Introduction to the Theme "Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment" [0.03%]
“药理学个体化的新见解与精准用药策略”专栏介绍
Urs A Meyer,Susan G Amara,Terrence F Blaschke et al.
Urs A Meyer et al.
The reviews in Volume 64 of the Annual Review of Pharmacology and Toxicology cover diverse topics. A common theme in many of the reviews is the interindividual variability in the clinical response to drugs. Highlighted areas include emergin...
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury [0.03%]
抗癫痫药物作为颅脑损伤后潜在的痴呆预防药物
Laszlo F Locskai,Hadeel Alyenbaawi,W Ted Allison
Laszlo F Locskai
Seizures and other forms of neurovolatility are emerging as druggable prodromal mechanisms that link traumatic brain injury (TBI) to the progression of later dementias. TBI neurotrauma has both acute and long-term impacts on health, and TBI...
Romina B Cejas,Kateryna Petrykey,Yadav Sapkota et al.
Romina B Cejas et al.
Anthracycline-induced cardiotoxicity (AIC) is a serious and common side effect of anthracycline therapy. Identification of genes and genetic variants associated with AIC risk has clinical potential as a cardiotoxicity predictive tool and to...
Daniel W Nebert
Daniel W Nebert
I am deeply honored to be invited to write this scientific autobiography. As a physician-scientist, pediatrician, molecular biologist, and geneticist, I have authored/coauthored more than 600 publications in the fields of clinical medicine,...
Renske H Olie,Kristien Winckers,Bianca Rocca et al.
Renske H Olie et al.
Direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists, mostly warfarin, for the main indications for oral anticoagulation, prevention and treatment of venous thromboembolism, and prevention of embolic stroke in atri...
Catrin Hasselgren,Tudor I Oprea
Catrin Hasselgren
Drug discovery is adapting to novel technologies such as data science, informatics, and artificial intelligence (AI) to accelerate effective treatment development while reducing costs and animal experiments. AI is transforming drug discover...
Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine [0.03%]
基于质谱的蛋白质基因组学：精准医学的新治疗机会
Sunil K Joshi,Paul Piehowski,Tao Liu et al.
Sunil K Joshi et al.
Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with...
Ekaterini Tiligada,Daria Gafarov,Maria Zaimi et al.
Ekaterini Tiligada et al.
The exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments....
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution [0.03%]
具有单细胞和空间分辨率的药物作用靶点和机制的破译
Zhengyuan Pang,Benjamin F Cravatt,Li Ye
Zhengyuan Pang
Recent advances in chemical, molecular, and genetic approaches have provided us with an unprecedented capacity to identify drug-target interactions across the whole proteome and genome. Meanwhile, rapid developments of single-cell and spati...
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy [0.03%]
药物反应的昼夜调节：迈向性别特异性和个性化时间治疗学
Francis A Lévi,Alper Okyar,Eva Hadadi et al.
Francis A Lévi et al.
Today's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy ...