B Frank Eames,Luis de la Fuente,Jill A Helms
B Frank Eames
From a traditional viewpoint, skeletal elements form by two distinct processes: endochondral ossification, during which a cartilage template is replaced by bone, and intramembranous ossification, whereby mesenchymal cells differentiate dire...
Noninvasive phenotypic analysis of cardiovascular structure and function in fetal mice using ultrasound [0.03%]
Linda Leatherbury,Qing Yu,Cecilia W Lo
Linda Leatherbury
Methods: We established methods for noninvasive mouse fetal heart imaging using an Acuson/Siemens Sequoia ultrasound scanner equipped with a single-pulse CHIRP Coded Excitation program, and a highfrequency linear array tr...
Christopher J Drake
Christopher J Drake
Two mechanisms account for the formation of blood vessels, vasculogenesis and angiogenesis. Unfortunately, the terms vasculogenesis and angiogenesis literally have the same meaning, i.e., the genesis of blood vessels, and thus do little to ...
Joey V Barnett,Jay S Desgrosellier
Joey V Barnett
The proper formation and function of the vertebrate heart requires a multitude of specific cell and tissue interactions. These interactions drive the early specification and assembly of components of the cardiovascular system that lead to a...
Robert G Gourdie,Brett S Harris,Jaqueline Bond et al.
Robert G Gourdie et al.
The heartbeat is initiated and coordinated by a heterogeneous set of tissues, collectively referred to as the pacemaking and conduction system (PCS). While the structural and physiological properties of these specialized tissues has been st...
Florence Rothenberg,Steven A Fisher,Michiko Watanabe
Florence Rothenberg
The cardiac outflow tract is the site of anomalies that affect a substantial proportion of individuals with congenital heart defects. The morphogenesis of this site is complex, and requires coordinated development of many cell types and tis...
Kenneth Ryan,Alvin J Chin
Kenneth Ryan
Background: T-box genes play roles in vertebrate gastrulation and in later organogenesis. Their existence in all metazoans examined so far indicates that this is an evolutionarily ancient gene family. Drosophila melanogas...
Regulation of heart morphology: current molecular and cellular perspectives on the coordinated emergence of cardiac form and function [0.03%]
Kersti K Linask
Kersti K Linask
Background: During early heart development, in addition to cells being induced to differentiate into cardiomyocytes, pathways are activated that lead to cardiac morphogenesis or the development of form. ...
Mary Redmond Hutson,Margaret L Kirby
Mary Redmond Hutson
Background: Twenty years ago this year was the first publication describing a region of neural crest cells necessary for normal cardiovascular development. Ablation of this region in chick resulted in persistent truncus a...