Multidisciplinary research agenda for novel antimicrobial agents for caries prevention and treatment [0.03%]
龋病预防和治疗新型抗菌剂的多学科研究议程
M Maltz,D Beighton
M Maltz
Antimicrobial methods to augment fluoride-mediated caries inhibition are necessary. Several methods are described here, but none was considered likely to be as effective as fluoride usage. None had been tested in effective models to demonst...
Remineralization models [0.03%]
再矿化模型
N J Cochrane,D T Zero,E C Reynolds
N J Cochrane
During the ICNARA 2 conference, a workshop was held on remineralization models. The group considered the role of remineralization models, whether there was one ideal in situ model design, what essential features should be incorporated into ...
Are we ready for definitive clinical guidelines on xylitol/polyol use? [0.03%]
我们已经为明确的关于木糖醇/糖醇使用的临床指南做好准备了吗？
M Fontana,C González-Cabezas
M Fontana
In the past decades, numerous studies have looked at the anticaries effects of polyols, particularly xylitol, and a great many studies have focused on xylitol's antimicrobial properties. Researched vehicles have mostly included chewing gums...
Clinical efficacy and effects of xylitol wipes on bacterial virulence [0.03%]
木糖醇消毒湿巾的临床效果及对细菌毒力的影响研究
L Zhan,J D B Featherstone,J Lo et al.
L Zhan et al.
The aim of the study was to investigate whether xylitol-wipe use in young children prevented caries by affecting bacterial virulence. In a double-blinded randomized controlled clinical trial, 44 mother-child pairs were randomized to xylitol...
Randomized Controlled Trial
Advances in dental research. 2012 Sep;24(2):117-22. DOI:10.1177/0022034512449835 2012
P Milgrom,E M Söderling,S Nelson et al.
P Milgrom et al.
Xylitol is a safe dental caries preventive when incorporated into chewing gum or confections used habitually. The goal of this paper is to identify and assess the work on xylitol and other polyols and dental caries since 2008. Xylitol is ef...
The numerous microbial species in oral biofilms: how could antibacterial therapy be effective? [0.03%]
牙菌斑中的多种微生物：抗菌治疗如何才能有效？
J M ten Cate,E Zaura
J M ten Cate
Hundreds of bacterial species inhabit the oral cavity. Many of these have never been cultivated and can be assessed only with DNA-based techniques. This new understanding has changed the paradigm of the etiology of oral disease from that as...
O Feuerstein
O Feuerstein
Conventional antibacterial treatment fails to eradicate biofilms associated with common infections of the oral cavity. Unlike chemical agents, which are less effective than anticipated, owing to diffusion limitations in biofilms, light is m...
S Twetman,M K Keller
S Twetman
Modulation of the microbiota for restoring and maintaining health is a growing issue in medical science. A search for relevant clinical trials on the use of probiotic bacteria as a potential and clinically applicable anti-caries measure was...
Targeted antimicrobial treatment to re-establish a healthy microbial flora for long-term protection [0.03%]
靶向抗菌疗法重建有益微生物群实现长期保护
R Eckert,R Sullivan,W Shi
R Eckert
Streptococcus mutans has been implicated as the major acid-producing (cariogenic) bacterium. Dietary sugars and other factors may cause an imbalance of oral microflora that enables S. mutans to become dominant in the multi-species biofilms ...
Strategic protein target analysis for developing drugs to stop dental caries [0.03%]
靶向蛋白质战略分析以研发阻止龋齿的药物
J A Horst,U Pieper,A Sali et al.
J A Horst et al.
Dental caries is the most common disease to cause irreversible damage in humans. Several therapeutic agents are available to treat or prevent dental caries, but none besides fluoride has significantly influenced the disease burden globally....