Chronic Lymphocytic Leukemia Through the Spectrum: Frontline Therapy, Sequencing With Subsequent Therapy, and Treatment of Double-Refractory Patients [0.03%]
慢性淋巴细胞白血病的全程管理：初治、序贯疗法和复发后的治疗策略
Anna Maria Frustaci,Alessandra Tedeschi,Alexander F Vom Stein et al.
Anna Maria Frustaci et al.
The rapid development of novel agents and combinations in chronic lymphocytic leukemia/small lymphocytic lymphoma has led to multiple options for frontline therapy and relapse, including continuous therapy and fixed duration regimens. The c...
Shalini Fernando,Van Morris,James Yu et al.
Shalini Fernando et al.
Squamous cell carcinoma of the anal canal (SCAC) is a rare, human papillomavirus-driven malignancy with a rising global incidence and an increasingly dynamic therapeutic landscape. This review summarizes recent advances and current evidence...
Measurable Residual Disease in Pediatric Acute Leukemia: Application and Interpretation of Current and Emerging Methodologies [0.03%]
儿童急性白血病中可测量的残留疾病：当前和新兴方法的应用与解读
Lisa Eidenschink Brodersen,Alexandra E Kovach,Jan Zuna
Lisa Eidenschink Brodersen
Measurable/minimal residual disease (MRD) monitoring is an essential component of modern treatment protocols for ALL and AML. Early response to therapy, as measured by MRD levels at defined time points during treatment, serves as an importa...
Global Disparities in Cancer Care for Conflict-Affected Populations: Africa's Neglected Crisis [0.03%]
冲突影响地区癌症护理的全球差异：被忽视的非洲危机
Nazik Hammad,Omar Abdihamid,Moawia Mohammed Ali Elhassan et al.
Nazik Hammad et al.
Cancer care in conflict-affected settings represents a growing yet underrecognized global health crisis, disproportionately affecting populations in low- and middle-income countries, particularly in Africa. With over 130 million people forc...
Navigating Treatment Decisions in Early-Stage Hormone Receptor-Positive Breast Cancer [0.03%]
早期激素受体阳性乳腺癌治疗决策指南
Eitan Amir,Tyler Kristoff,Catherine Blaha et al.
Eitan Amir et al.
Treating patients with early-stage hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer is increasingly complex, driven by a growing array of therapeutic options, heterogeneous clinical benefit across p...
Understanding Contemporary Challenges in the Care of Patients With Early-Onset Cancer: Epidemiologic Trends, Patient Well-Being, Oncofertility, and Cancer Survivorship [0.03%]
当代早期发病癌症患者的护理面临的挑战：流行病学趋势、患者健康状况、肿瘤生殖学和生存率问题的理解
Cristiane Bergerot,Laura V M Baum,Ih-Jane Yang et al.
Cristiane Bergerot et al.
Cancer diagnosed before age 50 years, commonly referred to as early-onset or young-onset cancer, is an increasingly recognized global public health challenge, with rising incidence across multiple tumor types, including colorectal, breast, ...
Gareth J Morgan,Dennis D Lee,Nisha S Joseph et al.
Gareth J Morgan et al.
Despite therapeutic progress, there has been little improvement in the outcome of the 15%-25% of newly diagnosed high-risk multiple myeloma (HRMM), which is characterized by early treatment resistance and very poor survival. HRMM is a subst...
Yin Ting Cheung,Mu-Hsing Ho,Joanna Fardell et al.
Yin Ting Cheung et al.
Cancer-related cognitive impairment (CRCI) is common and multifactorial in nature with the cancer itself, various treatment modalities, as well as socioenvironmental, biobehavioral, and lifestyle factors all potentially contributing to cogn...
Applying Quality Oncology Practices in Africa: Lean Implementation, Real Impact [0.03%]
品质肿瘤实践在非洲的应用：精实实施，真实影响
Naghib Bogere,David Mwiine,Judith Asasira et al.
Naghib Bogere et al.
Background: In many low- and middle-income countries, expanding access to cancer services has been a major priority. Yet, patient outcomes increasingly depend not only on whether services exist but on how care is organize...
Arjun Ravishankar,Ganesan Ramamoorthi,Tobias Weiss et al.
Arjun Ravishankar et al.
Metastasis is the main cause of cancer death and is driven by the systemic formation of premetastatic niches and immune sanctuaries that protect disseminated cancer cells (DCCs) from immune surveillance and therapy. This review explores the...