Targeting NDUFS4 Disrupts Oxidative Phosphorylation and Induces Ferroptosis in Olaparib-Resistant Prostate Cancer [0.03%]
靶向NDUFS4干扰氧化磷酸化并诱导奥拉帕尼耐药性前列腺癌的铁死亡
Zachary A Schaaf,Shu Ning,Amy R Leslie et al.
Zachary A Schaaf et al.
Resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) remains a major challenge in the treatment of advanced prostate cancer. Although metabolic rewiring has been implicated in this process, the molecular drivers and therapeutic vuln...
GITR and GITR-L RNA Expression Levels Correlate with Better Survival and Response to Immunotherapy [0.03%]
GITR和GITRL的RNA表达水平与更好的生存率和对免疫疗法的反应有关
Peter Moussa,Razelle Kurzrock,Daisuke Nishizaki et al.
Peter Moussa et al.
Glucocorticoid-induced tumor necrosis factor-related protein (GITR) is an immune stimulator; however, the correlation between GITR and GITR ligand (GITR-L) expression levels and patient outcomes is not yet characterized. This study explores...
Retraction: Enhancing Chemosensitivity of Breast Cancer Stem Cells by Downregulating SOX2 and ABCG2 Using Wedelolactone-Encapsulated Nanoparticles [0.03%]
撤稿：利用番木鳖碱包封的纳米颗粒下调SOX2和ABCG2以增强乳腺癌干细胞的化学敏感性
Sreemanti Das,Pritha Mukherjee,Ranodeep Chatterjee et al.
Sreemanti Das et al.
HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc-driven small cell lung cancer [0.03%]
组蛋白脱乙酰酶抑制剂通过诱导MYC驱动的小细胞肺癌的肿瘤可塑性增强免疫治疗疗效
Azam Ghafoor,Linying Zhu,Zoe Weaver Ohler et al.
Azam Ghafoor et al.
Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy, accounting for approximately 15% of all lung cancer cases. Characterized by low immunogenicity, SCLC may utilize epigenetic mechanisms to evade immune detection. Here, we demo...
Synthetic inducible bacteria normalize the microenvironment of refractory tumors, potentiating checkpoint inhibitor responses [0.03%]
合成感应细菌可调节难治性肿瘤的微环境，增强检查点抑制剂的治疗效果
Myrofora Panagi,Fotios Mpekris,Marcos Burger Ramos et al.
Myrofora Panagi et al.
Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironment (TME). A dense/stiff extracellular matrix (ECM) can hinder immune cell infiltration, li...
YB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression [0.03%]
YB-1抑制可抑制骨肉瘤生长并逆转肿瘤免疫抑制作用
Sanjay V Malhotra,Kirsten Stefan,Jee Min Lee et al.
Sanjay V Malhotra et al.
Osteosarcoma (OS), the most common primary bone malignancy in adolescents and young adults, is still marked by poor long-term survival and poor mortality. Although immune checkpoint blockade (ICB) has transformed treatment for several cance...
Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young [0.03%]
全面的多平台酪氨酸激酶谱分析揭示了横贯影响年轻人肉瘤的新型可操作FGFR异常
Ashleigh M Fordham,Lauren M Brown,Chelsea Mayoh et al.
Ashleigh M Fordham et al.
Limited targeted agents are approved for pediatric sarcomas. Tyrosine kinase (TK) inhibitors (TKi) have shown clinical efficacy in some, but not all, young patients with sarcoma. A major obstacle preventing further advances and clinical imp...
Targeting Semaphorin 7a Signaling in Preclinical Models of Endocrine Therapy-Resistant Breast Cancer [0.03%]
靶向分泌素7a信号抵抗内分泌治疗的小鼠模型乳腺癌研究
Rachel N Steinmetz,Veronica Wessells,Heather Fairchild et al.
Rachel N Steinmetz et al.
Estrogen receptor-positive (ER+) breast cancers comprise more than 70% of breast cancers and are the leading cause of breast cancer-related deaths in women worldwide. Despite available therapies that target ER, recurrence occurs in many pat...
Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells [0.03%]
组蛋白去甲基酶抑制剂GSK-J4诱导卵巢癌细胞中不同的H3K27甲基化状态及其生物学功能响应
Marcos Quintela,Lydia C Powell,Agne Baseviciene et al.
Marcos Quintela et al.
The deregulation of histone methylation has been implicated in the pathogenesis of multiple diseases, including ovarian cancer, one of the most lethal gynecologic malignancies worldwide. The roles of the lysine 27 on histone 3 (H3K27) demet...
MRTX1133 Suppresses ERK Signaling but Elicits Context-Dependent Antiproliferative Responses in KRAS (G12C) Cancer Cells [0.03%]
MRTX1133 抑制 ERK 信号传导，但在 KRAS(G12C) 癌细胞中产生上下文依赖性的抗增殖反应
Abraham C Sianoya,Yan Zuo,Cynthia V Pagba et al.
Abraham C Sianoya et al.
KRAS is a high-value therapeutic target for the treatment of cancer. Two covalent inhibitors, sotorasib and adagrasib, which target a specific codon 12 mutation (G12C), had received accelerated approvals for clinical use. Studies of these i...