Conformational variants of the ternary complex of C5a, C5aR1, and G-protein [0.03%]
C5a、C5aR1和G蛋白的三元复合物的构象变体
Pulkit Kr Gupta,Aditi Singh,Soumendra Rana
Pulkit Kr Gupta
The complement component fragment 5a (C5a) binds and activates two complement receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the proinflammatory function of C5a in tissues through the recruitment of heterotri...
Correction [0.03%]
纠正
Novel integrated Omics based computational approach for drug repurposing for non-muscle invasive bladder cancer (NMIBC) [0.03%]
基于计算的新型整合组学非肌肉侵袭性膀胱癌(NMIBC)药物新用途研究方法
Tiantian Liu,Waqar- Ul-Haq,Qing Tang et al.
Tiantian Liu et al.
Non-muscle invasive bladder cancer (NMIBC) refers to a subtype of bladder carcinoma where cancer is localized in the inner lining of bladder. NMIBC consider as one of most costly malignancy and requires significant surgical and therapeutic ...
Identification of novel inhibitor phytoconstituents for Influenza A H3N2: an in silico approach [0.03%]
新型抑制植物成分在流感A H3N2中的鉴定：一种基于计算机的方案
Rajan Rolta,Deeksha Salaria,Olatomide A Fadare et al.
Rajan Rolta et al.
Influenza A virus subtype H3N2 is a highly infectious respiratory virus that is responsible for global seasonal flu epidemics. The current study was designed to investigate the antiviral activity of 150 phytocompounds of North Western Himal...
Development of venetoclax with 2-hydroxypropyl-beta-cyclodextrin inclusion complex for improved bioavailability [0.03%]
2-羟基丙基-β-环糊精包合物在提高维奈托克生物利用度中的发展应用研究
Smalant Kishor Patil,Padakanti Sandeep Chary,Sarvan Maddipatla et al.
Smalant Kishor Patil et al.
Cyclodextrin complexes loaded with venetoclax for improved solubility and therapeutic efficacy as repurposed drug. The venetoclax-cyclodextrin inclusion complex was prepared using kneading method. Primarily in-silico molecular docking study...
Tanreqing suppresses the proliferation and migration of non-small cell lung cancer cells by mediating the inactivation of the HIF1α signaling pathway via exosomal circ-WDR78 [0.03%]
通过外泌体circ-WDR78介导HIF1α信号通路的失活，Tanreqing抑制非小细胞肺癌细胞的增殖和迁移
Weijun Hong,Kaifeng Du,Qingqing Zhang et al.
Weijun Hong et al.
Circular RNAs (circRNAs) have emerged as regulators of cancer progression, including non-small cell lung cancer (NSCLC). Tanreqing (TRQ), a traditional Chinese medicine, is used clinically for respiratory diseases. RT-qPCR quantified circ-W...
In-silico investigation of RPS6KB1 associated cancer inhibitor: a drug repurposing study [0.03%]
RPS6KB1相关的癌症抑制剂的虚拟调查：一种药物新用途的研究
Saravanan Rajendrasozhan,Irfan Ahmad,Safia Obaidur Rab et al.
Saravanan Rajendrasozhan et al.
The ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70S6 kinase, plays a crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its activity is regulated by phosphorylation events, including p...
Identification of ZINC08101049 as a potential IL1β inhibitor through molecular docking and MD simulations for cancer therapeutics [0.03%]
通过分子对接和MD模拟识别ZINC08101049作为潜在的IL1β抑制剂用于癌症治疗
Mohammad Y Alshahrani,Muath Suliman,Mohammad Ali Abdullah Almoyad et al.
Mohammad Y Alshahrani et al.
Cancer is a significant global health concern that has a major impact on morbidity and mortality worldwide. Research has demonstrated the involvement of Interleukin-1 beta (IL1β) in various aspects of cancer development and progression, in...
Elucidating anti-sclerostin mechanism of baicalein using LRP6-Sclersotin complex of canonical Wnt/β-catenin signaling pathway [0.03%]
利用经典的Wnt/β-连环蛋白信号通路的LRP6-硬化性复合物阐释黄芩素抗硬化性机制
Rajeshwari Muniyasamy,I Manjubala
Rajeshwari Muniyasamy
Flavonoids are polyphenolic compounds produced by plants as secondary metabolites that are known to exhibit wide range of pharmaceutical properties. Flavonoids from different medicinal plants have been used in traditional medicine to treat ...
Insightful t-SNE guided exploration spotlighting Palbociclib and Ribociclib analogues as novel WEE1 kinase inhibitory candidates [0.03%]
洞察力的t-SNE引导探索，突出Palbociclib和Ribociclib类似物作为新型WEE1激酶抑制剂候选药物的可能性
Rajesh Muthuraj,Dhanushya Gopal,Iqrar Ahmed et al.
Rajesh Muthuraj et al.
In the era of targeted therapeutics, protein kinases like WEE1 have become pivotal drug targets, especially for cancer therapy. Utilizing a multi-faceted approach, our study adds fresh insights to this endeavour. We employed the t-SNE algor...