Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data [0.03%]
基于真实世界数据模拟目标试验评估妊娠早期使用二甲双胍与自然流产和先天畸形风险的关系
Yu-Han Chiu,Krista F Huybrechts,Elisabetta Patorno et al.
Yu-Han Chiu et al.
Background: Metformin is a first-line pharmacotherapy for type 2 diabetes, but there is limited evidence about its safety in early pregnancy. Objective: ...
Observational Study
Annals of internal medicine. 2024 Jul;177(7):862-870. DOI:10.7326/M23-2038 2024
Michael R Privitera,Tait D Shanafelt
Michael R Privitera
Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns [0.03%]
孕前父亲精子发育期使用二甲双胍与新生儿重大先天畸形风险的关系
Ran S Rotem,Marc G Weisskopf,Krista F Huybrechts et al.
Ran S Rotem et al.
Background: Metformin is the most used oral antidiabetic medication. Despite its established safety profile, it has known antiandrogenic and epigenetic modifying effects. This raised concerns about possible adverse develo...
COVID-19 Vaccine Side Effects and Long-Term Neutralizing Antibody Response : A Prospective Cohort Study [0.03%]
关于新型冠状病毒肺炎疫苗的副作用及长期血清学反应：前瞻性队列研究
Ethan G Dutcher,Elissa S Epel,Ashley E Mason et al.
Ethan G Dutcher et al.
Background: Concern about side effects is a common reason for SARS-CoV-2 vaccine hesitancy. Objective: To determine whether short-term ...
Type 2 Diabetes [0.03%]
2型糖尿病
Allison L Crawford,Neda Laiteerapong
Allison L Crawford
Type 2 diabetes (T2D) is a prevalent disease that increases risk for vascular, renal, and neurologic complications. Prevention and treatment of T2D and its complications are paramount. Many advancements in T2D care have emerged over the pas...
Feeling the Heat: Cardiovascular Consequences of Heat Exposure Under Controlled Experimental Conditions [0.03%]
实验环境下高温暴露导致心血管不适的机制研究
Eliseo Guallar,Paco E Bravo,Victor A Ferrari
Eliseo Guallar
The Effect of Heat Exposure on Myocardial Blood Flow and Cardiovascular Function [0.03%]
热暴露对心肌血流和心血管功能的影响
Hadiatou Barry,Josep Iglesies-Grau,Georgia K Chaseling et al.
Hadiatou Barry et al.
Background: Heat extremes are associated with greater risk for cardiovascular death. The pathophysiologic mechanisms mediating this association are unknown. ...
Clinical Trial
Annals of internal medicine. 2024 Jul;177(7):901-910. DOI:10.7326/M24-3504 2024
How Would You Manage This Patient With Type 2 Diabetes and Chronic Kidney Disease? Grand Rounds Discussion From Beth Israel Deaconess Medical Center [0.03%]
2型糖尿病伴慢性肾病患者的诊疗方案讨论——来自贝斯以色列女执事医疗中心的教学查房
Gerald W Smetana,Giulio R Romeo,Sylvia E Rosas et al.
Gerald W Smetana et al.
Nearly 15% of U.S. adults have diabetes; type 2 diabetes (T2D) accounts for more than 90% of cases. Approximately one third of all patients with diabetes will develop chronic kidney disease (CKD). All patients with T2D should be screened an...