Identification of potential regulatory mechanisms and therapeutic targets for lung cancer [0.03%]
肺癌潜在调控机制和治疗靶点的识别
Anjali Priya,Mohammed Dashti,Thangavel Alphonse Thanaraj et al.
Anjali Priya et al.
Lung cancer poses a significant health threat globally, especially in regions like India, with 5-year survival rates remain alarmingly low. Our study aimed to uncover key markers for effective treatment and early detection. We identified sp...
In silico and structural investigation of sulfonamides targeting VraSR two component system in methicillin-resistant Staphylococcus aureus [0.03%]
针对耐甲氧西林金黄色葡萄球菌中VraSR双组分系统的磺胺类药物的计算和结构研究
Abhishek Kumar Verma,Sandeep Kumar Srivastava
Abhishek Kumar Verma
Drug-resistant Staphylococcus aureus strains are global health concerns. Several studies have shown that these strains can develop defences against cell wall antibiotics such as β-lactams, glycopeptides and daptomycin which target cell wal...
Identification of selective plant-derived natural carotenoid and flavonoids as the potential inhibitors of DHHC-mediated protein S- palmitoylation: an in silico study [0.03%]
选择性植物来源的天然类胡萝卜素和黄酮作为DHHC介导的蛋白质S-棕榈酰化的潜在抑制剂的识别：一种计算机模拟研究
Suchi Chaturvedi,Nirali Pandya,Sushabhan Sadhukhan et al.
Suchi Chaturvedi et al.
Protein S-palmitoylation mediated by DHHCs is recognized as a distinct and reversible form of lipid modification connected with several health perturbations, including neurodegenerative disorders, cancer, and autoimmune conditions. However,...
In-vitro antimicrobial activity of AF-DP protein and in-silico approach of cell membrane disruption [0.03%]
AF-DP蛋白的体外抗菌活性及细胞膜破坏的计算机模拟方法
Fatemeh Velayatipour,Hossein Tarrahimofrad,Javad Zamani et al.
Fatemeh Velayatipour et al.
Microbial resistance against common antibiotics has become one of the most serious threats to human health. The increasing statistics on this problem show the necessity of finding a way to deal with it. In recent years, antimicrobial peptid...
Insight into the interaction of isochroman with bovine serum albumin: extensive experimental and computational investigations [0.03%]
异色满与牛血清白蛋白相互作用的见解：广泛的实验和计算研究
Sana Fatima,Irfan Hussain,Shahbaz Ahmed et al.
Sana Fatima et al.
The way therapeutic compounds interact with serum protein provides valuable information on their pharmacokinetics, toxicity, effectiveness, and even their structural-related information. Isochroman (IC) is a phytochemical compound obtained ...
Decoding the structural integrity and multifunctional role of Era protein in the survival of Mycobacterium tuberculosis H37Rv [0.03%]
结核分枝杆菌H37Rv中Era蛋白的结构完整性和多功能作用及其在生存中的解码研究
Preeti Agarwal,Ajit Kumar,Laxman S Meena
Preeti Agarwal
Era, a widely known GTP binding protein found in many organisms including prokaryotes and eukaryotes and plays a significant role in many fundamental cellular processes like cell growth, differentiation and signaling. In Mycobacterium tuber...
Sonia Kaushik,Rashmi Rameshwari,Shilpa S Chapadgaonkar
Sonia Kaushik
Functioning as a flavoprotein, choline oxidase facilitates the transformation of choline into glycine betaine. Notably, choline oxidase and its resultant product, glycine betaine, find extensive applications across various industries and fi...
Design of human ACE2 mimic miniprotein binders that interact with RBD of SARS-CoV-2 variants of concerns [0.03%]
设计模仿人类ACE2的迷你蛋白质结合体与SARS-CoV-2关切变异株RBD相互作用
Neeraj K Gaur,Zeenat Khakerwala,Ravindra D Makde
Neeraj K Gaur
The world of medicine demands from the research community solutions to the emerging problem of SARS-CoV-2 variants and other such potential global pandemics. With advantages of specificity over small molecule drugs and designability over an...
Aromatase inhibitors identified from Saraca asoca to treat infertility in women with polycystic ovary syndrome via in silico and in vivo studies [0.03%]
通过计算机模拟和体内研究从Saraca asoca鉴定出的用于治疗多囊卵巢综合征女性不孕症的芳香化酶抑制剂
Kuppachi Himaja,Kandasamy Veerapandiyan,Balasundaram Usha
Kuppachi Himaja
Polycystic ovary syndrome (PCOS) is a widely occurring metabolic disorder causing infertility in 70%-80% of the affected women. Saraca asoca, an ancient medicinal herb, has been shown to have therapeutic effects against infertility and horm...
Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations [0.03%]
基于噻唑烷二酮的胰脂肪酶抑制剂作为抗肥胖药物的研究：合成，计算机模拟研究和药理学研究
Prashant Dhiman,Nisha Yadav,Prashant S Auti et al.
Prashant Dhiman et al.
A series of new 2,5-disubstituted arylidene derivatives of thiazolidinedione (16a-e, 17a-d, 18a-c) designed using molecular hybridization approach were synthesized, structurally characterized, and explored for their anti-obesity potential v...