Accelerated Cognitive Decline in Late Life Depression: The Role of Amyloid-β, Cortico-Limbic Volume, and White Matter Hyperintensities [0.03%]
老年抑郁症加速的认知衰退：淀粉样蛋白、皮层-边缘叶体积和高信号白质斑点的作用
Emma Rhodes,Philip S Insel,Michelle Kassel et al.
Emma Rhodes et al.
Objectives: Late life depression (LLD) is associated with cognitive impairment and dementia, but studies of cognitive decline in LLD have been confounded by underlying Alzheimer's disease (AD). We evaluated longitudinal c...
A Journey Toward Therapeutic Change in Depression: An Early Career Scientific Autobiography [0.03%]
抑郁症治疗性变化的探索之旅——早期职业生涯科研自传
Nili Solomonov
Nili Solomonov
Acceptability of Euthanasia for People With Dementia: Perspectives of Clinicians From Six Countries [0.03%]
六国临床医生对于痴呆患者安乐死接受度的观点
Jingyuan Xu 须静媛,Hanneke J A Smaling,Miharu Nakanishi et al.
Jingyuan Xu 须静媛 et al.
Objectives: Euthanasia for people with dementia is controversial and clinicians should decide how to respond to euthanasia requests. The authors aimed to investigate clinicians' perspectives on the acceptability of euthan...
Robert Kohn
Robert Kohn
The UN has produced various declarations addressing the human rights of older persons. The UN does not have a specific treaty or convention regarding human rights of older persons as part of its human rights system. Recently the Open-ended ...
Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability [0.03%]
氯胺酮和艾司氯胺酮治疗晚发抑郁症的疗效、安全性和耐受性系统综述
Ronesh Sukhdeo,Jocelyn K Tamura,Christine E Dri et al.
Ronesh Sukhdeo et al.
Ketamine has emerged as a promising treatment for major depression, though its efficacy and safety remain incompletely characterized in older adults. This systematic review synthesizes current evidence for ketamine in geriatric depression. ...
Is the Time Right to Start Testing if Late-Onset Depression is Associated With the Development of an α-Synucleinopathy Like Parkinson's Disease? A Double Systematic Review and Meta-Analysis [0.03%]
现在测试晚发性抑郁是否与类似帕金森病的α-突触核蛋白病发病有关的最佳时机吗？一项双重系统评价和荟萃分析
Jan Booij,Rik Schalbroeck,Madeleine Wartenhorst et al.
Jan Booij et al.
Parkinson's disease (PD) is characterized by two neurobiological markers: pathological α-synuclein and/or a dopaminergic deficit. Depression is common in PD, and may precede motor signs, particularly in late-onset depression (LOD). We cond...
Response to "The Evidence Base for Electroconvulsive Therapy (ECT) in Geriatric Depression" [0.03%]
有关电休克疗法（ECT）治疗老年抑郁症的证据基础的回答
Tor Arnison,Axel Nordenskjöld
Tor Arnison
Hearing Loss, Hearing Aid Use, and Neuropsychiatric Symptoms Among Persons Living With Dementia: Findings From NACC [0.03%]
听力损失、助听器使用和痴呆患者的神经精神症状：NACC研究结果
Ahjeetha Shankar,Emmanuel E Garcia Morales,Jeannie-Marie Leoutsakos et al.
Ahjeetha Shankar et al.
Objective: Hearing loss is a common comorbidity among persons living with dementia (PLWD), affecting >90% of individuals. Sensory impairments have been associated with an increased risk of neuropsychiatric symptoms (NPS),...
David L Coulter
David L Coulter