Neuropixels go ultra [0.03%]
超神经元像素技术
Luis A Mejia
Luis A Mejia
Henrietta Howells
Henrietta Howells
Composing behavior [0.03%]
行为创作
William P Olson
William P Olson
Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion [0.03%]
小鼠大脑发育的空间转录组学免疫图谱揭示了母体免疫激活和微生物群耗竭的影响
Bharti Kukreja,Shin Jeon,Wuxinhao Cao et al.
Bharti Kukreja et al.
Immune molecules and their cognate receptors are developmentally regulated in brain and dynamically expressed in the context of neurodevelopmental disorders. Despite the importance of immune molecules to brain wiring, a comprehensive map of...
CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment [0.03%]
利用CRISPR敲除筛选发现神经元分化的关键基因和信号通路并鉴定PEDS1在神经发育中的作用
Alana Amelan,Stephan C Collins,Nadirah S Damseh et al.
Alana Amelan et al.
Neurodevelopmental disorders (NDDs) arise from disruptions in brain development, yet the underlying pathways remain incompletely understood. Here we demonstrate that genome-wide CRISPR knockout screens in mouse embryonic stem cells differen...
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration [0.03%]
TGFβ信号介导小胶质细胞对时空限制的髓磷脂退行的抗逆性
Keying Zhu,Yun Liu,Jin-Hong Min et al.
Keying Zhu et al.
Microglia survey and regulate central nervous system myelination during embryonic development and adult homeostasis. However, whether microglia-myelin interactions are spatiotemporally regulated remains unexplored. Here, by examining spinal...
Position-independent emergence of neocortical neuron molecular identity, connectivity and function [0.03%]
位置无关的新皮层神经元分子特征、连接和功能的出现
Sergi Roig-Puiggros,Maëlle Guyoton,Dmitrii Suchkov et al.
Sergi Roig-Puiggros et al.
Brain architectures vary widely across species, yet how neuronal positioning constrains the type of circuits that can be made, and their function, remains poorly understood. Here we examine how neuronal position affects molecular identity, ...
Leveraging insights from neuroscience to build adaptive artificial intelligence [0.03%]
借鉴神经科学的见解来构建自适应的人工智能
Mackenzie Weygandt Mathis
Mackenzie Weygandt Mathis
Biological intelligence is inherently adaptive-animals continually adjust their actions in response to environmental feedback. However, creating adaptive artificial intelligence (AI) remains a major challenge. The next frontier is to go bey...
Sebastian A Bruijns;International Brain Laboratory;Kcénia Bougrova,Inês C Laranjeira,Petrina Y P Lau et al.
Sebastian A Bruijns;International Brain Laboratory;Kcénia Bougrova et al.
Learning the contingencies of a task is difficult. Individuals learn in an idiosyncratic manner, revising their approach multiple times as they explore and adapt. Quantitative characterization of these learning curves requires a model that ...