Caenorhabditis elegans as a Model System for Environmental Mitotoxicants [0.03%]
好氧线虫作为环境毒理模型生物的研究进展及其应用前景
Akinleye Akinrinde,Luis Andres Sanchez,Silvia Maglioni et al.
Akinleye Akinrinde et al.
Environmental pollutants such as heavy metals, pesticides, and plastic nanoparticles pose significant risks to human, animal, and environmental health. New approach methodologies complying with the 3R principles (replace, reduce, refine) ar...
Introduction to the Theme "New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology" [0.03%]
“推动药理学与毒理学发展的新思路、技术与方法”专栏序言
Paul A Insel,Amrita Ahluwalia,Susan G Amara
Paul A Insel
Volume 66 of the Annual Review of Pharmacology and Toxicology includes numerous articles that reveal evolving ideas and insights in pharmacology and toxicology. The major theme is new approaches, technology and techniques. New ideas include...
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus [0.03%]
美国食品药品监督管理局批准的药物对抗抗菌素抗性的重新定位的机制框架：金黄色葡萄球菌案例研究
Daniel Sun,Victor Nizet
Daniel Sun
The global rise of antibiotic-resistant bacteria poses a critical threat to healthcare systems, challenging researchers to stay ahead of evolving pathogens. Among the most concerning are invasive infections caused by Staphylococcus aureus (...
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology [0.03%]
人工智能时代的早期健康到疾病转化检测对药理学和毒理学的影响
Noa Rappaport,Bartek Nogal,Kevin Perrott et al.
Noa Rappaport et al.
Precision medicine demands a shift from static, single-analyte diagnostics toward dynamic, systems-level understanding of health and disease. This review explores how the convergence of systems biology, multiomics, and artificial intelligen...
Koning Shen,Jenni Durieux,Andrew Dillin
Koning Shen
Growing evidence points to mitochondria as not just the "powerhouse of the cell" but as a major cellular hub for signaling. Mitochondria use signaling pathways to communicate with other organelles within the cell or organs within an organis...
Enhancing Large-Scale Pharmacogenetic Studies in African Populations for Clinical Care and Drug Development [0.03%]
增强非洲人群的大规模药物基因组学研究以促进临床护理和新药开发
Abdoulaye Yalcouyé,Kevin Esoh,Ambroise Wonkam
Abdoulaye Yalcouyé
African populations remain largely underrepresented in genomic studies despite their high genetic diversity. The significant variability in drug efficacy and toxicity across different ancestry populations should trigger more diversified and...
From Cell Reprogramming to Tissue Rejuvenation: Countering Aging by Targeting a Gerozyme [0.03%]
从细胞重编程到组织年轻化：通过靶向衰老酶对抗衰老
Helen M Blau,Ermelinda Porpiglia
Helen M Blau
Here I highlight personal and professional experiences that shaped my career and defined my scientific journey, with my longtime colleague, Ermelinda Porpiglia. I hope that sharing my life's adventures will inspire others to enjoy both a fu...
Olivia Hoffman,Nicholas H Varvel,Avtar S Roopra et al.
Olivia Hoffman et al.
We explore three emerging molecular pathways driving neuroinflammation in chronic and acute brain diseases: the EP2 receptor for prostaglandin E2, the CCR2 receptor for chemokine CCL2, and JAK/STAT signaling. Inflammation is now recognized ...
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases [0.03%]
长效治疗药物在传染病防治中的前景与展望
Adeniyi Olagunju,Simone Perazzolo,Zachary R Stephen et al.
Adeniyi Olagunju et al.
Long-acting (LA) therapeutics have emerged as a key component of infectious disease treatment and prevention strategies, their uptake fueled by the need to bridge notable gaps with short-acting drug formulations. In this review, we present ...
Lisa Stoll,Elizabeth E Ha,James C Lo
Lisa Stoll
Atrial fibrillation (AF) is a common arrhythmia with a tremendous impact on quality of life and mortality. Its prevalence continues to rise alongside the increasing obesity and type 2 diabetes epidemics, raising a need for improved therapeu...