Kaushik P Venkatesh,Gabriel Brito,Maged N Kamel Boulos
Kaushik P Venkatesh
Health digital twins (HDTs) are virtual representations of real individuals that can be used to simulate human physiology, disease, and drug effects. HDTs can be used to improve drug discovery and development by providing a data-driven appr...
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders [0.03%]
靶向胆碱能受体对多巴胺系统的作用：治疗神经精神疾病的新的策略
Eric J Nunes,Nii A Addy,P Jeffrey Conn et al.
Eric J Nunes et al.
Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous disorders, including schizophrenia, substance use disorders, and mood-related disorders. The activity of midbrain DA neurons and DA release patterns...
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance [0.03%]
直接抑制K-RAS治疗癌症：进展、新见解和克服耐药性的策略
Ruth Nussinov,Hyunbum Jang
Ruth Nussinov
Here we discuss approaches to K-Ras inhibition and drug resistance scenarios. A breakthrough offered a covalent drug against K-RasG12C. Subsequent innovations harnessed same-allele drug combinations, as well as cotargeting K-RasG12C with a ...
Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward [0.03%]
单个常见基因变异体之外的药物基因组学：未来之路
Volker M Lauschke,Yitian Zhou,Magnus Ingelman-Sundberg
Volker M Lauschke
Interindividual variability in genes encoding drug-metabolizing enzymes, transporters, receptors, and human leukocyte antigens has a major impact on a patient's response to drugs with regard to efficacy and safety. Enabled by both technolog...
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics [0.03%]
脂蛋白(a)：结构、遗传性、相关心血管风险及新兴疗法
Erfan Tasdighi,Rishav Adhikari,Omar Almaadawy et al.
Erfan Tasdighi et al.
Lipoprotein(a) [Lp(a)] is a molecule bound to apolipoprotein(a) with some similarity to low-density lipoprotein cholesterol (LDL-C), which has been found to be a risk factor for cardiovascular disease (CVD). Lp(a) appears to induce inflamma...
High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions [0.03%]
高通量筛选技术在体外毒性试验中的应用：成就、挑战与未来方向
Caitlin Lynch,Srilatha Sakamuru,Masato Ooka et al.
Caitlin Lynch et al.
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of chemicals in use and the high rate of ...
Manuel Corpas,Moneeza K Siddiqui,Opeyemi Soremekun et al.
Manuel Corpas et al.
The association of an individual's genetic makeup with their response to drugs is referred to as pharmacogenomics. By understanding the relationship between genetic variants and drug efficacy or toxicity, we are able to optimize pharmacolog...
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health [0.03%]
长链欧米茄-3多不饱和脂肪酸在心血管健康中的利弊分析
Ivana Djuricic,Philip C Calder
Ivana Djuricic
The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in seafood, supplements, and concentrated pharmaceutical preparations. Prospective cohort studies demonstrate an association between h...
Shanelle R Shillingford,Anton M Bennett
Shanelle R Shillingford
Phosphatases and kinases maintain an equilibrium of dephosphorylated and phosphorylated proteins, respectively, that are required for critical cellular functions. Imbalance in this equilibrium or irregularity in their function causes unfavo...
Catherine Godson,Patrick Guiry,Eoin Brennan
Catherine Godson
Inflammation and its timely resolution are critical to ensure effective host defense and appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation typifies many prevalent pathologies. The key mediators that i...