Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks [0.03%]
多实验室临床前评估网络中潜在疾病干预措施的随机盲法对照评价方法
Jessica Lamb,Karisma Nagarkatti,Marcio A Diniz et al.
Jessica Lamb et al.
Science faces a reproducibility crisis, and public trust in science declines when large clinical trials, which had been qualified by promising preclinical studies, fail. While some clinical trial designs may have been inadequate, preclinica...
Retinal phenotype of APOB100 transgenic mice on a Western diet with human-like hyperlipidemia and cholesterol crystals in the retina and choroid [0.03%]
载人APOB100转基因小鼠的视网膜表型及其西方饮食引起的类人类高脂血症和视网膜脉络膜胆固醇结晶沉着
Nicole El-Darzi,Tim F Dorweiler,Natalia Mast et al.
Nicole El-Darzi et al.
Drusen and subretinal drusenoid deposits, the pathognomonic lesions for age-related macular degeneration (AMD), are rich in cholesterol. Yet, AMD is not consistently linked to plasma lipids. Here wild-type and human apolipoprotein B100-expr...
PiggyBac-mediated transgenesis and CRISPR-Cas9 knockout in the greater wax moth, Galleria mellonella [0.03%]
大蜡螟(Galleriamellonella)的PiggyBac介导的转基因和CRISPR-Cas9敲除
James C Pearce,Jennie S Campbell,Joann L Prior et al.
James C Pearce et al.
The larvae of the greater wax moth, Galleria mellonella, are gaining prominence as a versatile nonmammalian in vivo model to study host-pathogen interactions. Their ability to be maintained at 37 °C, coupled with a broad susceptibility to ...
Jorge Ferreira
Jorge Ferreira
Alexandra Le Bras
Alexandra Le Bras
Jorge Ferreira
Jorge Ferreira
Alexandra Le Bras
Alexandra Le Bras
Jorge Ferreira
Jorge Ferreira
Jorge Ferreira
Jorge Ferreira
Alexandra Le Bras
Alexandra Le Bras