Safety, Tolerability, and Real-World Effectiveness of Intravenous Ketamine in Older Adults With Treatment-Resistant Depression: A Case Series [0.03%]
氯胺酮静脉输注治疗难治性抑郁障碍老年患者的疗效、安全性和耐受性：系列案例报告
Orly Lipsitz,Joshua D Di Vincenzo,Nelson B Rodrigues et al.
Orly Lipsitz et al.
Objective: To evaluate the safety, tolerability, and effectiveness of repeated doses of intravenous (IV) ketamine in older adults (i.e., ≥60 years of age) with treatment-resistant depression. ...
Depression and Dementia Risk: Research Findings That Are Shovel-Ready for Clinicians [0.03%]
抑郁症与痴呆症风险：临床医生可直接应用的研究成果
David C Steffens
David C Steffens
Depression and Increased Risk of Alzheimer's Dementia: Longitudinal Analyses of Modifiable Risk and Sex-Related Factors [0.03%]
抑郁症与阿尔茨海默病的发病风险：可改变因素和性别相关因素的纵向分析
Doyoung Kim,RuoDing Wang,Alex Kiss et al.
Doyoung Kim et al.
Objective: Our understanding of why older adults with depression are at increased risk of Alzheimer's disease (AD) remains incomplete. Most adults living with AD are women, and women have a near twofold lifetime risk of d...
Antidepressants May Not Be Enough When Frailty Complicates Depression in Late Life [0.03%]
老年抑郁症患者身体虚弱时单用抗抑郁药物可能效果不佳
Gary J Kennedy
Gary J Kennedy
Brainstem Pathologies Correlate With Depression and Psychosis in Parkinson's Disease [0.03%]
帕金森病患者脑干病理与抑郁和精神病的相关性研究
Nicole Mercado Fischer,Jared T Hinkle,Kate Perepezko et al.
Nicole Mercado Fischer et al.
Background: The pathological hallmarks of Parkinson's disease include intraneuronal Lewy bodies, neuronal loss, and gliosis. We aim to correlate Parkinson's disease neuropsychiatric symptoms, (e.g., depression, psychosis,...
Transient Cognitive Impairment and White Matter Hyperintensities in Severely Depressed Older Patients Treated With Electroconvulsive Therapy [0.03%]
难治性老年抑郁症电休克治疗后的认知损害及脑白质病变程度的关系研究
Margot J Wagenmakers,Kristof Vansteelandt,Eric van Exel et al.
Margot J Wagenmakers et al.
Background: Although electroconvulsive therapy (ECT) is a safe and effective treatment for patients with severe late life depression (LLD), transient cognitive impairment can be a reason to discontinue the treatment. The ...
J Barrie Shepherd
J Barrie Shepherd
Impact of Historical Intimate Partner Violence on Wellbeing and Risk for Elder Abuse in Older Women [0.03%]
往老年期过渡时亲密伴侣暴力对女性福祉的影响及其遭受虐待的风险
Monica Cations,Hannah A D Keage,Kate E Laver et al.
Monica Cations et al.
Objective: To assess the psychological impacts and risk for elder abuse associated with historical intimate partner violence (IPV) in older women. Design:...
Structural Brain Differences Between Cognitively Impaired Patients With and Without Apathy [0.03%]
伴有和不伴冷漠症状的轻度认知障碍患者的大脑结构差异研究
Nathan K Chan,Philip Gerretsen,M Mallar Chakravarty et al.
Nathan K Chan et al.
Objective: Since apathy increases in prevalence with severity of dementia pathology, we sought to distinguish concomitant neurodegenerative processes from brain differences associated with apathy in persons with mild cogn...