Use of modified human hemangioma tissue cultures and human umbilical vein endothelial cell cultures to gain mechanistic insights into imiquimod treatment for infantile hemangioma [0.03%]
应用改良的人类血管瘤组织培养和人脐静脉内皮细胞培养来深入了解咪喹莫德治疗婴幼儿血管瘤的机制
Abby Meyer,Lindsey Mortensen,Kimberly A Miller et al.
Abby Meyer et al.
Infantile hemangiomas (IH) are a common entity encountered by dermatologists, otolaryngologists, and other surgeons. Oral propranolol is a mainstay of treatment for IH and is well-tolerated, though propranolol-refractory IH and other drug-r...
IL-27 attenuated macrophage injury and inflammation induced by Mycobacterium tuberculosis by activating autophagy [0.03%]
白介素-27通过激活自噬减轻结核分枝杆菌所致巨噬细胞损伤和炎症反应
Yushan Zhou,Yuxuan Zhang,Yanli Li et al.
Yushan Zhou et al.
Interleukin-27 (IL-27) is a cytokine that is reported to be highly expressed in the peripheral blood of patients with pulmonary tuberculosis (PTB). IL-27-mediated signaling pathways, which exhibit anti- Mycobacterium tuberculosis (Mtb) prop...
Optimization of embryonic stage for aggregation to generate chimeric pigs using gene-edited blastomeres [0.03%]
优化胚胎阶段以使用基因编辑的卵裂球生成嵌合猪
Koki Takebayashi,Manita Wittayarat,Maki Hirata et al.
Koki Takebayashi et al.
Jyotsna Jyotsna
Jyotsna Jyotsna
Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells [0.03%]
Astragaloside通过调节TRAF6 / NF-κB途径促进MSC衍生的外泌体miR-146a-5p分泌以减轻高糖损伤的内皮细胞的炎症作用
Jiye Chen,Jiayao Chen,Qinxia Li et al.
Jiye Chen et al.
This study aimed to explore the potential of using mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos) pre-treated with Astragaloside IV (ASIV) to alleviate inflammation in high glucose (HG)-damaged endothelial cells. MSC-Exos were isol...
Pharmacoproteogenomic approach identifies on-target kinase inhibitors for cancer drug repositioning [0.03%]
药理蛋白基因组学方法识别出针对癌症再定位药物的靶向激酶抑制剂
Rei Noguchi,Julia Osaki,Takuya Ono et al.
Rei Noguchi et al.
Drug repositioning of approved drugs offers advantages over de novo drug development for a rare type of cancer. To efficiently identify on-target drugs from clinically successful kinase inhibitors in cancer drug repositioning, drug screenin...
Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation [0.03%]
用于骨再生的预血管化多孔明胶包被β-三磷酸钙支架的体内和体外研究
Hanieh Nokhbatolfoghahaei,Sahar Baniameri,Reza Tabrizi et al.
Hanieh Nokhbatolfoghahaei et al.
Vascularization is vital in bone tissue engineering, supporting development, remodeling, and regeneration. Lack of vascularity leads to cell death, necessitating vascularization strategies. Angiogenesis, forming new blood vessels, provides ...
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy [0.03%]
基于原代细胞水平评价脂肪源性干细胞优于肌肉源性干细胞
Lanlan Bai,Ken Sawai,Tetsuta Tani et al.
Lanlan Bai et al.
Establishment and characterization of novel spontaneously immortalized larval cell lines from sablefish Anoplopoma fimbria [0.03%]
大西洋黑线银鲛仔鱼细胞系的建立及特征分析
Eric R Friesen,Amy K Long,Kyle A Garver
Eric R Friesen
Sablefish Anoplopoma fimbria is a groundfish of the North Pacific Ocean typically found in sea floor habitat at depths to 2700 m. Prized as a food fish with exceptionally high market value, sablefish aquaculture has been sought to provide a...
Study on the mechanism of SAR1B in sodium acetate promoting milk fat synthesis [0.03%]
SAR1B在醋酸钠促乳脂合成机制研究
Zhixia Wang,Haixin Fu,Na Zhang
Zhixia Wang
Acetate can promote milk fat synthesis in dairy cow mammary epithelial cells (BMECs). In this study, gene function analysis was used to explore the role of Ras family secretion-related GTP binding protein 1B (SAR1B) in milk fat synthesis of...