Dual PLGA nanoparticles co-encapsulating P5091 and Resveratrol synergistically target the USP7-MDM2-P53 axis for glioma therapy [0.03%]
载有P5091和白藜芦醇的双重PLGA纳米粒子协同作用，靶向USP7-MDM2-P53轴用于胶质瘤治疗
Sunny Kumar,Mrinal K Ghosh
Sunny Kumar
Glioma, a Grade-IV brain tumor, often exhibits functional suppression of P53 signaling due to aberrant stabilization of MDM2 by the deubiquitinase USP7, presenting a therapeutically exploitable vulnerability that remains under-utilised beca...
Regenerative polymer-based modalities for diabetic foot ulcers: From material design to clinical translation [0.03%]
基于再生聚合物的糖尿病足溃疡治疗策略：从材料设计到临床转化
Ankur Das,Madhulika Pradhan,Ajazuddin et al.
Ankur Das et al.
Diabetic foot ulcers (DFUs) cause one amputation every 20 s globally, driven by ischemia, dysregulated growth factors, recalcitrant biofilms, and oxidative stress that render conventional therapies ineffective. This review examines smart po...
Mentha-derived green synthesized ZnO nanoparticles potentiate methotrexate induced molecular and migratory inhibition via gene expression modulation in T24 bladder cancer cells [0.03%]
薄荷醇衍生的绿色合成ZnO纳米颗粒通过调节T24膀胱癌细胞中的基因表达来增强甲氨蝶呤对分子和迁移抑制的作用
Khalid Al-Asfory,Wael I Mortada,O Y El-Khawaga et al.
Khalid Al-Asfory et al.
Bladder cancer is characterized by high recurrence rates and limited responsiveness to conventional chemotherapy, including Methotrexate (MTX). Nanotechnology-based strategies may enhance therapeutic efficacy while reducing drug resistance....
Fluvastatin-loaded chitosan-coated transfersomes for tumor-targeted nanotheranostics: Optimization, in-vitro cytotoxicity, and in-vivo radiokinetic evaluation [0.03%]
载有佛司洁纳的壳聚糖包覆转移体用于肿瘤纳米诊疗：优化、体外细胞毒性及体内放射动力学评估
Khaled M Attallah,Marwa Eid Sayyed,Shymaa Hatem
Khaled M Attallah
This study focused on developing chitosan-coated fluvastatin (FLU)-loaded transfersomes (TFs) as a nanovesicular system for tumor targeting and in-vivo tracking using technetium-99 m. The vesicles were prepared, characterized, and tested fo...
Nanostructured lipid carriers of lutein-based dissolving microneedle patch: A promising approach for the management of rheumatoid arthritis [0.03%]
基于玉米黄质的溶解型微针贴片纳米结构脂质载体：治疗类风湿性关节炎的潜在方法
Prajna Shastry,Jobin Jose,Kartik Bhairu Khot et al.
Prajna Shastry et al.
Rheumatoid arthritis is a chronic inflammatory disorder caused by immune system dysregulation. Although conventional pharmacological therapies can alleviate disease symptoms, their effectiveness is often limited by poor target specificity a...
Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization [0.03%]
基于表面电荷工程的磁性丝素纳米载体用于pH响应型氟尿苷递送及体外磁场定位
Luo Yixin,Zhang Zifan,Sun Qitai et al.
Luo Yixin et al.
Surface-charge engineering offers a simple strategy to tune magnetic nanocarriers for anticancer drug delivery. In this study, silk fibroin/Fe3O4 nanocarriers (DMSs) were prepared by assembling silk fibroin (SF) with carboxyl- or amine-func...
PEGylation-associated hemodynamic effects in a rodent model of acute hypersensitivity reaction: Complement activation-mediated mechanisms [0.03%]
聚乙二醇化介导的急性过敏反应小鼠模型中的血流动力学效应及其补体激活机制研究
Sin-Ting Ngo,Yun Cheng,Si-Yi Chen et al.
Sin-Ting Ngo et al.
Polyethylene glycol (PEG)-modified nanocomposites may induce acute hypersensitivity reactions (HSR), including complement activation and hypotension, followed by tachyphylaxis with an unknown mechanism. We tested a hypothesis that complemen...
The evolving landscape of osteoarthritis management: From conventional pharmacotherapy to gene therapy, stem cell therapy and nanotechnology-based therapeutics [0.03%]
不断变化的骨关节炎治疗格局：从传统药物治疗到基因治疗、干细胞治疗和基于纳米技术的治疗方法
Umme Jiba,Mohammad Arif Khan,Mohd Shahrukh et al.
Umme Jiba et al.
Osteoarthritis (OA) is a primary contributor to long-term disability globally due to persistent cartilage degradation and joint inflammation. Global experts have focused their efforts on symptom management rather than addressing the underly...
Dihydroartemisinin-stachyose conjugate (sDHA) improves the oral bioavailability of dihydroartemisinin and antiemphalitic malaria effects [0.03%]
二氢青蒿素-鼠李糖轭合物（sDHA）改善了二氢青蒿素口服生物利用度及抗脑疟疗效
Wen Zhao,Jun Wang,Xiao-Yue Du et al.
Wen Zhao et al.
A dihydroartemisinin (DHA)-stachyose conjugate (sDHA) was synthesized via succinate ester linkage to enhance solubility and anti-cerebral malaria efficacy. Structural characterization (FT-IR, 1H NMR) confirmed a 1:1 M ratio. sDHA exhibited ...
L220-derived peptide-bioconjugated carbon nanotubes protect hamsters against amoebic liver abscess through IL-17A-Associated immune response [0.03%]
衍生自L220的肽-生物偶联碳纳米管通过IL-17A相关的免疫反应保护仓鼠免受阿米巴性肝脓肿的影响
Alejandro Velarde-Calderón,José Jesús Guzmán-Mendoza,Erasmo Orrantia-Borunda et al.
Alejandro Velarde-Calderón et al.
The development of effective vaccines against Entamoeba histolytica remains a major challenge, particularly for preventing amoebic liver abscess (ALA). In this study, carbon nanotubes (CNTs) were evaluated as nanocarriers through bioconjuga...