Spatiotemporally controlled depletion of efflux-dominant cells enhances intratumoral delivery of nanomedicines [0.03%]
时空可控地耗尽以排泄为主的细胞可增强纳米药物在肿瘤内的递送
Chengqiong Mao,Shuyu Zhang,Xin Ming
Chengqiong Mao
Intratumoral delivery remains a major limitation for nanomedicines in solid tumors, particularly in drug-resistant tumors containing efflux-dominant cellular subpopulations. Using P-glycoprotein (Pgp)-associated resistance as a clinically r...
CRISPR/Cas12a and nanocomposite-based electrochemical/ colorimetric parallel dual-channel aptasensor for highly sensitive LDL detection [0.03%]
一种基于CRISPR/Cas12a和纳米复合材料的电化学生物传感器及比色生物传感器平行双通道双重平台用于高灵敏度检测低密度脂蛋白
Zhide Zhou,Shuaikang Dong,Shengnan Li et al.
Zhide Zhou et al.
Atherosclerotic cardiovascular disease (ASCVD) remains a leading global health threat, necessitating precise monitoring of low-density lipoprotein (LDL) as a key risk biomarker for assessing ASCVD risk. Herein, an electrochemical/colorimetr...
One-step lipid-polymeric hybrid nanoparticles as intracanal drug delivery system: Synthesis, characterization, antimicrobial activity, and dentinal penetration [0.03%]
一步法脂质-聚合物杂化纳米颗粒根管内药物递送系统：合成、表征、抗菌活性及牙本质渗透性研究
Ahmad AlMukhallalati,Amal Yousfan,Diego Hidalgo-Martínez et al.
Ahmad AlMukhallalati et al.
Introduction: This study developed two lipid-polymeric hybrid nanoparticle thermosensitive gels, hypothesizing enhanced physicochemical properties, antimicrobial efficacy, and dentinal penetration compared to free drugs. ...
Nano formulated daidzein and genistein as a multi-targeted therapeutic strategy for letrozole-induced PCOS in rats [0.03%]
纳米包裹的大豆异黄酮治疗来曲唑致多囊卵巢综合征大鼠模型的多靶标策略研究
Neelam L Dashputre,Umesh D Laddha,Nayana K Patil et al.
Neelam L Dashputre et al.
Background: The common endocrine disorder characterised by metabolic abnormalities, hyperandrogenism, and ovulatory dysfunction is polycystic ovary syndrome (PCOS). Natural phytoestrogens like Daidzein and Genistein show ...
Designing imidazole capped laminin inspired peptide hydrogels in the presence of biologically relevant metal salts to fabricate advanced biofunctional scaffold for controlling cellular behaviour [0.03%]
在生物相关金属盐存在下设计组胺封闭的层粘连蛋白启发肽水凝胶，以制造先进的生物功能性支架来控制细胞行为
Rakesh Kumar,Pooja Sharma,Sweta Mohanty et al.
Rakesh Kumar et al.
Self-assembling peptides inspired from extracellular matrix (ECM) proteins provide a versatile platform for tissue engineering due to their biocompatible and biodegradable nature. Short oligopeptides can self-assemble into supramolecular hy...
Gold nanoparticles for sentinel lymph node mapping: Shape-engineered platforms across multimodal imaging [0.03%]
用于前哨淋巴结定位的金纳米颗粒：多模态成像下的形态工程平台
Sang Bong Lee
Sang Bong Lee
Sentinel lymph node (SLN) mapping is essential for cancer staging and image-guided surgical management, but conventional blue dyes, radiocolloids, and fluorescence tracers remain limited by spatial resolution, penetration depth, and single-...
Dual inhibition of glycolysis and epigenetics via a nanodelivery system for colorectal cancer treatment [0.03%]
基于纳米载体的抑制结直肠癌糖酵解和表观遗传学的联合治疗策略
Tingyi Li,Jingyuan Zhao,Jinnan Liu et al.
Tingyi Li et al.
Colorectal cancer (COAD) is characterized by altered metabolism and epigenetic regulation, driving tumor progression and therapeutic resistance. Here, we developed a dual-drug nanodelivery system, SD@MSN-glu, co-encapsulating shikonin (SHK,...
CHP/MMP2 dual-targeting soft mesoporous organosilica nanoparticles loaded with losartan for modulating cardiac fibrosis [0.03%]
负载洛沙坦的双靶向（糖酵解和糖异生）软介孔有机硅纳米粒子用于调节心脏纤维化
Qing Yang,Shilin Zhang,Meng Dang et al.
Qing Yang et al.
Myocardial fibrosis (MF) drives heart failure and arrhythmias, yet drug delivery to injured myocardium is hindered by the dynamic cardiac microenvironment and lack of lesion-specific targeting. Here, we developed a dual-targeted, soft mesop...
Melanin chelating zinc ions for NIR-I photoacoustic imaging-guided photothermal-pyroptosis therapy of breast cancer [0.03%]
黑色素螯合锌离子用于近红外I光声成像引导的乳腺癌光热-细胞焦亡治疗
Wenwen Cai,Chenyao Song,Jie Dong et al.
Wenwen Cai et al.
Melanin nanoparticles (MNPs), as an endogenous pigment, boasts excellent biocompatibility, multifunctional properties including photothermal conversion and radical scavenging, which exhibit broad potential for transformative biomedical appl...
Recent developments in electrochemical sensors for anticancer drugs analysis: Nanostructured innovations [0.03%]
用于抗癌药物分析的电化学传感器的最新进展：纳米结构创新
Ayub Alam,Saqib Shabbir,Sania Shabbir et al.
Ayub Alam et al.
Therapeutic drug monitoring (TDM) is very crucial for improving treatment outcomes because anti-cancer drugs have narrow therapeutic windows and their effects vary from individual to individual. Traditional analytical techniques are hampere...