Jorge Ferreira
Jorge Ferreira
Generation and characterization of humanized CD4 knock-in mice expressing chimeric mouse/human CD4 protein [0.03%]
人源化CD4嵌合敲入小鼠的构建及其表型分析
Ka-Man Kam,Tsz-En Shiu,Chien-Ming Hsieh et al.
Ka-Man Kam et al.
Humanized mouse models have become indispensable tools for investigating human gene function and disease modeling. However, conventional transgenic approaches carry the risk of unforeseen biological consequences. Here, to address this conce...
Establishment and functional analysis of an inducible Apoc2-knockout mouse model to investigate the role of Apoc2 in normal hematopoiesis [0.03%]
建立并功能分析诱导型Apoc2基因敲除小鼠模型以研究Apoc2在正常造血中的作用
Xiaochen Zhang,Ritu Chandwani,Mateusz Pospiech et al.
Xiaochen Zhang et al.
Apolipoprotein C2 (APOC2) has been identified as a potential therapeutic target for acute myeloid leukemia, but its impact on normal hematopoiesis remains unclear. Here we generated a global inducible Apoc2 knockout (KO) mouse model by bree...
Structural osteoarthritis pathogenesis correlates with distinct pain and dysfunction profiles after ACL injury in rats [0.03%]
膝关节前交叉韧带损伤后结构性骨关节炎病理与特定的疼痛和功能障碍表型相关性研究
Nicholas M Pancheri,Nisha Kyathsandra,Jake Heinonen et al.
Nicholas M Pancheri et al.
Post-traumatic osteoarthritis (PTOA) frequently arises following knee injury, such as anterior cruciate ligament (ACL) rupture. Small animal models are critical for studying PTOA pathology and translating therapeutic interventions. Here our...
Male reproductive phenotype in cystic fibrosis: comparison of existing animal models [0.03%]
囊性纤维化动物模型的男性生殖表型比较研究
Angèle Boursier,Charles-Henry Cottart,Aissatu Balde-Camara et al.
Angèle Boursier et al.
In men, cystic fibrosis (CF) leads to infertility in over 95% of cases, due to early and progressive atresia of the vas deferens, resulting in obstructive azoospermia. The advent of highly effective modulator therapy has enabled more men wi...
Jorge Ferreira
Jorge Ferreira
Alexandra Le Bras
Alexandra Le Bras
Alexandra Le Bras
Alexandra Le Bras
Jorge Ferreira
Jorge Ferreira
Jorge Ferreira
Jorge Ferreira