Predictive factors for early mortality after regorafenib or trifluridine/tipiracil initiation in metastatic colorectal cancer [0.03%]
雷戈菲尼或替拉普利治疗转移性结直肠癌的早期死亡预测因素分析
Toshiki Masuishi,Shota Fukuoka,Atsuo Takashima et al.
Toshiki Masuishi et al.
Background: Regorafenib and trifluridine/tipiracil (FTD/TPI) are standard later-line treatments for patients with refractory metastatic colorectal cancer. However, these drugs show limited efficacy in some patients, and i...
Comparative real-world progression free survival of CDK4/6 inhibitors in HR+/HER2- breast cancer patients with bone metastases [0.03%]
HR阳性、HER2阴性乳腺癌骨转移患者中CDK4/6抑制剂的现实世界无进展生存比较研究
Roberta Scafetta,Marco Donato,Carla Gullotta et al.
Roberta Scafetta et al.
Background: The introduction of CDK4/6 inhibitors (CDK4/6i) has improved outcomes in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer (mBC), including in patients with bone metastases. Assessing thei...
Comparative Study
The oncologist. 2026 Apr 10;31(5):oyag146. DOI:10.1093/oncolo/oyag146 2026
Characterization and Clinical Management of Adverse Events Following Treatment with Repotrectinib: A TRIDENT-1 Analysis [0.03%]
Repotrectinib治疗后的不良事件的特征及临床管理：来自TRIDENT-1的研究分析
Alexander Drilon,Byoung Chul Cho,D Ross Camidge et al.
Alexander Drilon et al.
Background: Repotrectinib, a next-generation ROS1/TRK tyrosine kinase inhibitor, is approved for ROS1 fusion-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. Its side effects and safety managemen...
Metabolic profile and skeletal muscle as predictors of survival in testicular germ cell tumors [0.03%]
代谢谱和骨骼肌对睾丸生殖细胞瘤生存率的预测作用
Alejandra Barrón-Hernández,Juan Alberto Ríos-Rodríguez,José Antonio García-Pacheco et al.
Alejandra Barrón-Hernández et al.
Background: Testicular germ cell tumors (TGCT) are highly curable malignancies, yet the prognostic impact of host metabolic status remains underexplored, especially in non-Caucasian populations. ...
Impact of geriatric covariates on metronomic cyclophosphamide efficacy and tolerance-the CHEMETROLD study [0.03%]
老年伴随疾病对小剂量吉西他滨疗效及耐受性的影响-化疗 Metrold 研究
Clara Griffe,Christine Ravot,David Dayde et al.
Clara Griffe et al.
Background: Metronomic cyclophosphamide is sometimes considered in older or frail patients with advanced cancer when disease-related symptoms affect quality of life and standard treatments are no longer suitable. While cl...
Mucinous histology and resistance to immune checkpoint blockade in patients with microsatellite instability-high metastatic colorectal cancer [0.03%]
微卫星不稳定性高的转移性结直肠癌患者黏液型组织学与免疫检查点抑制剂耐药之间的关系
Vincenzo Nasca,Margherita Ambrosini,Julien Taieb et al.
Vincenzo Nasca et al.
Background: Mucinous phenotype has been associated with an immune-cold microenvironment in dMMR/MSI-H CRC. Here, we investigated the impact of mucinous histology on resistance to ICIs in patients with dMMR/MSI-H mCRC. ...
Phase 2 Study of Cabozantinib (XL184) with Nivolumab and Ipilimumab for the Treatment of Poorly Differentiated Neuroendocrine Carcinomas (ETCTN10315) [0.03%]
卡博替尼(XL184)联合纳武单抗和伊匹单抗治疗分化差的神经内分泌癌的II期研究(ETCTN10315)
Adel Mandl,Ruizhe Chen,Satya Das et al.
Adel Mandl et al.
Background: Poorly differentiated neuroendocrine carcinomas (NECs) are aggressive malignancies with limited treatment options. The low activity of immune checkpoint inhibitors (ICI) is in part due to an immunosuppressive ...
Immunotherapy with Guts: A review of microbial therapeutic adjuncts for immunotherapy in solid tumors [0.03%]
有影响力的肠道免疫治疗：实体瘤免疫治疗的微生物辅助疗法综述
Kelly Pum,Emil Lou,Paolo Goffredo et al.
Kelly Pum et al.
Background: Immunotherapy has transformed the management of some solid tumor types, but its impact has been limited to the subset of cancer patients who have 'hot' or immunogenic tumors. Numerous studies are based on stra...
OncoEducate: a pilot study of generative AI to enhance patient-clinician communication in genitourinary cancer care [0.03%]
OncoEducate：一项关于在泌尿生殖系统癌症护理中使用生成式人工智能增强患者与临床医生沟通的试点研究
Henry K Litt,Amelia Wodzinski,Pearl Subramanian et al.
Henry K Litt et al.
OncoEducate is a clinician-supervised generative artificial intelligence (AI) application designed to deliver standardized, regimen-level, plain-language education at the point of care. We developed a templated handout generator using a loc...
EMBARK in biochemically recurrent prostate cancer: a journey for some but not most [0.03%]
EMBARK在生化复发前列腺癌中的应用：只适用于部分患者？
Melissa L Abel,Fatima Karzai,Ravi A Madan
Melissa L Abel