Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity [0.03%]
人类胚胎多药治疗与hERG阻滞抗癫痫药引起的胎儿心律失常和致畸风险增加有关
Christian Danielsson,Faranak Azarbayjani,Anna-Carin Sköld et al.
Christian Danielsson et al.
Background: The antiepileptic drugs (AEDs) phenytoin, phenobarbital, dimethadione, and carbamazepine cause a similar pattern of malformations in humans, with an increased risk after polytherapy. The teratogenicity has bee...
Füsun Alehan,Ilknur Erol,Ozge Sürmeli Onay
Füsun Alehan
Background: Carbon monoxide (CO) poisoning in pregnancy is a relatively rare occurrence, but it can result in fetal mortality and neurologic complications in fetuses who survive to term. ...
Kênia B El-Jaick,Renata F Fonseca,Miguel A Moreira et al.
Kênia B El-Jaick et al.
Background: Single median maxillary central incisor (SMMCI) is a rare anomaly that may occur alone or associated with other conditions, frequently as part of the holoprosencephaly (HPE) spectrum. However, it has been sugg...
Niels Beurskens,Merel Klaassens,Robbert Rottier et al.
Niels Beurskens et al.
Background: Congenital diaphragmatic hernia (CDH) is a major life-threatening malformation, occurring in approximately 1 in 3,000 live births. Over the years, different animal models have been used to gain insight into th...
Duodenal atresia in an infant with triple-X syndrome: a new associated malformation in 47,XXX [0.03%]
三体综合征中肠/atresia患儿1例报告
Udo Rolle,Barbara Linse,Simone Glasow et al.
Udo Rolle et al.
Background: An association between the triple-X syndrome (47,XXX) and gastrointestinal malformations is extremely rare. Most 47,XXX patients present with a normal phenotype, but genitourinary malformations have been descr...
High fever-related maternal diseases as possible causes of multiple congenital abnormalities: a population-based case-control study [0.03%]
高热相关母体疾病可能是多种先天畸形的致病因素：一项基于人群的病例对照研究
Andrew E Czeizel,Erzsébet H Puhó,Nándor Acs et al.
Andrew E Czeizel et al.
Background: Multiple congenital abnormalities (MCAs) represent the most severe category of structural birth defects; therefore, we decided to evaluate the possible etiological factors for MCAs. ...
Role of annexin 1 gene expression in mouse craniofacial bone development [0.03%]
Annexin A1基因在小鼠颅面骨发育中的作用研究
Amilcar Sabino Damazo,Niloufar Moradi-Bidhendi,Sonia Maria Oliani et al.
Amilcar Sabino Damazo et al.
Background: Annexin 1 is a 37-kDa protein that has complex intra- and extracellular effects. To discover whether the absence of this protein alters bone development, we monitored this event in the annexin-A1 null mice in ...
Marilyn L Browne,Erin M Bell,Charlotte M Druschel et al.
Marilyn L Browne et al.
Background: The physiologic effects and common use of caffeine during pregnancy call for examination of maternal caffeine consumption and risk of birth defects. Epidemiologic studies have yielded mixed results, but such s...
Randomized Controlled Trial
Birth defects research. Part A, Clinical and molecular teratology. 2007 Jul;79(7):533-43. DOI:10.1002/bdra.20365 2007
Poland syndrome associated with an aberrant subclavian artery and vascular abnormalities of the retina in a child exposed to misoprostol during pregnancy [0.03%]
妊娠期使用米索前列醇致胎儿 Poland 综合征、迷走型主动脉弓和视网膜血管异常的病例报告
Rafael Fabiano Machado Rosa,Giovanni M Travi,Fabiana Valiatti et al.
Rafael Fabiano Machado Rosa et al.
Background: Poland syndrome has been attributed to a process of vascular disruption, and exposure to misoprostol at 6-8 weeks of gestation has been shown to produce defects attributed to vascular disruption. Herein we rep...