Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy [0.03%]
利用直接重编程的患者衍生纹状体神经元模拟年龄相关的亨廷顿舞蹈病进展，强调自噬受损的重要性
Young Mi Oh,Seong Won Lee,Woo Kyung Kim et al.
Young Mi Oh et al.
Huntington's disease (HD) is an inherited neurodegenerative disorder with adult-onset clinical symptoms, but the mechanism by which aging drives the onset of neurodegeneration in patients with HD remains unclear. In this study we examined s...
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex [0.03%]
神经传递素系统与人类新皮层的结构和功能组织之间的映射关系图示
Justine Y Hansen,Golia Shafiei,Ross D Markello et al.
Justine Y Hansen et al.
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehen...
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states [0.03%]
基于CRISPRi的人类诱导多能干细胞来源星形胶质细胞筛选揭示不同炎症活化状态的调节因子
Kun Leng,Indigo V L Rose,Hyosung Kim et al.
Kun Leng et al.
Astrocytes become reactive in response to insults to the central nervous system by adopting context-specific cellular signatures and outputs, but a systematic understanding of the underlying molecular mechanisms is lacking. In this study, w...
A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry [0.03%]
单细胞质谱流式细胞术绘制外周感觉神经元分化和成熟的发育图谱
Austin B Keeler,Amy L Van Deusen,Irene C Gadani et al.
Austin B Keeler et al.
Precisely controlled development of the somatosensory system is essential for detecting pain, itch, temperature, mechanical touch and body position. To investigate the protein-level changes that occur during somatosensory development, we pe...
Altruism and social rewards [0.03%]
利他主义与社会回报
Hee-Sup Shin
Hee-Sup Shin
Alex C Kwan,David E Olson,Katrin H Preller et al.
Alex C Kwan et al.
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in perception, cognition and mood. In this review, we focus on the basic neurobiology underlying the action of psychedelic drugs. We first discuss chemistry, ...
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging [0.03%]
CD8+t细胞诱导小胶质细胞和少突胶质细胞在白质老化中的干扰素反应
Tuğberk Kaya,Nicola Mattugini,Lu Liu et al.
Tuğberk Kaya et al.
A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. In the present study, we found age-related alterations of oligodendrocyte cell...
Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice [0.03%]
互惠的皮层-杏仁核连接调控小鼠的亲社会和自私选择
Diego Scheggia,Filippo La Greca,Federica Maltese et al.
Diego Scheggia et al.
Decisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We ...
Siwei Zhang,Alan R Sanders,Jubao Duan
Siwei Zhang
How genetic and environmental risk factors interact to trigger the development of post-traumatic stress disorder (PTSD) remains largely unknown. Seah et al. model stress hypersensitivity as a potential mechanism by examining transcriptomic ...
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression [0.03%]
利用人类神经元建模PTSD中的基因-环境互作并揭示诊断特异性的糖皮质激素诱导的基因表达
Carina Seah,Michael S Breen,Tom Rusielewicz et al.
Carina Seah et al.
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, we compared transcriptional responses to ...