Daniel Wacker,John D McCorvy
Daniel Wacker
Psychedelics show tremendous promise for treating psychiatric disorders and other illnesses, including pain and migraine. Despite decades of research, there is uncertainty which signaling mechanisms are necessary for rapid-acting and durabl...
Arthur K Cho,Yoshito Kumagai,Yumi Abiko
Arthur K Cho
Many of the adverse effects of ambient air pollution have been attributed to reactions of chemical species generated from fossil or biogenic fuel combustion. This review focuses on two reactions: (a) a prooxidant reaction, in which oxygen i...
Bruno Spire,Marion di Ciaccio
Bruno Spire
Although HIV treatment and prevention efforts in recent decades have significantly reduced new infections and mortality worldwide, progress has been uneven. Regions with the highest prevalence are those where HIV control programs fail to re...
Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization [0.03%]
细胞纳米颗粒的生物中和的药理机制
Lei Sun,Kailin Feng,Jiayuan Alex Zhang et al.
Lei Sun et al.
Biological neutralization refers to the process by which a biological agent, such as an antibody, enzyme, or therapeutic nanoparticle, renders a target molecule or pathogen harmless or inactive. Traditional approaches, such as antibody-base...
Alexander M Lewis,Kenyon Weis,Omar Abdel-Wahab
Alexander M Lewis
RNA splicing is a nuclear enzymatic process that catalyzes excision of segments of premature messenger RNA (mRNA) and ligation to give rise to mature coding mRNA. Genomic and transcriptomic studies of cancer have revealed that RNA splicing ...
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures [0.03%]
金属和类金属诱导肾毒性的常见不良结局路径以推进化学品混合物下一代风险评估
Tessa Schillemans,Annick D van den Brand,Agneta Åkesson et al.
Tessa Schillemans et al.
Chronic exposure to the metal(loid)s arsenic, cadmium, lead, and mercury via contaminated food or drinking water may induce kidney toxicity, but there is little consensus on the biological processes involved. Health risk assessment of these...
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation [0.03%]
瞬时受体电位香草素亚型1通道的人类突变及其对伤害性冷觉的意义
Ben Katz,Rita Gutorov,Channa Maayan et al.
Ben Katz et al.
Sensing specific temperature ranges as noxious is crucial for protecting organisms from tissue damage. While the molecular detectors for noxious heat are well-characterized, those responsible for noxious cold detection remain elusive. The t...
Lessons from Glucocorticoids, Metformin, and Dimethyl Fumarate: Could Targeting Immunometabolism Lead to Better Anti-Inflammatory Therapies? [0.03%]
从糖皮质激素、二甲双胍及富马酸丁酯的启示：针对免疫代谢通路能否带来更好的抗炎药物？
Victoria A Evans,Luke A J O&#x;Neill
Victoria A Evans
Emerging evidence suggests that alterations in immunometabolism contribute to pathogenesis of inflammatory diseases, providing potential therapeutic targets. Anti-inflammatory drugs such as glucocorticoids, metformin, and dimethyl fumarate ...
Katelynn E Krick,Donna M Wilcock
Katelynn E Krick
Alzheimer's disease (AD) is a complex neurodegenerative disease that leads to cognitive decline and dementia. Over the past two decades, many scientists have contributed to the discovery of therapeutics that target amyloid-beta (Aβ) to slo...
Céline Deraison,Nathalie Vergnolle
Céline Deraison
Chronic inflammation is a common trait in the pathogenesis of several diseases of the gut, including inflammatory bowel disease and celiac disease. Control of the inflammatory response is crucial in these pathologies to avoid tissue destruc...