI), significantly prolongs patients' survival with EGFR-mutated non-small cell lung cancer (NSCLC). However, extended use often leads to acquired resistance, limiting the effectiveness...