Patients' and healthcare providers' views regarding dose reduction of tyrosine kinase inhibitors in chronic myeloid leukemia: a qualitative study [0.03%]
慢性粒细胞性白血病患者和医护人员对酪氨酸激酶抑制剂减量使用的看法：一项定性研究
Dina N Lokhorst,Bart J F van den Bemt,Yolba Smit et al.
Dina N Lokhorst et al.
Background: Dose reduction of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukaemia (CML) can reduce side effects and improve quality of life while maintaining treatment effectiveness and reducing c...
Minimal Residual Disease Assessment Through ctDNA Facilitates Tailored Immunotherapy in MSI-High, NTRK1-Fusion Pancreatic Adenocarcinoma [0.03%]
基于ctDNA的微小残留病灶评估在MSI-H/NTRK1融合型胰腺癌免疫治疗中应用及展望
Sarah Rohlfing,Dilyana Vladimirova,Stephanie Berger et al.
Sarah Rohlfing et al.
Pancreatic cancer remains one of the most lethal malignancies, with limited integration of precision oncology into routine clinical care. We present a unique case of a RAS wild-type, MSI-H, TMB-H pancreatic ductal adenocarcinoma harboring a...
Association between pathologic chemotherapy response score and pattern of recurrence in advanced high-grade serous ovarian cancer [0.03%]
化疗病理反应评分与晚期高级别浆液性卵巢癌复发模式之间的关系
Francesco Mezzapesa,Antonio De Leo,Camelia Alexandra Coada et al.
Francesco Mezzapesa et al.
Background: Chemotherapy Response Score (CRS) is a three-tier histopathologic system evaluating response to neoadjuvant chemotherapy (NACT) in high-grade serous ovarian cancer (HGSOC). ...
Cardiac Biomarkers in Patients With Renal Cell Carcinoma Treated With Immune Checkpoint Inhibitors [0.03%]
免疫检查点抑制剂治疗肾细胞癌患者中的心脏生物标志物变化
Yen-Chou Chen,Mandar A Aras,Brian I Rini et al.
Yen-Chou Chen et al.
Clinical evidence to assess the utility of routine cardiac biomarker surveillance during immune checkpoint inhibitor treatment is limited. We examined cardiac biomarkers at baseline and during initial treatment in the JAVELIN Renal 101 phas...
Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas [0.03%]
H2AX磷酸化水平与结直肠癌瘤内免疫微环境特征相关性研究
Enrico Berrino,Sara Erika Bellomo,Maria Costanza Aquilano et al.
Enrico Berrino et al.
Background: The phosphorylated form of the histone H2AX (γH2AX), a sensor of DNA double-strand breaks (DSB), can serve as a biomarker of DNA damage and therapy response. This study aimed to evaluate the association betwe...
Treatment Strategies for Small Cell Carcinoma of the Esophagus: Comparative Analysis of Multimodal Regimens in Two Independent Real-World Cohorts [0.03%]
食管小细胞癌的治疗策略：两组真实世界数据中多模式方案的比较分析
Xiaolei Yin,Xiaopeng Li,Lili Mi et al.
Xiaolei Yin et al.
Background: Small cell carcinoma of the esophagus (SCCE) is a rare and aggressive malignancy lacking a standardized treatment approach. Multimodal strategies such as chemotherapy plus surgery (CT + S) or chemotherapy plus...
Primary brainstem lymphoma: clinical characteristics, treatment methods, and prognostic factors of 56 patients [0.03%]
原发脑干淋巴瘤的临床特点、治疗方式及预后因素分析（56例）
Wenhui Guo,Ling Duan,Shuo Yin et al.
Wenhui Guo et al.
Background: Primary brainstem lymphoma (PBSL) is rare and generally has a poor prognosis. This study aimed to analyze the clinical, therapeutic, and prognostic factors in a single-center retrospective cohort. ...
Cancer: A looming public health crisis in Africa-a call to accelerate equitable access to medicines [0.03%]
癌症：加速非洲公平用药以应对迫在眉睫的公共卫生危机
Rose I Anorlu,Lemchukwu C Amaeshi,Kehinde S Okunade et al.
Rose I Anorlu et al.
The global incidence of cancer is on the rise, with Africa experiencing a particularly steep increase in both cancer incidence and mortality. This upward trend is driven by a combination of factors, including population growth, poverty, agi...
Homologous Recombination Deficiency and Genomic Alterations in Advanced Prostate Cancer: Insights for Precision Therapy [0.03%]
前列腺癌同源重组缺陷和基因组改变：精确治疗的见解
Chiara Mercinelli,Dean Pavlick,Neeraj Agarwal et al.
Chiara Mercinelli et al.
Background: the homologous recombination deficiency signature (HRDsig) is emerging as a novel potential predictor of PARP-inhibitor (PARPi) response. We compared genomic alterations (GA) across BRCA2-loss, BRCA2 short var...