Decorin inhibits the migration and invasion of the LPS + high glucose-induced primary trophoblast cell through ADAMTS12 [0.03%]
decorin通过ADAMTS12抑制LPS联合高糖诱导的原代滋养细胞迁移和侵袭作用
Qiuling Chen,Taoyan Hu,Hui Luo
Qiuling Chen
Decorin was identified as the most relevant biomarker in type 2 diabetes or obesity-related diseases, but its function in gestational obesity or gestational diabetes mellitus (GDM) remains unknown. RT-qPCR or western blot were employed to v...
Xiaolong Yu,Qing Chang,Lina Wang
Xiaolong Yu
To develop a biological pacemaker by differentiating rabbit BMSCs into vascular endothelial cells (VECs) and pacemaker-like cells, and constructing a 3D vascularized sinoatrial node (SAN) in vitro. BMSCs were isolated via whole bone marrow ...
miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression [0.03%]
miR-495-3p通过靶向CCL2表达来缓解脑缺血再灌注诱导的神经炎症和细胞凋亡
XiaoDong Yu,LiZhi Xue,WenQin Zou et al.
XiaoDong Yu et al.
This study aimed to explore the function of miR-495-3p in cerebral ischemia-reperfusion injury (CI/RI) and reveal its potential molecular mechanism. In vivo and in vitro models of CI/RI were established by MACO/R and OGD/R, respectively. Ne...
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling [0.03%]
壳聚糖-胶原水溶性灯盏花素膜通过抑制Wnt/β-catenin信号通路缓解椎间盘退变
Zhaozhong Yu,Jun Kuang,Xuan Wan et al.
Zhaozhong Yu et al.
Intervertebral disc degeneration (IVDD), a natural aging process, leads to intervertebral disc pain, with lumbar resection providing pain relief but potential postoperative complications affecting outcomes. The chitosan-collagen-salvianolic...
Comparative pathophysiological modeling: the advantage of "two-hit" over "one-hit" in acute liver failure studies [0.03%]
急性肝脏衰竭研究中“双事件”优于“单事件”的病理生理学模型比较优势分析
Yishu Yan,Jingping Huang,Mingzhu Chen et al.
Yishu Yan et al.
Acute liver failure (ALF), a life-threatening condition marked by rapid hepatocyte death and systemic inflammation, poses significant clinical challenges due to its high mortality. The crosstalk between necrotic hepatocytes and infiltrating...
A preliminary study on the mechanism of stromal interaction molecule 1 (STIM1) involvement in Adriamycin-induced podocyte injury [0.03%]
STIM1介导阿霉素损伤足细胞的初步研究机制探讨
Li Miao,Mi Bai,Songming Huang et al.
Li Miao et al.
Cellular metabolic reprogramming is intimately linked to various physiological and pathological processes. For instance, calcium (Ca2⁺)-mediated signaling pathways are essential for maintaining the homeostasis of critical cellular organell...
Mechanisms of Xinwei Tang in stress-induced gastric dysmotility: evidence from rat and In Vitro models [0.03%]
新胃灵颗粒抗应激性胃肠动力障碍的机制研究：大鼠及细胞模型证据
Man Tian,Honghui Xiao,Yingbing Mei et al.
Man Tian et al.
Stress is a key trigger of gastric dysmotility, partly via mitochondrial dysfunction and disordered gut-brain hormonal signaling. Xinwei Tang (XWT) is a multi-herb formula used empirically for upper gastrointestinal symptoms, but its mechan...
VEGFA is essential for the potentiation of ATRA on BMP9-induced osteogenesis of preadipocytes and osteoporotic fracture healing [0.03%]
VEGFA对于ATRA促进前脂肪细胞和骨质疏松性骨折愈合中的BMP9诱导成骨作用的增强是必不可少的
Hao Wang,Jingjiang Wang,Jiangyu Xiang et al.
Hao Wang et al.
The induction of osteogenic differentiation in preadipocytes may serve as a potential therapeutic approach for treating osteoporosis and osteoporotic fractures. All-trans retinoic acid (ATRA) promotes the bone morphogenetic protein 9 (BMP9)...
The differential expression of lipocalin-2 in pig tissues and its molecular mechanism of regulating cell viability, differentiation, adipogenesis, and glycometabolism in porcine intramuscular preadipocytes [0.03%]
脂联素-2在猪组织中的差异表达及其调控肌间前脂肪细胞存活、分化、脂肪生成和糖代谢的分子机制研究
Xiaoying Dong,Yanfei Chen,Liubing Tang et al.
Xiaoying Dong et al.
Lipocalin-2 (LCN-2) is an adipocytokine secreted mainly by adipose tissue. Increasing evidences suggest that LCN-2 is an inflammatory factor associated with insulin resistance, obesity, and its complications. The precise mechanism of the de...
Network pharmacology analysis and experimental validation of modified Taohong Siwu decoction against atherosclerosis [0.03%]
基于网络药理学的调息解郁颗粒化瘀通络功效物质基础研究及实验验证
Changle Shao,Wanting Meng,Ke Ning et al.
Changle Shao et al.
The modified Taohong Siwu decoction (MTHSWD), a traditional prescription, demonstrates notable efficacy in treating cardiovascular diseases. However, its potential mechanisms in addressing atherosclerosis (AS) require further exploration. I...