G Protein-Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders [0.03%]
大脑中的G蛋白偶联受体异源二聚体在神经精神疾病的功能和治疗作用中的重要性
Yalin Sun,Ahmed Hasbi,Susan R George
Yalin Sun
G protein-coupled receptors (GPCRs) represent the largest family of plasma membrane proteins targeted for therapeutic development. For decades, GPCRs were investigated as monomeric entities during analysis of their pharmacology or signaling...
Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field [0.03%]
药物基因组学：所有人的研究计划及其他大型数据集推动该领域发展的机遇
Philip E Empey,Jason H Karnes,Julie A Johnson
Philip E Empey
Pharmacogenetic variation is common and an established driver of response for many drugs. There has been tremendous progress in pharmacogenetics knowledge over the last 30 years and in clinical implementation of that knowledge over the last...
Decoding the Therapeutic Target SVEP1: Harnessing Molecular Trait GWASs to Unravel Mechanisms of Human Disease [0.03%]
解锁治疗靶点SVEP1：利用分子性状GWAS来解析人类疾病机制
Jared S Elenbaas,Paul C Lee,Ved Patel et al.
Jared S Elenbaas et al.
Although human genetics has substantial potential to illuminate novel disease pathways and facilitate drug development, identifying causal variants and deciphering their mechanisms remain challenging. We believe these challenges can be addr...
Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms [0.03%]
脑内甲苯毒性：从细胞靶点到分子机制
Andrew A Shaw,Jeffery D Steketee,Anna N Bukiya et al.
Andrew A Shaw et al.
Toluene intoxication constitutes a persistent public health problem worldwide. While most organs can be damaged, the brain is a primary target whether exposure is accidental, occupational, or recreational. Interventions to prevent/revert br...
Paul McGonigle
Paul McGonigle
Advances in molecular biology and molecular genetics as well as major scientific breakthroughs in immunology and oncology have led to the rapid growth of biologic therapeutics. Their success has resulted in significant changes to virtually ...
Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics [0.03%]
物质使用障碍中的神经可塑性靶向治疗意义研究
Marina E Wolf
Marina E Wolf
The last two decades have witnessed substantial advances in identifying synaptic plasticity responsible for behavioral changes in animal models of substance use disorder. We have learned the most about cocaine-induced plasticity in the nucl...
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases [0.03%]
抑制心律失常性心脏病中细胞内RyR2钙释放通道的治疗药物
Tri Q Do,Björn C Knollmann
Tri Q Do
Ryanodine receptor type 2 (RyR2) is the principal intracellular calcium release channel in the cardiac sarcoplasmic reticulum (SR). Pathological RyR2 hyperactivity generates arrhythmia risk in genetic and structural heart diseases. RYR2 gai...
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review [0.03%]
精准开发非抗癌药物的基因 enrichment 临床试验：一项范围审查
Benoît Delabays,Chiara De Paoli,Andrea Miller-Nesbitt et al.
Benoît Delabays et al.
Genetically driven clinical trial enrichment has been proposed to accelerate and reduce the cost of developing new therapeutics. Usage of this approach has not been comprehensively reviewed. We searched Ovid MEDLINE, Embase, Web of Science,...
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation [0.03%]
药物基因分型检测：当前实践及临床应用潜力综述
R Mosch,M van der Lee,H J Guchelaar et al.
R Mosch et al.
Pharmacogenetics (PGx) aims to optimize drug treatment outcomes by using a patient's genetic profile for individualized drug and dose selection. Currently, reactive and pretherapeutic single-gene PGx tests are increasingly applied in clinic...
Ariana M Chao,Simeon Taylor,Molly Moore et al.
Ariana M Chao et al.
Obesity is a global health concern. Progress in understanding the physiology of obesity and weight reduction has provided new drug targets. Development and testing of new antiobesity medications (AOMs) has the potential to quickly expand op...