Timothy A Yap,Fiona Simpkins,Marie Porte et al.
Timothy A Yap et al.
Synthetic lethality is a genetic phenomenon in which the simultaneous presence of two different genetic alterations impairs cellular viability, whereas a single gene defect is compatible with cellular survival. Importantly, targeting such s...
Climate Change and Environmental Exposures Across the Cancer Continuum: Implications for Oncology [0.03%]
气候变化与癌症全程的环境暴露：对肿瘤学的影响
Robert A Hiatt,Jefferey L Burgess,Prashant Mathur et al.
Robert A Hiatt et al.
Climate change is here and having a major impact on health, including cancer. Climate change is altering environmental exposures and modifying the frequency, intensity, and behavior of extreme weather events, introducing new challenges to c...
Clement A Adebamowo,Karen Canfell,Sally N Adebamowo et al.
Clement A Adebamowo et al.
Cancer is a leading and growing cause of morbidity and mortality worldwide, with an estimated 20 million new cases and 9.7 million deaths in 2022 and projections of substantially greater burden over coming decades. A large fraction of this ...
Quality Oncology Practice in Resource-Limited Settings: The Role and Impact of Best Practice Models [0.03%]
资源有限情况下的优质肿瘤实践：最佳实践模式的作用及影响
Abdul-Rahman Jazieh,Naghib Bogere,Gerardo Antonio Umanzor Funez et al.
Abdul-Rahman Jazieh et al.
In low- and middle-income countries (LMICs), resources for cancer care are limited and access to quality cancer care can be difficult. Access to cancer care is also limited in rural areas of developed countries. The increasing cancer burden...
Now or Later? Defining the Ideal Time for Surgical Cytoreduction in Advanced Ovarian Cancer [0.03%]
现在还是以后？确定晚期卵巢癌手术减瘤的 ideal 时间点
Kristin Bixel,Alexander Olawaiye,Margaret Flanigan et al.
Kristin Bixel et al.
Ovarian cancer is the most lethal gynecologic malignancy in the United States, with more than 20,000 new cases and 12,730 deaths estimated in 2025. Surgical cytoreduction and platinum-based chemotherapy are critical in the management of adv...
Smoldering Multiple Myeloma: From Clinical to Immunogenomic Risk Stratification and Therapeutic Implications of Early Intervention [0.03%]
smoldering多发性骨髓瘤：从临床到免疫基因组风险分层以及早期干预的治疗意义
Nizar J Bahlis,María V Mateos,Ajay K Nooka
Nizar J Bahlis
Smoldering multiple myeloma (SMM) is an asymptomatic precursor state that precedes the development of symptomatic active MM. Newer immunogenomic data highlight the monoclonal gammopathy of undetermined significance-SMM-MM spectrum as a cont...
Lung Cancer Screening and Prevention: Beyond Conventional Strategies in a Rapidly Changing Global Milieu [0.03%]
肺癌筛查与预防：超越传统策略，应对快速变化的全球环境
Teresa Gorría,Nicola Marino,Maria Alejandra Montoya Rubiano et al.
Teresa Gorría et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide despite advances in early detection and treatment. Furthermore, its epidemiology has undergone a profound transformation, necessitating a radical and comprehensive ...
Evolving Treatment Paradigms in Hormone Receptor-Positive, Human Epidermal Growth Factor 2-Negative Metastatic Breast Cancer [0.03%]
激素受体阳性、人表皮生长因子受体阴性乳腺癌转移的治疗方法的发展变迁
Sara Soliman,Ryan Zitter,Stephanie Walker et al.
Sara Soliman et al.
Hormone receptor-positive, human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (MBC) represents the most common subtype of MBC and has undergone substantial therapeutic evolution. Treatment has shifted from sequential e...
Biomarkers for Diagnosis, Risk Stratification, and Immunotherapy of Pediatric Solid Tumors [0.03%]
儿童实体瘤诊断、危险分层和免疫治疗的生物标志物
Ewa Koscielniak,Katie Janeway,Stephen Gottschalk
Ewa Koscielniak
There is a continued need to accurately diagnose, risk stratify, select treatment, and develop immunotherapies for extracranial pediatric solid tumors, and biomarkers are uniquely poised to meet this need. In most pediatric solid tumors, bi...
From Silos to Synergy: Building Resilient Multidisciplinary Oncology Teams [0.03%]
从各自为战到协同合作：构建富有韧性的肿瘤学多学科团队
Raymond Liu,Lidia Schapira,Sheetal Kircher et al.
Raymond Liu et al.
Modern cancer care is highly complex and interdependent, requiring coordination across specialties, settings, and time points. When interdependence is not intentionally managed, care delivery becomes fragmented, resulting in delays, ineffic...