Lin Song,Rocky S Tuan
Lin Song
MicroRNAs (miRNAs) are a group of recently discovered small RNAs produced by the cell using a unique process, involving RNA polymerase II, Microprocessor protein complex, and the RNAase III/Dicer endonuclease complex, and subsequently seque...
Chung-Tien Lee,Tyler Risom,William M Strauss
Chung-Tien Lee
Development in mammals is a complex process requiring gene expression to be spatially and temporally well-regulated. Factors modulate gene functioning by controlling transcription, translation, or mRNA degradation. microRNAs (miRNAs) are a ...
Gianpiero Di Leva,George A Calin,Carlo M Croce
Gianpiero Di Leva
MicroRNAs (miRNAs) are a group of small noncoding RNAs that have been identified in a variety of organisms. These small, 18-22-nucleotide (nt) RNAs are transcribed as parts of longer molecules called pri-miRNAs, which are processed in the n...
Jason R O&#x;Rourke,Maurice S Swanson,Brian D Harfe
Jason R O&#x;Rourke
Mammals have evolved a variety of gene regulatory mechanisms to ensure the proper development of tissues during embryonic organogenesis. Recently, microRNAs (miRNAs) have been shown to regulate protein dosage during mammalian development. m...
Sungroh Yoon,Giovanni De Micheli
Sungroh Yoon
One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) form a class of endogenous 19-23-nucleotide RNAs...
Rick Conrad,Marianne Barrier,Lance P Ford
Rick Conrad
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 17-24 nucleotides (nt) in length that are encoded in the genomes of plants and animals. The seminal discoveries of miRNA made in C. elegans have led the way to the rampant disco...
Michael A Wride,Jenny Geatrell,Jeremy A Guggenheim
Michael A Wride
The eye is one of the classical systems in developmental biology. Furthermore, diseases of the eye, many of which have a developmental basis, have devastating effects that often result in blindness. Proteases have diverse roles in ocular ph...
Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development [0.03%]
肺发育中的并殖平滑肌细胞和肺泡肌成纤维细胞
Namjin Kim,Thiennu H Vu
Namjin Kim
Epithelial-mesenchymal interactions and extracellular matrix remodeling are key processes of embryonic lung development. Lung smooth muscle cells, which are derived from the mesenchyme, form a sheath around bronchi and blood vessels. During...
Matrix metalloproteinases and cellular motility in development and disease [0.03%]
基质金属蛋白酶与细胞运动在发育和疾病中的作用
Michael N VanSaun,Lynn M Matrisian
Michael N VanSaun
The movement of cells and the accompanied remodeling of the extracellular matrix is a critical step in many developmental processes. The matrix metalloproteinases (MMPs) are well recognized as mediators of matrix degradation, and their acti...
Gaoxiang Ge,Daniel S Greenspan
Gaoxiang Ge
The astacin family (M12A) of the metzincin subclan MA(M) of metalloproteinases has been detected in developing and mature individuals of species that range from hydra to humans. Functions of this family of metalloproteinase vary from digest...