Advanced Triple-Negative Breast Cancer: Emerging Therapies and a Changing Treatment Landscape [0.03%]
三阴性乳腺癌的新兴疗法及治疗现状变迁
Maeve A Hennessy,Elizabeth Terman,Damé Idossa et al.
Maeve A Hennessy et al.
Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 overexpression. Historically, treatment options for TNBC have been limited, bec...
Less Is More, But Me-Too Should Not Be the Strategy for Lung Cancer Treatment in 2026 [0.03%]
减而不简，“同质化”不该是2026年肺癌治疗的发展策略
Martina Bortolot,Stephanie P L Saw,Erica Pietroluongo et al.
Martina Bortolot et al.
Although immune checkpoint inhibitors (ICIs) and targeted therapies (TTs) have transformed the treatment of non-small cell lung cancer (NSCLC) across disease stages, real-world access remains highly unequal worldwide. Persistent cost barrie...
From Passion to Persistence: Nurturing Idealistic Roots to Extinguish Burnout [0.03%]
从激情到坚持：培育理想主义根基以消除职业耗竭
Sabe Sabesan,Wendy Oldenmenger,Mirjam Crul et al.
Sabe Sabesan et al.
Oncology clinicians often enter oncology with a strong sense of passion rooted in curiosity, service, and early formative experiences. Over time, however, this passion is tested by escalating clinical complexity, administrative burden, work...
Tailoring Management for Invasive Lobular Carcinoma: Imaging, Surgical Treatment, and Systemic Therapy Considerations [0.03%]
侵袭性小叶癌的诊治特点：影像学、手术及系统治疗考虑因素
Rita A Mukhtar,Matthew F Covington,Kristina Fanucci et al.
Rita A Mukhtar et al.
Invasive lobular carcinoma (ILC) represents the most common special subtype of breast cancer. Studies show challenges with imaging, surgical therapy, and systemic therapy selection, arguing for the need for improved treatment personalizatio...
Luis G Medina,Firas Hatoum,Nahuel Paesano et al.
Luis G Medina et al.
Penile squamous cell carcinoma (PSCC) is a rare malignancy that displays profound disparities in incidence, access to care, and clinical outcomes rooted in economic, social differences, and cultural practices. PSCC has been linked to high t...
Joy Li,Leslie Ballas,Pooja Ghatalia
Joy Li
Muscle-invasive bladder cancer (MIBC) has historically been managed with neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy (RC), a strategy associated with substantial morbidity and long-term quality-of-life implicatio...
Balancing Cure and Quality of Life: Navigating Functional Outcomes in Localized Prostate Cancer [0.03%]
兼顾治愈与生活质量：局限性前列腺癌的功能预后管理
Abby L Grier,Erik Briers,Randie E White et al.
Abby L Grier et al.
Current guidelines for clinically localized prostate cancer offer a wide range of management options, from active surveillance to surgery and radiation therapy (RT). Treatment selection depends on tumor characteristics, overall health, and ...
Neoadjuvant Systemic Therapy in Kidney and Bladder Cancer: Current Evidence and Emerging Paradigms [0.03%]
肾癌和膀胱癌的新辅助全身治疗：现有证据与新范式
Rana R McKay,Asha Tipirneni,Rick Bangs et al.
Rana R McKay et al.
Neoadjuvant systemic therapy has emerged as a strategy to improve outcomes in high-risk localized genitourinary malignancies. In bladder cancer, neoadjuvant cisplatin-based chemotherapy with or without immunotherapy is standard of care, wit...
Beyond Chronologic Age: Frailty, Geriatric Assessment, and Personalized Care for Older Adults With Genitourinary Cancer [0.03%]
超越年龄：老年泌尿系统癌症患者的脆弱性、老年评估和个性化护理
Peter L Lee,Carla Fitch,Jason A Efstathiou et al.
Peter L Lee et al.
Frailty captures multiple physical, mental, and social vulnerabilities that affect older adults with cancer and is associated with clinical outcomes. A major challenge in oncology is how best to avoid undertreatment or overtreatment by tail...
Yi Song,Meenakshi Jeeva,Robert P Liddell et al.
Yi Song et al.
Approximately 25% of patients with colorectal cancer present with metastatic disease to the liver at diagnosis, and about 50% develop liver metastases at some point during the course of the disease. Surgical resection of hepatic metastases ...