Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period [0.03%]
着床后早期接触酒精小鼠胚胎全前脑畸形的序列变化
Daisuke Higashiyama,Hirotomo Saitsu,Munekazu Komada et al.
Daisuke Higashiyama et al.
Background: Prenatal exposure to ethanol induces holoprosencephalic malformations in both humans and laboratory animals. However, its teratogenic window for inducing holoprosencephaly is narrow, and the teratogenic mechan...
Application of the automated spatial surveillance program to birth defects surveillance data [0.03%]
自动化空间监测程序在出生缺陷监测数据中的应用
Bennett R Gardner,Matthew J Strickland,Adolfo Correa
Bennett R Gardner
Background: Although many birth defects surveillance programs incorporate georeferenced records into their databases, practical methods for routine spatial surveillance are lacking. We present a macroprogram written for t...
Risk for gastroschisis in primigravidity, length of sexual cohabitation, and change in paternity [0.03%]
初孕、性生活年限和父亲更替与腹裂风险的关系
Monica Rittler,Eduardo E Castilla,Christina Chambers et al.
Monica Rittler et al.
Background: Maternal epidemiologic similarities between gastroschisis and preeclampsia have led to the objective of evaluating the risk for gastroschisis related to primigravidity, change in paternity, and length of cohab...
Christopher B Mayhorn,Richard C Goldsworthy
Christopher B Mayhorn
Background: The current research reports on efforts to refine the design of recently developed teratogen warning symbols and to examine their interpretation by different populations such as those with low health literacy,...
Association of zoonotic Ljungan virus with intrauterine fetal deaths [0.03%]
人畜共患的Ljungan病毒与宫内胎儿死亡的关系
Bo Niklasson,Annika Samsioe,Nikos Papadogiannakis et al.
Bo Niklasson et al.
Background: It has recently been shown that Ljungan virus (LV) is associated with disease in its wild rodent reservoir. In addition, it has been demonstrated that LV causes malformations and perinatal death in a mouse mod...
Randomized Controlled Trial
Birth defects research. Part A, Clinical and molecular teratology. 2007 Jun;79(6):488-93. DOI:10.1002/bdra.20359 2007
Health care expenditures of children and adults with spina bifida in a privately insured U.S. population [0.03%]
美国脊柱裂患儿和成人参保人群的医疗保健支出
Lijing Ouyang,Scott D Grosse,Brian S Armour et al.
Lijing Ouyang et al.
Background: We provide new estimates of medical care utilization and expenditures over the lifespan for persons living with spina bifida in the United States. Updated estimates are essential for calculations of lifetime c...
Aortic and ventricular dilation and myocardial reduction in gestation day 17 ICR mouse fetuses of diabetic mothers [0.03%]
糖尿病母亲的ICR胎鼠主动脉和心室扩张以及心肌减少（妊娠第17天）
J Claudio Gutierrez,Terry C Hrubec,M Renee Prater et al.
J Claudio Gutierrez et al.
Background: Maternal diabetes mellitus is associated with increased fetal teratogenesis, including cardiovascular defects. Information regarding cardiovascular changes in late-gestation fetal mice, related to maternal hyp...
Altered localization of gene expression in both ectoderm and mesoderm is associated with a murine strain difference in retinoic acid-induced forelimb ectrodactyly [0.03%]
与视黄酸诱导的前肢手指畸形的小鼠品系差异有关的外胚层和中胚层基因表达定位的改变
Hirohito Shimizu,Grace S Lee,Sudheer R Beedanagari et al.
Hirohito Shimizu et al.
Background: Defects in digit number or fusion as a teratogenic response are well documented in humans and intensively studied in various mouse models. Maternal exposure to excess levels of all-trans-retinoic acid (RA) at ...
Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines [0.03%]
菲律宾孕妇血浆磷酸吡哆醛浓度与孤立性唇腭裂风险的关系
Tsunenobu Tamura,Ronald G Munger,Buena Nepomuceno et al.
Tsunenobu Tamura et al.
Background: We report that inadequate vitamin B-6 status of Filipino mothers, assessed by erythrocyte aspartate aminotransferase activity coefficient (EAST-AC), is associated with an increased risk for isolated cleft lip ...
Robert L Brent
Robert L Brent