(Make) stick and cut loose--disintegrin metalloproteases in development and disease [0.03%]
（黏）住且割断——整合素金属蛋白酶与发育和疾病的关系
Thomas Tousseyn,Ellen Jorissen,Karina Reiss et al.
Thomas Tousseyn et al.
"A disintegrin and metalloprotease" (ADAM) proteases form a still growing family of about 40 type 1 transmembrane proteins. They are defined by a common modular ectodomain architecture that combines cell deadhesion/adhesion and fusion motif...
Kenn Holmbeck,Ludmila Szabova
Kenn Holmbeck
The extracellular matrix is the major constituent of organic matter in both plants and animals, where it provides the interface between individual cells. In most tissues, with some notable exceptions such as bone marrow, the volume of extra...
Vincent Lemaître,Jeanine D&#x;Armiento
Vincent Lemaître
Matrix metalloproteinases (MMPs) are key modulators of many biological processes during pathophysiological events, such as skeletal formation, angiogenesis, cellular migration, inflammation, wound healing, coagulation, lung and cardiovascul...
Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate [0.03%]
从微环境角度探讨干骺端生长板内增生软骨细胞凋亡和存活的命运问题
Irving M Shapiro,Christopher S Adams,Theresa Freeman et al.
Irving M Shapiro et al.
The goal of this review is to examine the fate of the hypertrophic chondrocyte in the epiphyseal growth plate and consider the impact of the cartilage microenvironment on cell survival and apoptosis. Early investigations pointed to a direct...
Regulation of proliferation and apoptosis during development of the preimplantation embryo and the placenta [0.03%]
植入前胚胎和胎盘发育过程中增殖和凋亡的调节
Berthold Huppertz,Andreas Herrler
Berthold Huppertz
The preimplantation embryo starts as a single cell, the zygote. The first cell divisions do not lead to volume expansion, but rather to an increasing number of small cells. At the morula stage the first two cell lineages differentiate into ...
Peter J Hurlin
Peter J Hurlin
N-Myc is a member of the Myc family of proteins, which are best known for their potent oncogenic activities and association with a large proportion of human cancers. Intense scrutiny of the oncogenic properties of Myc family proteins over t...
Proliferation and cornification during development of the mammalian epidermis [0.03%]
哺乳动物表皮发育过程中的增殖和角质化现象
Judith A Mack,Sanjay Anand,Edward V Maytin
Judith A Mack
The skin is the largest organ of the body and consists of the underlying dermis and outer epidermis. Proper embryonic development and continual renewal of the adult epidermis are essential to provide an impenetrable barrier against fluid lo...
Relevance of motoneuron specification and programmed cell death in embryos to therapy of ALS [0.03%]
胚胎运动神经元的确定和程序性细胞死亡与ALS治疗的相关性研究进展
Glen B Banks,Jeffrey S Chamberlain
Glen B Banks
The molecular cues that generate spinal motoneurons in early embryonic development are well defined. Motoneurons are generated in excess and consequently undergo a natural period of programmed cell death. Although it is not known exactly ho...
Molecular mechanisms of trophoblast survival: from implantation to birth [0.03%]
滋养层细胞存活的分子机制：从着床到分娩
Andrea Jurisicova,Jacqui Detmar,Isabella Caniggia
Andrea Jurisicova
Fetal development depends upon a coordinated series of events in both the embryo and in the supporting placenta. The initial event in placentation is appropriate lineage allocation of stem cells followed by the formation of a spheroidal tro...
Teratogen-induced apoptotic cell death: does the apoptotic machinery act as a protector of embryos exposed to teratogens? [0.03%]
致畸物诱导的细胞凋亡死亡：胚胎暴露于致畸物时细胞凋亡机制是否起保护作用？
Arkady Torchinsky,Amos Fein,Vladimir Toder
Arkady Torchinsky
Considerable evidence has been collected demonstrating that many teratogens induce apoptotic cell death in embryonic structures that turn out to be malformed in fetuses and newborns. Apoptosis is a genetically regulated process that is real...