5-Azacytidine inhibits endoplasmic reticulum stress and apoptosis of nucleus pulposus cells by preserving PPARγ via promoter demethylation [0.03%]
5-氮杂胞嘧啶通过促进过氧化物酶体增殖物激活受体gamma的启动子去甲基化抑制内质网应激和细胞凋亡
Peng Cheng,Huan Li,Hai-Wei Chen et al.
Peng Cheng et al.
Low back pain (LBP) is a common symptom of intervertebral disc degeneration (IDD). However, the pathogenesis of IDD is not well understood. Several studies have shown that patients with IDD experience aberrant changes in DNA methylation. 5-...
Cell Painting of insect gut cells for exploration of molecular responses of insect epithelia to insecticides [0.03%]
昆虫肠道细胞的细胞染色技术用于探索上皮细胞对杀虫剂的分子反应
Franziska Annabelle Hecker,Bruno Leggio,Tim Koenig et al.
Franziska Annabelle Hecker et al.
Cell Painting is a sophisticated high-content imaging technique that has been predominantly applied to mammalian cells. Recent advancements have extended its applicability to the first insect cell line, the ovarian cell line Sf9, revealing ...
Resolvin D1 suppresses inflammation in human fibroblast-like synoviocytes via the p-38, NF-κB, and AKT signaling pathways [0.03%]
消解素D1通过p-38、NF-κB和AKT信号通路抑制人成纤维样滑膜细胞炎症反应
Makoto Yanoshita,Naoto Hirose,Sayuri Nishiyama et al.
Makoto Yanoshita et al.
Synovitis represents the initial pathological change in osteoarthritis and contributes to its progression. Resolvin D1 (RV-D1) is a novel and endogenous docosahexaenoic acid-derived lipid mediator, which regulates the duration and magnitude...
Inhibitory effects of carbohydrazide indole derivative on micro-blood vessel growth using ex vivo, in vivo, and in vitro assays [0.03%]
碳水肼吲哚衍生物对微血管生长的抑制作用的体外、体内及离体实验研究
Bayan Jamal Khaleel,Hayder Ridha-Salman,Haitham Mahmood Kadhim et al.
Bayan Jamal Khaleel et al.
Defective angiogenesis is a characteristic of many diseases, notably cancer and immune-mediated conditions. Numerous shortcomings in anti-angiogenic therapies, including undesirable effects, drug resistance, and cancer recurrence, encourage...
Leukemia inhibitory factor promotes growth and maintains stemness in giant panda MSCs [0.03%]
白细胞抑制因子促进大熊猫间充质干细胞的增殖并维持其干性
Feiping Li,Yuliang Liu,Mengshi Zhang et al.
Feiping Li et al.
The effect of IGF-1 on cartilage injury in bone marrow mesenchymal stem cells through the BMP2-Smad1/5 signaling pathway [0.03%]
IGF-1通过BMP2-Smad1/5信号通路对骨髓间充质干细胞软骨损伤的影响
HuiYue Ye,Liang Shao
HuiYue Ye
The objective of this study is to analyze the effect of insulin-like growth factor-1 (IGF-1) in bone marrow mesenchymal stem cells (BMSCs) on cartilage injury and explore the regulatory mechanism of IGF-1 on the bone morphogenetic protein 2...
The combination of neurotropic B vitamins (B1, B6, and B12) is superior to individual B vitamins in promoting neurite growth in vitro [0.03%]
神经趋向性B族维生素(B1、B6和B12)的结合在体外促进神经突生长方面优于单一的B族维生素
Melissa L D Rayner,Arnaud J Ruiz,Christian Viel
Melissa L D Rayner
Compatibility of Calycosin-Tanshinone IIA improves Ang II-induced renal artery endothelial cell dysfunction through lncRNA-mRNA co-expression network [0.03%]
黄酮类和丹参茋类化合物的兼容性通过长链非编码RNA-信使RNA共表达网络改善血管紧张素II诱导的肾动脉内皮细胞功能障碍
YanYun Jiang,Cong Han,WanLi Xu et al.
YanYun Jiang et al.
This study aimed to investigate the effect of the compatibility of Calycosin and Tanshinone IIA on dysfunction of rat renal artery endothelial cells (RRAECs) induced by angiotensin II (Ang II) and to elucidate the underlying molecular mecha...
Atorvastatin inhibits ischemia‒reperfusion-associated renal tubular cell ferroptosis by blocking the PGE2/EP4 signaling pathway [0.03%]
阿托伐他汀通过阻断PGE2/EP4信号通路抑制肾小管上皮细胞缺血再灌注铁死亡
Jing Yang,Rongrong Zhou,Mengjiao Zhou et al.
Jing Yang et al.
Renal ischemia‒reperfusion (I/R) injury is the main cause of acute kidney injury, and its pathological features are manifested primarily by renal tubular epithelial cell injury. The underlying mechanism involves ferroptosis of renal tubula...
Development and characterization of a cell line from the caudal fin of Schizothorax niger (Heckel, 1838) for in vitro toxicity testing [0.03%]
源于齐口裂腹鱼尾鳍的细胞系的发育和表征用于体外毒性试验
Ashaq Sultan Dar,Fayaz Ahmad,Feroz Ahmad Shah et al.
Ashaq Sultan Dar et al.
Here, we successfully grew the SNCF (Schizothorax niger caudal fin) cell line from the caudal fin explants of S. niger, an important cold-water fish of the Himalayas. The cells were successfully grown up to 22 passages by planting explant t...