Naoya Kobayashi,Jorge David Rivas-Carrillo,Alejandro Soto-Gutierrez et al.
Naoya Kobayashi et al.
Since the establishment of embryonic stem (ES) cells and the identification of tissue-specific stem cells, researchers have made great strides in the analysis of the natural biology of such stem cells for the development of therapeutic appl...
Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies [0.03%]
胚胎植入前的表观遗传重编程及对辅助生殖技术的影响
Christine Wrenzycki,Doris Herrmann,Andrea Lucas-Hahn et al.
Christine Wrenzycki et al.
Knowledge about preimplantation development is important both for basic reproductive biology and for practical applications, including livestock breeding and regenerative medicine. During preimplantation development, epigenetic modification...
Yasuo Ishii,Takashi Mikawa
Yasuo Ishii
The chick embryo is a versatile model system, in which classical embryology can be combined with modern molecular approaches. In the last two decades, several efficient methods have been developed to introduce exogenous genes into the chick...
Embryonic and fetal programming of physiological disorders in adulthood [0.03%]
胚胎和胎儿期的生理状态与成人后的疾病发病状况编程关系研究进展
Christopher Lau,John M Rogers
Christopher Lau
In the past decade, data from numerous epidemiological studies have indicated strong inverse associations between birth weight and risk of coronary heart disease, hypertension, type 2-diabetes, and other diseases in adulthood. The "Barker h...
Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison [0.03%]
孕期早期毒物在胚胎体内分布的调节机制：跨物种对比分析
Edward W Carney,Anthony R Scialli,Rebecca E Watson et al.
Edward W Carney et al.
The dose of toxicant reaching the embryo is a critical determinant of developmental toxicity, and is likely to be a key factor responsible for interspecies variability in response to many test agents. This review compares the mechanisms reg...
Robert M Cabrera,Denise S Hill,Analee J Etheredge et al.
Robert M Cabrera et al.
Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000 births, yet the mechanisms by which they arise are unknown. There have been consistent efforts in many fields of research to elucidate the etiology of t...
Response characteristics of the mitochondrial DNA genome in developmental health and disease [0.03%]
发育与疾病过程中线粒体DNA基因组的响应特征
Thomas B Knudsen,Maia L Green
Thomas B Knudsen
This review focuses on mitochondrial biology in mammalian development; specifically, the dynamics of information transfer from nucleus to mitochondrion in the regulation of mitochondrial DNA genomic expression, and the reverse signaling of ...
Scott F Gilbert
Scott F Gilbert
The environment can play a significant role in the production of phenotypes. However, the developmental mechanisms by which the environment can affect normal development are only now being elucidated. At least three paths have been found th...
Cytotoxicant-induced trophoblast dysfunction and abnormal pregnancy outcomes: role of zinc and metallothionein [0.03%]
细胞毒物质引起的滋养细胞功能障碍及不良妊娠结局：锌和金属硫蛋白的作用
Mary Frances McAleer,Rocky S Tuan
Mary Frances McAleer
Normal trophoblast function, including implantation, hormone production, and formation of the selectively permeable maternofetal barrier, is essential for the establishment and maintenance of the fetoplacental unit and proper fetal developm...
Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture [0.03%]
基于表观荧光图像获取的胚胎快速高分辨率三维重建技术
Julie Rosenthal,Vipul Mangal,Diana Walker et al.
Julie Rosenthal et al.
One of the overarching goals in developmental biology is the elucidation of mechanisms that elaborate form and function. To this end, an accurate morphological description of embryonic development is essential. However, visualizing dynamic ...