Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease [0.03%]
阿尔茨海默病小鼠模型单细胞转录组与组织病理学的整合原位图谱绘制
Hu Zeng,Jiahao Huang,Haowen Zhou et al.
Hu Zeng et al.
Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However, understanding the spatiotemporal dynamics underlying pathology can shed light on disease mechanis...
Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout' of visual input [0.03%]
映射丘脑投射到单个L2/3锥体神经元并模拟其视觉输入“读取”
Aygul Balcioglu,Rebecca Gillani,Michael Doron et al.
Aygul Balcioglu et al.
The thalamus is the main gateway for sensory information from the periphery to the mammalian cerebral cortex. A major conundrum has been the discrepancy between the thalamus's central role as the primary feedforward projection system into t...
Author Correction: A shared disease-associated oligodendrocyte signature among multiple CNS pathologies [0.03%]
作者更正：多发性CNS病理损伤相关少突胶质细胞的共同特征签名
Mor Kenigsbuch,Pierre Bost,Shahar Halevi et al.
Mor Kenigsbuch et al.
Published Erratum
Nature neuroscience. 2023 Mar;26(3):528. DOI:10.1038/s41593-023-01266-y 2023
Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks [0.03%]
皮层谷氨酸能投射神经元类型贡献于不同的功能亚网络
Hemanth Mohan,Xu An,X Hermione Xu et al.
Hemanth Mohan et al.
The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural network dynamics across broad cortical areas yet with projection-neuron-type resolution in real t...
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making [0.03%]
金字塔细胞类型在决策过程中驱动皮层的功能性活动模式多样化
Simon Musall,Xiaonan R Sun,Hemanth Mohan et al.
Simon Musall et al.
Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) types have been observed within cortical areas, but it is not known...
A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain [0.03%]
生成和维持慢性疼痛必不可少的一条睡眠期活跃的基底-皮层通路
Hang Zhou,Miao Li,Ruohe Zhao et al.
Hang Zhou et al.
Poor sleep is associated with the risk of developing chronic pain, but how sleep contributes to pain chronicity remains unclear. Here we show that following peripheral nerve injury, cholinergic neurons in the anterior nucleus basalis (aNB) ...
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein [0.03%]
可溶性α-突触核蛋白的翻译后修饰调节病理性α-突触核蛋白的放大效应
Shujing Zhang,Ruowei Zhu,Buyan Pan et al.
Shujing Zhang et al.
Cell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this has focused on pathological protein seeds, but how their normal counterparts, which are con...
Julia Cox,Adelaide R Minerva,Weston T Fleming et al.
Julia Cox et al.
While there is emerging evidence of sex differences in decision-making behavior, the neural substrates that underlie such differences remain largely unknown. Here we demonstrate that in mice performing a value-based decision-making task, wh...
Massively parallel identification of mRNA localization elements in primary cortical neurons [0.03%]
在初级皮质神经元中大量并行识别mRNA定位元素
Samantha Mendonsa,Nicolai von Kügelgen,Sayaka Dantsuji et al.
Samantha Mendonsa et al.
Cells adopt highly polarized shapes and form distinct subcellular compartments in many cases due to the localization of many mRNAs to specific areas, where they are translated into proteins with local functions. This mRNA localization is me...
Gregor Bieri,Adam B Schroer,Saul A Villeda
Gregor Bieri
Aging induces molecular, cellular and functional changes in the adult brain that drive cognitive decline and increase vulnerability to dementia-related neurodegenerative diseases. Leveraging systemic and lifestyle interventions, such as het...