Two-phase designs for cost-effective evaluation of cancer screening tests [0.03%]
成本效益癌症筛查试验的两阶段设计评估研究
Fangya Mao,Richard J Cook,Thomas Lorey et al.
Fangya Mao et al.
Screening tests are crucial for detecting diseases at preclinical stages when timely intervention can prevent progression to more severe conditions. Advances in technology have facilitated developing screening tests based on novel markers, ...
A zero-inflated hierarchical generalized transformation model to address non-normality in spatially-informed cell-type deconvolution [0.03%]
一种零膨胀分层广义变换模型，用于解决空间信息细胞去卷积中的非正态性问题
Hunter J Melton,Jonathan R Bradley,Chong Wu
Hunter J Melton
Oral squamous cell carcinomas (OSCC), the predominant head and neck cancer, pose significant challenges due to late-stage diagnoses and low five-year survival rates. Spatial transcriptomics offers a promising avenue to decipher the genetic ...
Bayesian shrinkage priors for penalized synthetic control estimators in the presence of spillovers [0.03%]
存在溢出效应时贝叶斯收缩先验下的惩罚合成控制估计量
Esteban Fernández-Morales,Arman Oganisian,Youjin Lee
Esteban Fernández-Morales
Synthetic control (SC) methods are widely used to estimate the effects of policy interventions, especially those targeting specific geographic regions, referred to as units. These methods construct a weighted combination of untreated units,...
Measurement error-robust causal inference via constructed instrumental variables [0.03%]
基于构造工具变量的稳健因果推断方法研究
Caleb H Miles,Linda Valeri,Brent Coull
Caleb H Miles
Measurement error can often be harmful when estimating causal effects. Two scenarios in which this is the case are in the estimation of (a) the average treatment effect when confounders are measured with error, and (b) the natural indirect ...
Zhixian Yang,Peijun Sang,Yixin Han et al.
Zhixian Yang et al.
One of the primary goals of individualized treatment rule (ITR) methodology is to identify optimal decision rules using clinical predictors. While functional data has become increasingly available in biomedical research, there has been limi...
Simultaneous clustering and estimation of additive shape invariant models for recurrent event data [0.03%]
加性形状不变模型的递归事件数据的聚类和估计
Zitong Zhang,Shizhe Chen
Zitong Zhang
Technological advancements have enabled the recording of spiking activities from large neuron ensembles, presenting an exciting yet challenging opportunity for statistical analysis. This project considers the challenges from a common type o...
Rank-adaptive covariance testing with applications to genomics and neuroimaging [0.03%]
基于秩自适应的协方差检验及其在基因组学和脑影像学中的应用
David Veitch,Yinqiu He,Jun Young Park
David Veitch
In biomedical studies, testing for differences in covariance may offer scientific insights, especially when differences are driven by complex joint behavior between features. However, when differences in joint behavior are weakly dispersed ...
Making all pairwise comparisons in multi-arm clinical trials without control treatment [0.03%]
无对照治疗的多臂临床试验中的所有两两比较方法研究
T Burnett,T Jaki
T Burnett
The standard paradigm for confirmatory clinical trials is to compare experimental treatments with a control, for example, the standard of care or a placebo. However, it is not always the case that a suitable control exists. Efficient statis...
Comparative Study
Biometrics. 2026 Jan 6;82(1):ujag048. DOI:10.1093/biomtc/ujag048 2026
LLOT: application of Laplacian Linear Optimal Transport in spatial transcriptome reconstruction [0.03%]
基于拉普拉斯线性最优传输的空間轉錄組重建方法
Junhao Zhu,Kevin Zhang,Dehan Kong et al.
Junhao Zhu et al.
Single-cell RNA sequencing (scRNA-seq) allows transcriptional profiling, and cell-type annotation of individual cells. However, sample preparation in typical scRNA-seq experiments often homogenizes the samples, thus spatial locations of ind...