Characteristics of nuclear architectural abnormalities of myotubes differentiated from LmnaH222P/H222P skeletal muscle cells [0.03%]
LmnaH222P/H222P骨骼肌细胞分化出来的肌管核结构异常的特征分析
Eiji Wada,Nao Susumu,Motoshi Kaya et al.
Eiji Wada et al.
The presence of nuclear architectural abnormalities is a hallmark of the nuclear envelopathies, which are a group of diseases caused by mutations in genes encoding nuclear envelope proteins. Mutations in the lamin A/C gene cause several dis...
Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol [0.03%]
维生素D或艾地司珠醇通过作用于角化鳞状细胞癌的硫酸肝素结合蛋白17/成纤维细胞生长因子结合蛋白1的潜在治疗机制研究
Tomoaki Shintani,Mirai Higaki,Siti Nur Zawani Rosli et al.
Tomoaki Shintani et al.
Heparin-binding protein 17 (HBp17), first purified in 1991 from the conditioned medium of the human A431 squamous cell carcinoma (SCC) cell line, was later renamed fibroblast growth factor-binding protein 1 (FGFBP-1). HBp17/FGFBP-1 is speci...
Keita Horitani,Ichiro Shiojima
Keita Horitani
The Wnt signaling pathway is a fundamental cellular communication system with extensive implications in various organs including the heart. In cardiac homeostasis, it governs essential processes like cellular proliferation, differentiation,...
Differentiation of bone marrow mesenchymal stem cells into Leydig-like cells with testicular extract liquid in vitro [0.03%]
体外睾丸提取液诱导骨髓间充质干细胞向类Leydig细胞分化
Rong Hua,Fang-Fang Liang,Fang-Qiang Gong et al.
Rong Hua et al.
Differentiation of Leydig cells plays a key role in male reproductive function. Bone marrow mesenchymal stem cells (BMSCs) have emerged as a potential cell source for generating Leydig-like cells due to their multipotent differentiation cap...
BMSC-derived exosomes regulate the Treg/Th17 balance through the miR-21-5p/TLR4/MyD88/NF-κB pathway to alleviate dry eye symptoms in mice [0.03%]
人源BMSC衍生的外泌体通过miR-21-5p/TLR4/MyD88/NF-κB信号通路调节Treg/Th17平衡从而缓解小鼠干眼症
Dandan Zhao,Hao Ji,Hongxia Zhao et al.
Dandan Zhao et al.
Bone marrow mesenchymal stem cell (BMSC)-derived exosomes (BMSC-Exos) have a variety of biological functions and are extensively involved in the regulation of inflammatory diseases, as well as tissue repair and regeneration. However, the me...
Taro Osawa,Daisuke Yamada,Tomoko Takao et al.
Taro Osawa et al.
Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in clinical applications for the amelioration of immune disorders, including graft-versus-host disease (GvHD) and Crohn's disease. The immunosuppressive role of Programm...
Evaluation of culture methods and chemical reagent combinations on CRISPR/Cas9 gene editing systems by lipofection in pig zygotes [0.03%]
脂质体转染法评估CRISPR / Cas9基因编辑系统在猪受精卵中的文化方法和化学试剂组合的评估
Qingyi Lin,Koki Takebayashi,Nanaka Torigoe et al.
Qingyi Lin et al.
The delivery of CRISPR/Cas ribonucleoprotein (RNP) complexes is gaining attention owing to its high cleavage efficiency and reduced off-target effects. Although RNPs can be delivered into porcine zygotes via electroporation with relatively ...
The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells [0.03%]
人多能干细胞向中内胚层分化过程中细胞的迁移模式
Kenshiro Maruyama,Shota Miyazaki,Ryo Kobayashi et al.
Kenshiro Maruyama et al.
Gastrulation is the first major differentiation process in animal embryos. However, the dynamics of human gastrulation remain mostly unknown owing to the ethical limitations. We studied the dynamics of the mesoderm and endoderm cell differe...
Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue [0.03%]
从移植的大鼠肠组织中分离出的成年毛囊干细胞向神经元细胞分化
Zuyin Sun,Jiashi Huo,Yongshen Tian et al.
Zuyin Sun et al.
Hair follicle stem cells (HFSCs) are adult stem cells located in the outer root sheath of the follicle bulge with high neural plasticity, which promise a potential for the stem cell therapy for neurological diseases. Hirschsprung's disease ...
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling [0.03%]
肿瘤内皮细胞衍生的Sfrp1通过Wnt信号传导支持癌干细胞的维持
Yumiko Hayashi,Masakazu Hashimoto,Katsuyoshi Takaoka et al.
Yumiko Hayashi et al.
Cancer stem cells (CSCs), which are critical targets for cancer therapy as they are involved in drug resistance to anticancer drugs, and metastasis, are maintained by angiocrine factors produced by particular niches that form within tumor t...