The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cords [0.03%]
胎盘和产后睾丸生精小管中的ADAM-整合素-四跨膜蛋白复合体
Laura L Tres,Abraham L Kierszenbaum
Laura L Tres
New insights have emerged about the expression, during testicular cord formation, of the ADAM (a disintegrin and metalloprotease) domain family of proteins that combines both cell surface adhesion and proteolytic activity; this family inclu...
Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction [0.03%]
表观遗传学调控异常与人类疾病和辅助生殖技术的关系研究进展
Philippe Arnaud,Robert Feil
Philippe Arnaud
Imprinted genes play important roles in the regulation of growth and development, and several have been shown to influence behavior. Their allele-specific expression depends on inheritance from either the mother or the father, and is regula...
Cloning and assisted reproductive techniques: influence on early development and adult phenotype [0.03%]
克隆与辅助生殖技术对早期发育及成体表型的影响
Randall R Sakai,Kellie L K Tamashiro,Yukiko Yamazaki et al.
Randall R Sakai et al.
Over the past 40 years, our increased understanding and development of cell and molecular biology has allowed even greater advances in reproductive biology. This is most evident by the development of various aspects of assisted reproductive...
Mechanisms and consequences of paternally-transmitted chromosomal abnormalities [0.03%]
染色体异常的父系遗传机制及影响
Francesco Marchetti,Andrew J Wyrobek
Francesco Marchetti
Paternally-transmitted chromosomal damage has been associated with pregnancy loss, developmental and morphological defects, infant mortality, infertility, and genetic diseases in the offspring, including cancer. There is epidemiological evi...
Wendy Dean,Diana Lucifero,Fátima Santos
Wendy Dean
Epigenetic modification of the cytosine base of DNA by its methylation introduced the possibility that beyond the inherent information contained within the nucleotide sequence there was an additional layer of information added to the underl...
Richard L Gardner
Richard L Gardner
In studies from several laboratories using a variety of different techniques, features of the zygote and two-cell conceptus have been found to map nonrandomly on the blastocyst with respect to both its axis of polarity and bilateral plane. ...
Yasuhide Furuta,Richard R Behringer
Yasuhide Furuta
Annotating the functions of individual genes in in vivo contexts has become the primary task of mouse genetics in the post-genome era. In addition to conventional approaches using transgenic technologies and gene targeting, the recent devel...
Meenakshi Rao,Shanthini Sockanathan
Meenakshi Rao
Research over the past few years has led to dramatic new discoveries on the role of double-stranded RNA (dsRNA) in the cell. RNA duplexes have been shown to orchestrate epigenetic changes, repress translation, and direct mRNA degradation in...
Cell-cell interactions in regulating osteogenesis and osteoblast function [0.03%]
调控成骨和成骨细胞功能的细胞间相互作用
Joseph P Stains,Roberto Civitelli
Joseph P Stains
Endochondral bone formation requires an elaborate interplay among autocrine, paracrine, and endocrine signals, positional cues, and cell-cell contacts to mediate the complex three-dimensional architecture and function of the skeleton. Embry...
Twists and turns in the development and maintenance of the mammalian small intestine epithelium [0.03%]
哺乳动物小肠上皮的发育和维持中的曲折与进展
Andrew L Hauck,Kelly S Swanson,Paul J A Kenis et al.
Andrew L Hauck et al.
Experimental studies during the last decade have revealed a number of signaling pathways that are critical for the development and maintenance of the intestinal epithelium and that demonstrate the molecular basis for a variety of diseases. ...