Compassion, compassion fatigue, and burnout: key insights for oncology professionals [0.03%]
同情心、同情疲劳和职业耗竭：肿瘤学专业人士的关键见解
Anthony L Back,Paul F Deignan,Patricia A Potter
Anthony L Back
When cancer care clinicians become stressed, sad, isolated--and unaware of this--they are placing themselves at risk for burnout and their patients at risk for suboptimal care. Despite their best intentions, clinicians can sink from a healt...
John V Cox,Jeffery C Ward,John C Hornberger et al.
John V Cox et al.
Patients and payers (government and private) are frustrated with the fee-for-service system (FFS) of payment for outpatient health services. FFS rewards volume and highly valued services, including expensive diagnostics and therapeutics, ov...
Biological and therapeutic implications of the BRAF pathway in histiocytic disorders [0.03%]
BRAF信号通路在组织细胞疾病中的生物学及治疗学意义分析
Robert J Arceci
Robert J Arceci
Langerhans cell histiocytosis (LCH) has historically evolved in its classification from a primary immune dysregulatory disorder to what current evidence supports as a dendritic cell neoplasm with an immune-inflammatory component. A key part...
David Malkin,Kim E Nichols,Kristin Zelley et al.
David Malkin et al.
Our understanding of hereditary cancer syndromes in children, adolescents, and young adults continues to grow. In addition, we now recognize the wide variation in tumor spectrum found within each specific cancer predisposition syndrome incl...
Mark W Kieran
Mark W Kieran
The role of BRAF in adult malignancy has been well documented over the last decade and recent data have extended these findings to a number of pediatric cancers. In this and the accompanying articles, we will review the importance of the BR...
Alberto S Pappo
Alberto S Pappo
Pediatric melanoma is rare and given the diagnostic challenges it presents in this age group, it is difficult to interpret the literature describing its natural history and outcome. Recent genomic analysis demonstrates that conventional mel...
Tara O Henderson,Kirsten K Ness,Harvey Jay Cohen
Tara O Henderson
There are almost 14-million cancer survivors in the United States and the population is growing. Almost two-thirds of these survivors are age 65 or older. Given this, it is imperative to understand the impact of cancer and its therapies on ...
Frontline approach to metastatic BRAF-mutant melanoma diagnosis, molecular evaluation, and treatment choice [0.03%]
转移性BRAF突变型黑色素瘤的诊断、分子评估和治疗选择的前线方法
Paul B Chapman,Axel Hauschild,Vernon K Sondak
Paul B Chapman
An estimated 76,100 patients will be diagnosed with invasive melanoma in the United States in 2014, and 9,710 patients will die from the disease. In almost all cases, the cause of death is related to the development of widespread metastatic...
Manisha Thakuria,Nicole R LeBoeuf,Guilherme Rabinowits
Manisha Thakuria
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cutaneous malignancy, with a predilection for sun-exposed sites in elderly patients. Despite an incidence 30 times less than that of melanoma, its disease-specific mortalit...
Developments in the treatment of locally advanced and metastatic squamous cell carcinoma of the skin: a rising unmet need [0.03%]
皮肤鳞状细胞癌局部晚期和转移性治疗的进展：日益增长的未满足需求
Paul Palyca,Vadim P Koshenkov,Janice M Mehnert
Paul Palyca
Squamous cell carcinoma of the skin (SCCS) is a common malignancy with potentially devastating consequences in patients with locally advanced or metastatic disease. Its rising incidence, primarily a result of an aging population and increas...