Robert E Poelmann,Adriana C Gittenberger-de Groot
Robert E Poelmann
Cell death as a phenomenon in embryonic development was first described over 100 years ago. Approximately 30 years ago the process was named apoptosis, and its involvement is now recognized in many life processes, in virtually every animal ...
Patricia Boya,Enrique J de la Rosa
Patricia Boya
Programmed cell death is a relevant process in the physiology and pathology of the nervous system. Neuronal cell death during development is well characterized, and studies of this process have provided valuable information regarding the re...
Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries [0.03%]
滑膜关节和软骨形成机制：最新进展与未解之谜
Maurizio Pacifici,Eiki Koyama,Masahiro Iwamoto
Maurizio Pacifici
Synovial joints are elegant, critically important, and deceptively simple biomechanical structures. They are comprised of articular cartilage that covers each end of the opposing skeletal elements, synovial fluid that lubricates and nourish...
Samuel Tozer,Delphine Duprez
Samuel Tozer
Tendons and ligaments (T/L) are very similar fibrous tissues that respectively connect muscle to bone and bone to bone. They are comprised of fibroblasts that produce large amounts of extra-cellular matrix, resulting in a dense and hypocell...
Véronique Lefebvre,Patrick Smits
Véronique Lefebvre
Chondrogenesis is an essential process in vertebrates. It leads to the formation of cartilage growth plates, which drive body growth and have primary roles in endochondral ossification. It also leads to the formation of permanent cartilagin...
Runx2: a master organizer of gene transcription in developing and maturing osteoblasts [0.03%]
运行蛋白2：一种发育中和成熟的骨细胞基因转录的主调节器
Tania M Schroeder,Eric D Jensen,Jennifer J Westendorf
Tania M Schroeder
Runx2 is essential for osteoblast development and proper bone formation. A member of the Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate transcription of numerous genes and thereby control osteobl...
Maternal nutritional programming of fetal adipose tissue development: long-term consequences for later obesity [0.03%]
母体营养对胎儿脂肪组织发育的表观遗传重编程及后期肥胖的影响
Helen Budge,Mo G Gnanalingham,David S Gardner et al.
Helen Budge et al.
As obesity reaches epidemic levels in the United States there is an urgent need to understand the developmental pathways leading to this condition. Obesity increases the risk of hypertension and diabetes, symptoms of which are being seen wi...
Michael S Huh,Johnathan K Smid,Michael A Rudnicki
Michael S Huh
Skeletal muscles of the trunk and limbs developmentally originate from the cells of the dermomyotomal compartment of the somite. A wealth of knowledge has been accumulated with regard to understanding the molecular regulation of embryonic s...
Georgina Hollway,Peter Currie
Georgina Hollway
The embryonic myotome generates both the axial musculature and the appendicular muscle of the fins and limbs. Early in embryo development the mesoderm is segmented into somites, and within these the primary myotome forms by a complex series...
Maria I Morasso,Nadezda Radoja
Maria I Morasso
Many events in vertebrate morphogenesis and organogenesis develop from epithelial/mesenchymal interactions. These processes involve a series of sequential and reciprocal interactions between the thickened epithelial sheets and underlying me...