The Emerging Implications of GLP-1 Receptor Agonists in Radiation Therapy [0.03%]
GLP-1受体激动剂在放射治疗中潜在作用的初步探索及其深远意义
Trenton Reinicke,Joshua T Dilworth
Trenton Reinicke
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for patients with diabetes, obesity, and cardiometabolic disease. This trend has led to a growing number of patients taking these medications while receiving ...
Phase II study of maintenance trifluridine/tipiracil (TAS-102) plus bevacizumab after induction chemotherapy in metastatic colorectal cancer [0.03%]
一项关于继发化疗后维持使用曲氟尿苷替匹嘧啶(TAS-102)联合贝伐单抗治疗转移性结直肠癌的II期研究
Katsuya Ota,Mamoru Uemura,Tsukasa Tanida et al.
Katsuya Ota et al.
Background: First-line chemotherapy with maintenance therapy is expected to be well-tolerated and improve survival in patients with metastatic colorectal cancer (mCRC). This study evaluated the efficacy and safety of trif...
Multifocality as a Marker of Aggressiveness in Medullary Thyroid Carcinoma: A Retrospective Cohort Analysis of Lymph Node Metastasis and Recurrence [0.03%]
多发病灶是甲状腺髓样癌侵袭性的标志吗？一项关于淋巴结转移和复发的回顾性队列分析研究
Yidan Lu,Ziyi Chen,Jing Yang et al.
Yidan Lu et al.
Background: The prognostic role of multifocality in medullary thyroid carcinoma (MTC) is controversial. This study evaluated multifocality's association with aggressiveness, lymph node metastasis (LNM), and survival, focu...
Real-world outcomes of encorafenib, cetuximab ± binimetinib for BRAF‑mutated metastatic colorectal cancer: The BEETS (JACCRO CC‑18) study [0.03%]
贝拉法尼布、西妥昔单抗联合或不联合比美替尼治疗BRAF突变型转移性结直肠癌的真实世界结果：BEETS（JACCRO CC-18）研究
Daisuke Kotani,Eisuke Inoue,Tadamichi Denda et al.
Daisuke Kotani et al.
Background: Triplet therapy (encorafenib, cetuximab, and binimetinib) is recommended in Japan for BRAF V600E mutated metastatic colorectal cancer (mCRC) patients with poor prognostic factors (PFs) based on subgroup analys...
Phase I Trial of Binimetinib Plus Hydroxychloroquine in Patients with Previously Treated Metastatic Pancreatic Cancer [0.03%]
一项评估Binimetinib联合羟氯喹治疗既往经治的转移性胰腺导管癌患者I期临床试验
S Daniel Haldar,Fen Saj,So Jung Hong et al.
S Daniel Haldar et al.
Background: Dual mitogen-activated protein kinase (MAPK) pathway and autophagy inhibition shows synergistic antitumor activity in preclinical models of RAS-mutant cancers. We hypothesized that autophagy blockade with hydr...
Triangulating Associations Between Fruit Intake and Lung Cancer Risk: Evidence from GBD Estimates, Mendelian Randomization, and Real-World Validation [0.03%]
基于GBD估算、孟德尔随机化和现实世界验证的水果摄入与肺癌风险关联的研究
Mengqing Liu,Qilin Hu,Xinyue Zhang et al.
Mengqing Liu et al.
Background: Lung cancer is the leading cause of cancer-related deaths globally, with dietary factors such as low fruit intake potentially contributing to regional disparities. However, establishing causality remains chall...
Atezolizumab and Motixafortide, Cobimetinib or Simlukafusp Alfa in Pretreated Advanced Pancreatic Cancer: Phase I/IIb MORPHEUS-PDAC Umbrella Study [0.03%]
对于先前接受过治疗的晚期胰腺癌患者，阿特珠单抗联合马昔替坦或康明替尼或西姆利尤姆 flapα 的一期/二期伞式研究（MORPHEUS-PDAC）
Gulam A Manji,Vincent Chung,Do-Youn Oh et al.
Gulam A Manji et al.
Background: The MORPHEUS platform comprised multiple open-label, randomized, phase Ib/II trials to identify early signals with different treatment combinations across multiple cancers. MORPHEUS-PDAC (NCT03193190) evaluate...
Cognitive changes associated with chemotherapy in breast cancer. An assessment of social cognition and executive functions in Peruvian patients [0.03%]
乳腺癌患者化疗相关的认知变化。对秘鲁患者的社交认知和执行功能的评估
Sandro Casavilca-Zambrano,Nilton Custodio,Ruddy Liendo-Picoaga et al.
Sandro Casavilca-Zambrano et al.
Background: Cognitive impairment related to chemotherapy-commonly referred to as "chemo brain"-is a well-documented phenomenon among breast cancer patients. These impairments affect memory, attention, executive function, ...
Computationally Assisted Patient Finding for Navigation to Optimize Pancreatic Cancer Care Access [0.03%]
计算辅助患者定位导航以优化胰腺癌护理的获取权限
Daniel A King,Kristen M John,Joseph Tenner et al.
Daniel A King et al.
Background: Patient navigators are increasingly utilized in cancer care but ensuring patients are properly identified and referred to navigators is a significant challenge. The primary objective was to compare time from r...