Randall T Peterson,Calum A Macrae
Randall T Peterson
As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a complement to ex...
Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood [0.03%]
围产期环境暴露影响乳腺发育、功能和成人期癌症风险
Suzanne E Fenton,Casey Reed,Retha R Newbold
Suzanne E Fenton
Puberty is an important transition that enables reproduction of mammalian species. Precocious puberty, specifically early thelarche (the appearance of breast "buds"), in girls of multiple ethnic backgrounds is a major health problem in the ...
Nora D Volkow,Gene-Jack Wang,Joanna S Fowler et al.
Nora D Volkow et al.
A major challenge in understanding substance-use disorders lies in uncovering why some individuals become addicted when exposed to drugs, whereas others do not. Although genetic, developmental, and environmental factors are recognized as ma...
Yoshito Kumagai,Yasuhiro Shinkai,Takashi Miura et al.
Yoshito Kumagai et al.
Quinones are a group of highly reactive organic chemical species that interact with biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to induce toxicities. This review describes the chemistry, biochem...
M K DeGorter,C Q Xia,J J Yang et al.
M K DeGorter et al.
Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter fu...
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors [0.03%]
偏向性激活七次跨膜受体的分子机制
Eric Reiter,Seungkirl Ahn,Arun K Shukla et al.
Eric Reiter et al.
The concept of biased agonism has recently come to the fore with the realization that seven-transmembrane receptors (7TMRs, also known as G protein-coupled receptors, or GPCRs) activate complex signaling networks and can adopt multiple acti...
Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories [0.03%]
药物治疗的依从性：关于处方与实际用药剂量之间不可靠联系的研究见解
Terrence F Blaschke,Lars Osterberg,Bernard Vrijens et al.
Terrence F Blaschke et al.
Satisfactory adherence to aptly prescribed medications is essential for good outcomes of patient care and reliable evaluation of competing modes of drug treatment. The measure of satisfactory adherence is a dosing history that includes time...
Timothy A McKinsey
Timothy A McKinsey
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. Two pharmacological inhibitors of protein deacetylation are currently approved for the treatment of human cancer, and...
The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors [0.03%]
GPCRs 的双部位激动剂/别构调节剂：两者兼得？
Celine Valant,J Robert Lane,Patrick M Sexton et al.
Celine Valant et al.
It is now acknowledged that G protein-coupled receptors, the largest class of drug targets, adopt multiple active states that can be preferentially stabilized by orthosteric ligands or allosteric modulators, thus giving rise to the phenomen...
Toshio Tanaka,Masashi Narazaki,Tadamitsu Kishimoto
Toshio Tanaka
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and i...