Propensity score applied to survival data analysis through proportional hazards models: a Monte Carlo study [0.03%]
倾向值在生存数据分析中通过比例风险模型的应用：一个蒙特卡罗研究
Etienne Gayat,Matthieu Resche-Rigon,Jean-Yves Mary et al.
Etienne Gayat et al.
Propensity score methods are increasingly used in medical literature to estimate treatment effect using data from observational studies. Despite many papers on propensity score analysis, few have focused on the analysis of survival data. Ev...
Kimberly S Crimin,Joseph W McKean,Thomas J Vidmar
Kimberly S Crimin
During drug development, the calculation of inhibitory concentration that results in a response of 50% (IC50) is performed thousands of times every day. The nonlinear model most often used to perform this calculation is a four-parameter log...
A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies [0.03%]
非线性混合效应模型确定取样窗口的通用方法及其在人群药代动力学研究中的应用
Lee Kien Foo,James McGree,Stephen Duffull
Lee Kien Foo
Optimal design methods have been proposed to determine the best sampling times when sparse blood sampling is required in clinical pharmacokinetic studies. However, the optimal blood sampling time points may not be feasible in clinical pract...
Prediction of accrual closure date in multi-center clinical trials with discrete-time Poisson process models [0.03%]
基于离散时间泊松过程模型的多中心临床试验结算截止日期预测
Gong Tang,Yuan Kong,Chung-Chou Ho Chang et al.
Gong Tang et al.
In a phase III multi-center cancer clinical trial or a large public health study, sample size is predetermined to achieve desired power, and study participants are enrolled from tens or hundreds of participating institutions. As the accrual...
Michael J Sweeting,Adrian P Mander
Michael J Sweeting
Phase I clinical trials aim to identify a maximum tolerated dose (MTD), the highest possible dose that does not cause an unacceptable amount of toxicity in the patients. In trials of combination therapies, however, many different dose combi...
Guogen Shan,Alan D Hutson,Gregory E Wilding
Guogen Shan
In preclinical studies and clinical dose-ranging trials, the Jonckheere-Terpstra test is widely used in the assessment of dose-response relationships. Hewett and Spurrier (1979) presented a two-stage analog of the test in the context of lar...
Xu Steven Xu,Min Yuan,Partha Nandy
Xu Steven Xu
Assessing dose-response from flexible-dose clinical trials (e.g., titration or dose escalation studies) is challenging and often problematic due to the selection bias caused by 'titration-to-response'. We investigate the performance of a dy...
Expected loss functions as additional measures to assess performance of multiple testing procedures for combination drug dose finding [0.03%]
期望损失函数作为组合药物剂量寻找多重检验方法的性能评估标准措施
Julia N Soulakova,Allan R Sampson
Julia N Soulakova
There are several measures that are commonly used to assess performance of a multiple testing procedure (MTP). These measures include power, overall error rate (family-wise error rate), and lack of power. In settings where the MTP is used t...
Sample sizes for trials involving multiple correlated must-win comparisons [0.03%]
涉及多个相关必须获胜的比较试验的样本量
Steven A Julious,Nikki E McIntyre
Steven A Julious
In Clinical trials involving multiple comparisons of interest, the importance of controlling the trial Type I error is well-understood and well-documented. Moreover, when these comparisons are themselves correlated, methodologies exist for ...
A Bayesian approach to the statistical analysis of device preference studies [0.03%]
贝叶斯方法在医疗器械偏好研究中的应用与评价
Haoda Fu,Yongming Qu,Baojin Zhu et al.
Haoda Fu et al.
Drug delivery devices are required to have excellent technical specifications to deliver drugs accurately, and in addition, the devices should provide a satisfactory experience to patients because this can have a direct effect on drug compl...