MitoPG: An engineered biocompatible nanocarrier for drug delivery to neuronal mitochondria [0.03%]
MitoPG：一种工程化的生物相容性纳米载体，用于向神经元线粒体递送药物
Nishad Keethedeth,Goutam Chandra,B Prakash Kumar et al.
Nishad Keethedeth et al.
Mitochondrial dysfunction is a key contributor to the pathogenesis of major neurodegenerative diseases such as Parkinson's disease. Targeted drug delivery to neuronal mitochondria is often limited by the inherent toxicity and inefficiency o...
Nanotechnology mediated local interventions with systemic immunotherapy for hepatocellular carcinoma: Intelligent multimodal therapy [0.03%]
纳米技术介导的局部干预与系统性免疫治疗在肝细胞癌中的应用：智能多模态治疗
Qinghe Meng,Yang Yang,Han Wu
Qinghe Meng
The therapeutic response of unresectable hepatocellular carcinoma (HCC) is constrained by the disconnect between effective local tumor management and systemic immune activation. Traditional locoregional interventions often induce a microenv...
Nanotechnology-based reformulation of AUY922 mitigates retinal toxicity and retains potent anti-tumor activity [0.03%]
纳米技术使AUY922复方剂能够缓解视网膜毒性并保持强大的抗肿瘤活性
Chi-Che Hsieh,Nai-Jung Chiang,Sin-Jie Wang et al.
Chi-Che Hsieh et al.
AUY922, a heat-shock protein 90 inhibitor, shows broad antitumor activity but is limited by dose-limiting ocular toxicity. In this study, we engineered FLIM02, a PLGA/DSPE-PEG2000 (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(eth...
Aggregation effects for thermoplasmonics and MRI with hybrid nanoparticles [0.03%]
具有热等离子体和MRI效应的杂化纳米颗粒的聚集效应
C Rousseau,Q L Vuong,Y Gossuin et al.
C Rousseau et al.
This study evaluates a combined approach for magnetic resonance imaging (MRI) and photothermal therapy using hybrid gold-magnetite nanoshell clusters. The clusters convert laser light into heat and change the transverse relaxation rate (R2)...
Genetic versus chemical labeling: A quantitative comparison of tracking strategies for extracellular vesicles [0.03%]
基因与化学标记：外泌体追踪策略的定量比较研究
Jikuan Jiang,Moxuan Yang,Shengya Xu et al.
Jikuan Jiang et al.
Background: Extracellular vesicles (EVs) play critical roles in intercellular communication and represent promising drug delivery vectors. A major challenge in the field is the lack of labeling strategies that enable quan...
Chlorogenic acid-ZnO nanocomposite derived from Hydrocotyle javanica Thunb. activates ferroptosis-regulated cell death axis in breast cancer cells [0.03%]
用Hydrocotyle javanica Thunb.衍生的绿原酸-ZnO纳米复合材料激活乳腺癌细胞中的铁死亡调节性细胞死亡轴
Anjini Bellai,Sulagna Dutta,Hui Tag et al.
Anjini Bellai et al.
Breast cancer remains one of the leading causes of cancer-related mortality among the women worldwide. The metal oxide nanoparticle-based formulations offer improved drug efficacy which makes them promising candidates for cancer therapy. Th...
From angiomiRs to nanomedicine: Self-assembling lipid hybrid nanocarriers for microRNA delivery in lung cancer [0.03%]
从angiomiRs到纳米医学：肺癌microRNA递送的自组装脂质杂化纳米载体
Romit Dutta,Athira Jayasree Kumar,Sivaramakrishnan Venkatabalasubramanian
Romit Dutta
Lung cancer persists as a critical global health challenge and drives innovation in therapeutic strategies to combat it. MicroRNAs (miRNAs) have emerged as promising therapeutic agents because of their pivotal role in gene regulation, with ...
Studies on the anti-tumor effects of curcumin synergizing with doxorubicin in inducing immunogenic cell death [0.03%]
姜黄素协同阿霉素诱导肿瘤免疫原性死亡的抗肿瘤作用研究
Yanqing Wu,Jianguo Gao,Yingzhi Lu et al.
Yanqing Wu et al.
Chemotherapy-induced immunogenic cell death (ICD) remodels the immunosuppressive tumor microenvironment and enhances chemotherapeutic efficacy. In this study, a nanoparticle delivery system, designated as CMCS-D + C/NPs, is constructed usin...
Quantum dots at the oncology interface: Transforming breast cancer diagnosis, imaging, and treatment [0.03%]
量子点在肿瘤界面的应用：转化乳腺癌的诊断、影像和治疗
Hiti Narula,Raj Kamal,Sonia Dhiman et al.
Hiti Narula et al.
Breast cancer is one of the major causes of cancer-related illnesses and deaths globally, which calls for the use of advanced technologies in early diagnosis, precise imaging, and effective therapy. Quantum dots (QDs) have become extremely ...
Magnetic nanoparticle carrying verbascoside suppresses oral squamous cell carcinoma progression by targeting ICAM1 via IL-6/STAT3 axis [0.03%]
载有verbascoside的磁性纳米颗粒通过IL-6/STAT3轴靶向ICAM1抑制口腔鳞状细胞癌的发展
Mifang Yang,Jingjing Wu,Yuan Jing et al.
Mifang Yang et al.
Oral squamous cell carcinoma (OSCC), the most common oral malignancy, requires innovative therapeutic strategies. We developed a magnetic nanoparticle carrying verbascoside (VB-Fe3O4) to enhance the bioavailability and antitumor efficacy of...