Michael A Steinman
Michael A Steinman
Mark W Bowie,Patricia W Slattum
Mark W Bowie
Background: Older individuals experience physiologic changes in organ function related to aging or to specific disease processes. These changes can affect drug pharmacodynamics in older adults. ...
Monoclonal antibodies as targeted therapy in hematologic malignancies in older adults [0.03%]
老年血液系统恶性肿瘤靶向治疗中的单克隆抗体疗法
Arati V Rao,Kenneth Schmader
Arati V Rao
Background: Biological agents are proving to be increasingly useful and exciting additions to the antineoplastic armamentarium, but many clinicians are unfamiliar with the properties of these types of agents. ...
Randi Cohen,Kirsten M Wilkins,Robert Ostroff et al.
Randi Cohen et al.
Background: Atypical antipsychotics are commonly used to treat behavioral disturbances in elderly demented patients. However, recent data have brought the tolerability of these drugs into question, as the majority of them...
Methimazole-induced cholestatic jaundice in an elderly hyperthyroid patient [0.03%]
老年甲亢患者服用甲巯咪唑致胆汁淤积性黄疸
Luz S Ramos-Bonner,Todd H Goldberg,Susan Moyer et al.
Luz S Ramos-Bonner et al.
Background: Hyperthyroidism is a common disease in the elderly. Antithyroid medications such as methimazole are one of the few treatment options. Case sum...
Delayed discharges due to initiation of warfarin in atrial fibrillation: a prospective audit [0.03%]
华法林治疗心房颤动延迟出院的回顾性分析
Evelyn S Tan,Tessa J Bonnett,Ahmed H Abdelhafiz
Evelyn S Tan
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Objective: The goal of this study was to determin...
Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients [0.03%]
镇静评分作为重症监护病房患者镇静和止痛药物暴露的指标
Andrew L Masica,Timothy D Girard,Grant R Wilkinson et al.
Andrew L Masica et al.
Background: It is unclear how best to measure sedative/analgesic drug exposure in the clinical care of critically ill patients. Large doses and prolonged use of sedatives and analgesics in the intensive care unit (ICU) ma...
Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication [0.03%]
关于治疗痴呆症行为和心理症状的双丙戊酸钠开放性前瞻性研究单药及与非典型抗精神病药物联用的疗效报告
Brent Forester,Mark Vanelli,Joan Hyde et al.
Brent Forester et al.
Background: Studies of pharmacotherapy for agitation in dementia have primarily been limited to single-drug trials and have not determined if some forms of agitated behaviors are more responsive to treatment than others. ...
Variation in antidiabetic medication intensity among Medicare beneficiaries with diabetes mellitus [0.03%]
医疗保险受益人的抗糖尿病药物强度的差异性分析
Bruce Stuart,Thomas J Shaffer,Linda J Simoni-Wastila et al.
Bruce Stuart et al.
Background: Recent guidelines for treating older patients with diabetes mellitus (DM) and significant disease burden place less emphasis on glycemic control and stress the potential harms that may arise from adherence to ...
Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice [0.03%]
老年人群中不同他汀类药物治疗患者的低密度脂蛋白胆固醇水平及达标情况对比研究
Carolyn R Harley,Sanjay Gandhi,James Blasetto et al.
Carolyn R Harley et al.
Background: Reducing low-density lipoprotein cholesterol (LDL-C) levels lowers the risk of consequences of cardiovascular disease. Research has confirmed these benefits in elderly patients. The 3-hydroxy-3-methylglutaryl ...