Sumithra J Mandrekar,Suzanne E Dahlberg,Richard Simon
Sumithra J Mandrekar
Clinical trial design strategies have evolved over the past few years as a means to accelerate the drug development process so that the right therapies can be delivered to the right patients. Basket, umbrella, and adaptive enrichment strate...
The global conduct of cancer clinical trials: challenges and opportunities [0.03%]
癌症临床试验的全球开展：挑战与机遇
Carlos H Barrios,Gustavo Werutsky,Jeovany Martinez-Mesa
Carlos H Barrios
The nature of clinical research has changed substantially over the last 2 decades, evolving from being centered almost exclusively in developed countries to a more global scenario that is increasingly involving less developed regions of the...
Stuart M Lichtman
Stuart M Lichtman
The overall aging of the population has resulted in a marked increase in the number of older patients with cancer. These patients have specific needs that are different from those of the younger population. Cancer clinical trials have inclu...
What Can We Learn about Antibody-Drug Conjugates from the T-DM1 Experience? [0.03%]
从T-DM1的经验中我们可以了解哪些关于抗体药物偶联物的知识？
Francisco J Esteva,Kathy D Miller,Beverly A Teicher
Francisco J Esteva
Antibody conjugates are a diverse class of therapeutics that consist of a cytotoxic agent linked covalently to an antibody or antibody fragment directed toward a specific cell surface target expressed by tumor cells. The notion that antibod...
Christian Mawrin,Caroline Chung,Matthias Preusser
Christian Mawrin
Meningiomas are the most frequently occurring intracranial tumors. They are characterized by a broad spectrum of histopathologic appearance. Molecular alterations driving meningioma development, which affect the NF2 gene, are found in rough...
Metabolism and oxidative stress response pathways in kidney cancer: a tale of chance and necessity [0.03%]
肾脏癌中的代谢和氧化应激反应通路:机遇与必然的故事
Carole Sourbier,Ramaprasad Srinivasan,W Marston Linehan
Carole Sourbier
Over 270,000 patients are affected with kidney cancer worldwide and 120,000 died from this disease in 2014. Over the last few decades, important progress has been made in our understanding of the genetic and molecular mechanisms underlying ...
Application of molecular biology to individualize therapy for patients with liposarcoma [0.03%]
分子生物学在个性化治疗脂肪肉瘤患者中的应用
Gulam Abbas Manji,Samuel Singer,Andrew Koff et al.
Gulam Abbas Manji et al.
Liposarcomas are one the most common of over 50 histologic subtypes of soft tissue sarcomas that are mostly resistant to chemotherapy. Histologically, liposarcomas themselves are heterogeneous and fall into four distinct subtypes: well-diff...
Using social media to learn and communicate: it is not about the tweet [0.03%]
利用社交媒体学习和沟通：重要的不是推文本身
Michael A Thompson
Michael A Thompson
Social media can be defined as the use of media to interact with social networks. Social media is not about the content of the tweet, inasmuch as the technologies and social media platforms influence how content is generated, disseminated, ...
Approaches to reduce the long-term burden of treatment-related complications in survivors of childhood cancer [0.03%]
减少儿童期癌症幸存者长期治疗相关并发症负担的方法
Saro H Armenian,Leontien C Kremer,Charles Sklar
Saro H Armenian
Advances in diagnostics, treatment strategies, and supportive care have contributed to a marked improvement in outcomes for children with cancer. This has resulted in a growing number of long-term childhood cancer survivors. Currently there...
Challenges to Standardizing the Care for Adult Cancer Survivors: Highlighting ASCO's Fatigue and Anxiety and Depression Guidelines [0.03%]
成人癌症幸存者标准化护理的挑战：强调ASCO疲劳和焦虑及抑郁指南
Ann H Partridge,Paul B Jacobsen,Barbara L Andersen
Ann H Partridge
There are over 14 million survivors of cancer living in the United States alone and tens of millions more worldwide, with this population expected to nearly double in the next decade. The successes of prevention, early detection, and better...