JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment [0.03%]
JAML通过调节肿瘤免疫微环境抑制结直肠癌发生发展
Shiliang Cheng,Meng Li,Chunguang Li et al.
Shiliang Cheng et al.
It is necessary to explore new targets for the treatment of colon adenocarcinoma (COAD) according to the tumor microenvironment. The expression levels of JAML and CXADR were analyzed by bioinformatics analysis and validation of clinical sam...
Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells [0.03%]
反凋亡蛋白Bcl-2参与肌源性分化过程中C2C12卫星储备细胞的决定效应
Yosuke Nagata,Jun Tomimori,Tomoharu Hagiwara
Yosuke Nagata
Skeletal muscle's regenerative ability is vital for maintaining muscle function, but chronic diseases like Duchenne muscular dystrophy can deplete this capacity. Muscle satellite cells, quiescent in normal situations, are activated during m...
3,3'-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice [0.03%]
3,3'-二吲哚甲烷通过损害成纤维细胞活化的树突状细胞诱导的干扰素调节因子-7介导的浆细胞样树突状细胞活化来抑制Th17细胞分化以治疗咪喹莫特诱导的小鼠银屑病
Mahaboobkhan Rasool,Manupati Srikanth,Arulkumaran Rithvik
Mahaboobkhan Rasool
Psoriasis is a paradigmatic condition characterised by a heightened autoimmune response and chronic inflammation. However, the exact nature and the pathological causes behind it are still unknown. Growing evidence suggest dysregulated cytok...
Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study [0.03%]
抑制炎症和氧化应激并诱导细胞凋亡的鸟取素抗肺癌保护作用的体内外研究
Zhiguo Dang,Songbo Liu,XiaoJuan Wang et al.
Zhiguo Dang et al.
The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was invest...
High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy [0.03%]
携带抗CD22嵌合抗原受体的自然杀伤细胞治疗高效诱导淋巴瘤细胞死亡
Mahnoosh Abbaszade Dibavar,Masoud Soleimani,Mohammad Hossein Mohammadi et al.
Mahnoosh Abbaszade Dibavar et al.
Chimeric antigen receptors (CARs) offer a promising new approach for targeting B cell malignancies through the immune system. Despite the proven effectiveness of CAR T cells targeting CD19 and CD22 in hematological malignancies, it is imper...
A comparative study on targeted gene expression in zebrafish and its gill cell line exposed to chlorpyrifos [0.03%]
毒死蜱暴露下斑马鱼及其鳃细胞系靶基因表达的比较研究
Abdul Wazith M J,Taju G,Abdul Majeed S et al.
Abdul Wazith M J et al.
Chlorpyrifos (CPF) is an organophosphorus-based insecticide, which is known to pose a serious risk to aquatic animals. However, the mechanisms of CPF toxicity in animals still remain unclear. The present investigation aimed to compare the p...
Rutin alleviates Sjogren's syndrome via CaR/NLRP3/NF-κB signal pathway [0.03%]
rutin通过CaR/NLRP3/NF-κB信号途径缓解Sjögren综合征
Jing He,Meimei Xu,Suling Wu
Jing He
Sjogren's syndrome (SS) is an autoimmune disease. Its mechanism and treatment methods are unclear. The purpose of this study was to investigate the effects of rutin (Ru) on SS. Proteomics was used to detect differential proteins in the subm...
Koki Kamizaki,Yasuhiro Minami,Michiru Nishita
Koki Kamizaki
Ror-family receptors, Ror1 and Ror2, are type I transmembrane proteins that possess an extracellular cysteine-rich domain, which is conserved throughout the Frizzled-family receptors and is a binding site for Wnt ligands. Both Ror1 and Ror2...
Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK [0.03%]
circ_0073932通过miR-493-3p/FAF1/JNK抑制心肌缺血再灌注损伤
Yang Su,Lili Zhao,Dongli Lei et al.
Yang Su et al.
Oxidative stress and apoptosis play crucial roles in myocardial ischemia‒reperfusion injury (MIRI). In this study, we investigated the role of circ_0073932 in MIRI as well as its molecular mechanism. A hypoxia/reoxygenation (H/R) cardiomyo...
Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3 [0.03%]
维生素D3可通过 pentraxin 3 抑制颗粒细胞血管生成因子的释放从而缓解小鼠卵巢过度刺激综合征症状
Minping Zhang,Li Chen,Qunping Xu et al.
Minping Zhang et al.
It has been reported that the effective inhibition of vascular endothelial growth factor (VEGF) can prevent the progression of ovarian hyperstimulation syndrome (OHSS). The present study aimed to investigate the mechanism underlying the eff...