Olivia Hoffman,Nicholas H Varvel,Avtar S Roopra et al.
Olivia Hoffman et al.
We explore three emerging molecular pathways driving neuroinflammation in chronic and acute brain diseases: the EP2 receptor for prostaglandin E2, the CCR2 receptor for chemokine CCL2, and JAK/STAT signaling. Inflammation is now recognized ...
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases [0.03%]
长效治疗药物在传染病防治中的前景与展望
Adeniyi Olagunju,Simone Perazzolo,Zachary R Stephen et al.
Adeniyi Olagunju et al.
Long-acting (LA) therapeutics have emerged as a key component of infectious disease treatment and prevention strategies, their uptake fueled by the need to bridge notable gaps with short-acting drug formulations. In this review, we present ...
Lisa Stoll,Elizabeth E Ha,James C Lo
Lisa Stoll
Atrial fibrillation (AF) is a common arrhythmia with a tremendous impact on quality of life and mortality. Its prevalence continues to rise alongside the increasing obesity and type 2 diabetes epidemics, raising a need for improved therapeu...
Shane C Wright,Peter Lindquist,Mette M Rosenkilde et al.
Shane C Wright et al.
In light of the success of blockbuster drugs for type 2 diabetes and obesity based on the GLP-1 hormone, drugmakers have concentrated their efforts on developing new and improved variations that address the route of administration, dosing, ...
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging [0.03%]
基于单分子活细胞影像的药物发现方向的可能性
Hideaki Yoshimura,Takeaki Ozawa
Hideaki Yoshimura
In conventional drug discovery, particularly for small molecules, investigating a small compound that matches the structure of the target molecule and alters its activity has been a crucial process. On the other hand, artificially regulatin...
Sana Qayum,Darlaine Pétrin,Jason C Tanny et al.
Sana Qayum et al.
The eponymous term Gβγ protein has given way to a more nuanced view of 60 different possible combinations of the 5 Gβ and 12 Gγ subunits and their effects on cellular signaling profiles. Beyond this increased appreciation of their diver...
Structural Insights into the Development of Inhibitors Against Cancer-Specific Mutations of PI3Kα [0.03%]
PI3Kα癌症特异性突变抑制剂开发的结构洞察
Xiao Liu,Yanyan Chen,Wei Han et al.
Xiao Liu et al.
Phosphoinositide 3-kinase alpha (PI3Kα) is a pivotal regulator of cell growth, proliferation, and survival. Dysregulation of the PI3K/AKT/mTOR pathway, driven predominantly by PIK3CA mutations (e.g., H1047R, E542K, and E545K), is a hallmar...
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe [0.03%]
关于电子烟多系统毒性的临床前和临床研究：从头到脚的电子烟气溶胶暴露的病理生理效应
Matthew J Mears,Priya Bandaru,Evan W Neczypor et al.
Matthew J Mears et al.
The global population breathes unsafe levels of pollutants. In recent years, electronic cigarettes (e-cigs) have become a significant source of particulate matter (PM), which causes injurious effects across organ systems. E-cig users and by...
Alan L Rothman,Heather Friberg
Alan L Rothman
Development of vaccines against dengue has been designated a priority for over 75 years. The completion of Phase III trials and licensing of multiple dengue vaccines have been significant accomplishments of the last 15 years. Despite that p...
Ana M Soto
Ana M Soto
When I was young and pictured my future, it wasn't a path that could be determined a priori. The world was full of interesting things. Obtaining the qualifications to become a professor and a researcher was the easy part. The rest relied on...