Perturbation of retinoic acid (RA)-mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanol [0.03%]
视黄酸（RA）介导的肢发育干扰提示其在酒精致畸中的作用可能是因为减少了RA信号转导
Corey S Johnson,Robert M Zucker,Edward Sidney Hunter rd et al.
Corey S Johnson et al.
Background: A proposed mechanism for ethanol teratogenicity entails ethanol-mediated reductions in retinoic acid (RA). This premise was investigated utilizing a mouse model, with limb reduction defects as the teratogenic ...
Role of nitric oxide in chick embryonic organogenesis and dysmorphogenesis [0.03%]
一氧化氮在鸡胚器官发生及畸形发生中的作用研究进展
Peter G Alexander,Lillian Chau,Rocky S Tuan
Peter G Alexander
Background: Nitric oxide (NO), produced by the nitric oxide synthase family of enzymes, mediates multiple signaling functions, and when unchecked, NO causes pathological damage. Exposure of embryos to a variety of teratog...
Lavinia Schuler-Faccini,Rosa Castalia Franca Soares,Artur Custodio Moreira de Sousa et al.
Lavinia Schuler-Faccini et al.
Thalidomide is the best known human teratogen. Although withdrawn from the market in 1961, thalidomide was remarketed after 1965 in several countries, for the treatment of erythema nodosum leprosum. Thalidomide has a potent immunomodulatory...
Selection of controls in case-control studies on maternal medication use and risk of birth defects [0.03%]
病例对照研究中母亲用药与出生缺陷关联的研究对象选择
Marian K Bakker,Hermien E K de Walle,Aileen Dequito et al.
Marian K Bakker et al.
Background: In case-control studies on teratogenic risks of maternal drug use during pregnancy, the use of normal or malformed controls may lead to recall-bias or selection bias. This can be avoided by using controls with...
Australian survey on community knowledge and attitudes regarding the fortification of food with folic acid [0.03%]
关于食品中叶酸强化的社区知识和态度的澳大利亚调查研究
Caron Molster,Carol Bower,Peter O&#x;Leary
Caron Molster
Background: In response to the proposal that mandatory fortification be introduced in Australia to reduce the incidence of NTDs, the purpose of this study was to establish, for the adult community, baseline data on knowle...
Teratology public affairs committee position paper: Pregnancy labeling for prescription drugs: Ten years later [0.03%]
胎胚学公共事务委员会立场文件：十年之后的处方药妊娠分级体系
Public Affairs Committee of the Teratology Society
Public Affairs Committee of the Teratology Society
Evyn J Loucks,Tyler Schwend,Sara C Ahlgren
Evyn J Loucks
Background: Exposure of zebrafish embryos to a number of teratogens results in cyclopia, but little is known about the underlying molecular changes. Metho...
Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage [0.03%]
硝基苯甲醇自由基能保护糖尿病引起的胎鼠和卵黄囊的损伤
Seonghun Ryu,Roni Kohen,Amram Samuni et al.
Seonghun Ryu et al.
Background: Diabetic teratogenicity relates, partly, to embryonic oxidative stress and the extent of the embryonic damage can apparently be reduced by antioxidants. We investigated the effects of superoxide dismutase-mimi...
Neural tube defects, micronutrient deficiencies, and Helicobacter pylori: a new hypothesis [0.03%]
神经管缺陷、微量元素缺乏和幽门螺杆菌：一种新假说
Marilyn Felkner,Lucina Suarez,Beata Liszka et al.
Marilyn Felkner et al.
Background: Previous findings for the Texas Neural Tube Defects Project suggested that while maternal access to nutrients is adequate, bioavailability of nutrients to the fetus is compromised in NTD-affected pregnancies. ...
A1298C polymorphism of the MTHFR gene and neural tube defects in the state of Yucatan, Mexico [0.03%]
墨西哥尤卡坦州5,10亚甲基四氢叶酸还原酶基因A1298C多态性与神经管缺陷关系的研究
Lizbeth Gonzalez-Herrera,Ileana Castillo-Zapata,Guadalupe Garcia-Escalante et al.
Lizbeth Gonzalez-Herrera et al.
Background: Methylenetetrahydrofolate reductase (MTHFR) of the folate metabolism pathway is a candidate gene for neural tube defects (NTDs). Frequency of the second common polymorphism, A1298C, in the MTHFR gene is not we...