The expression and function of organic anion transporting polypeptides in normal tissues and in cancer [0.03%]
有机阴离子转运多肽在正常组织和肿瘤中的表达与功能
Amanda Obaidat,Megan Roth,Bruno Hagenbuch
Amanda Obaidat
Organic anion transporting polypeptides (OATPs) are members of the SLCO gene superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies on the basis of their amino acid sequence similarities. OATPs are expres...
Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control [0.03%]
慢性疼痛：药理学策略恢复减弱的抑制性脊髓痛觉控制机制
Hanns Ulrich Zeilhofer,Dietmar Benke,Gonzalo E Yevenes
Hanns Ulrich Zeilhofer
Potentially noxious stimuli are sensed by specialized nerve cells named nociceptors, which convey nociceptive signals from peripheral tissues to the central nervous system. The spinal dorsal horn and the trigeminal nucleus serve as first re...
Adaptive trial designs [0.03%]
自适应试验设计
Tze Leung Lai,Philip William Lavori,Mei-Chiung Shih
Tze Leung Lai
We review adaptive designs for clinical trials, giving special attention to the control of the Type I error in late-phase confirmatory trials, when the trial planner wishes to adjust the final sample size of the study in response to an unbl...
Jawed Fareed,Indermohan Thethi,Debra Hoppensteadt
Jawed Fareed
Since the discovery of heparin nearly a century ago, there have been large gaps in the development of anticoagulants. The discovery of warfarin was the first step toward using oral anticoagulants, but warfarin use has been associated with i...
Caroline H Johnson,Andrew D Patterson,Jeffrey R Idle et al.
Caroline H Johnson et al.
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of whi...
Feng Cong,Atwood K Cheung,Shih-Min A Huang
Feng Cong
Identification of novel, validated targets remains a top priority in modern drug discovery. Chemical genetics represents a powerful approach to the discovery of new targets. Unlike the traditional target-based screen that relies on a predef...
Using genome-wide association studies to identify genes important in serious adverse drug reactions [0.03%]
利用全基因组关联研究识别严重不良药物反应相关的重要基因
Ann K Daly
Ann K Daly
Genome-wide association (GWA) studies have detected novel associations for serious, idiosyncratic, adverse drug reactions including liver toxicity, hypersensitivity, skin rash, and myotoxicity. Human leukocyte antigen (HLA) genotype has bee...
Alfred G Gilman
Alfred G Gilman
The intent is to tell a story-hopefully one that is at various times serious, light-hearted, or provocative-that describes my life in biomedical science, especially focusing on the 50 years from 1961 (as a college senior) to the present.
Shailesh K Choudhary,David M Margolis
Shailesh K Choudhary
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral latency established within the host genome remains lar...
Ling Li,Peter Rose,Philip K Moore
Ling Li
Hydrogen sulfide (H₂S) is a gaseous mediator synthesized from cysteine by cystathionine γ lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments using H₂S donors and genetic experiments using CSE knockout mice sug...